| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| SN 50 induced apoptosis in MM cell lines and patient cells ; down regulated expression of Bcl 2 , A 1 , 10 chromosome linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein 1 ( cIAP 1 ) , cIAP 2 , and survivin ; up regulated Bax ; increased mitochondrial cytochrome c release into the cytoplasm ; and activated caspase 9 and caspase 3 , but not caspase 8 . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ( 1 ) Inhibition of NF kappaB activation results in apoptosis . ( 2 ) Inhibitor of apoptosis protein ( IAP ) family members , inhibitor of apoptosis protein 1 ( cIAP 1 ) , and 10 chromosome linked IAP , are expressed in rat hepatocytes . cIAP 2 is induced by cytokines in an NF kappaB dependent manner and overexpression of cIAP 2 inhibits apoptosis . ( 3 ) The anti apoptotic Bcl 2 family member A1 / Bfl 1 and the pro apoptotic members Bak and Bid are induced by cytokines and NF kappaB dependent . ( 4 ) Nitric oxide inhibits caspase 3 activity in hepatocytes . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| The treatment with DNP also markedly reduced levels of Bcl 2 , inhibitor of apoptosis protein 1 , and inhibitor of apoptosis protein 2 and increased the level of Bax and cytochrome c release into cytoplasm and subsequent caspase 3 activation , which co occurred with increased apoptosis . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : To investigate the expression of API 2 MALT1 fusion gene mRNA and its effect on protein of API 2 , Caspase 3 and Ki 67 in gastrointestinal MALT lymphoma ( Extranodal marginal zone B cell lymphoma of mucosa associated lymphoid tissue ) . ^^^ Ki 67 , API 2 and Caspase 3 were detected by immunohistochemical technique and analyzed by the microsoft Image Pro plus . ^^^ The integrated optical density ( IOD ) of API 2 showed no significant difference between the two groups , neither did the expression of Ki 67 and Caspase 3 . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Using a heterologous yeast expression assay , we show that inhibitor of apoptosis proteins ( IAPs ) suppress caspase 3 mediated cytotoxicity in the order of XIAP > c IAP 2 > c IAP 1 > survivin . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NF kappaB transactivates c IAP 2 to inhibit caspase 3 activation . ^^^ This decrease in NF kappaB activation was accompanied by a reduction in c IAP 2 expression and an increase in the active form of caspase 3 protein . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| In conclusion , we demonstrate that the resistance to apoptosis in gastric cancer cells with elevated HO 1 and p 21 is independent of p 53 status in a p 38 MAPK and ERK mediated pathway with elevated c IAP 2 and decreased caspase 3 activity and that this pathway is sensitive to the inhibition of NF kappaB . . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| The up regulated genes include HIAP 1 , CRAF 1 , TRAF 6 , CASP 1 , CASP 2 , CASP 3 , CASP 4 , HPRT , GADD 45 , MCL 1 , NIP 1 , BCL2L2 , TRAP 3 , GSTP 1 , DAXX , PIG 11 , UBC , PIG 3 , PCNA , CDC 10 , JNK 1 and RBP 2 . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Human XIAP , cIAP 1 and cIAP 2 are direct inhibitors of at least two members of the caspase family of cell death proteases : caspase 3 and caspase 7 . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| LPS enhanced the expression of cIAP 2 mRNA and protein in human monocyte derived macrophages , which was associated with the inhibition of the caspase 3 activation , i . e . , decrease in active p 17 fragment of caspase 3 with simultaneous accumulation of precursor p 20 fragment . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| However , other proteins analyzed [ namely , Apaf 1 , Bax , Bid , caspase 3 , caspase 8 , caspase 9 , 10 linked inhibitor of apoptosis protein ( XIAP ) , cellular inhibitor of apoptosis protein ( cIAP ) 1 , cIAP 2 , cytochrome c , Fas , Fas ligand , FLIP , p 53 , and poly ( ADP ribose ) polymerase ] were not affected by either rituximab or cisplatin . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that AFP may regulate cell death by displacing cIAP 2 from the apoptosome , resulting in promotion of caspase 3 activation and its release from the complex . . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Endotoxin reduces CD 95 induced neutrophil apoptosis by cIAP 2 mediated caspase 3 degradation . ^^^ We investigated the turnover dynamics of cIAP 2 mRNA and caspase 3 protein in a neutrophil ex vivo model of sepsis . ^^^ Expression of ubiquitinated caspase 3 and cIAP 2 protein was detected by Western blot analysis and cIAP 2 mRNA by reverse transcriptase polymerase chain reaction . ^^^ CONCLUSIONS : Induction of cIAP 2 by endotoxins and accelerated degradation of activated caspase 3 by the proteasome might be responsible for reduced apoptosis in PMN during sepsis . . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Apigenin generated reactive oxygen species , a loss of mitochondrial Bcl 2 expression , mitochondrial permeability , cytochrome C release , and the cleavage of caspase 3 , 7 , 8 , and 9 and the concomitant cleavage of the inhibitor of apoptosis protein , cIAP 2 . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Elevated expression of BRF 1 decreased the level of the human inhibitor of apoptosis protein 2 ( cIAP 2 ) and increased the caspase 3 activity in HNSCC cells . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| Utilizing a cell free system in which caspase 3 was activated in eosinophil cytosolic extracts by addition of cytochrome c and immunodepletion of cIAP 2 or survivin resulted in accelerated caspase activation . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| We examined the expression profile of the caspases ( CASP 3 , 6 , 7 , 8 , 9 , 10 , and 14 ) , APAF 1 , SMAC , BCL 2 , the IAPs ( BIRC5 / survivin , CIAP 1 , CIAP 2 , XIAP , and LIVIN ) , and the proliferation markers Ki 67 and PHH 3 in 78 diffusely infiltrating astrocytomas and 24 normal brain samples by immunohistochemistry . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| The ability of IL 18 to regulate cell survival is not limited to a caspase death pathway in that IL 18 augments tumor necrosis factor ( TNF ) signaling , resulting in increased and prolonged mRNA expression of c apoptosis inhibitor 2 ( cIAP 2 ) , a prosurvival factor and caspase 3 inhibitor , and TNF receptor associated factor 1 ( TRAF 1 ) , a prosurvival protein . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| We have investigated the effects of expression of the viral proteins CrmA , P 35 and IAP , and the three mammalian IAP homologues ( MIHA , MIHB and MIHC ) , on the regulation of apoptosis induced by either the overexpression of caspases ( ICE , CPP 32 and Nedd 2 ) , by serum deprivation , or by gamma irradiation in NIH3T3 fibroblasts . ^^^ |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13489 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
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