| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| Furthermore , ROCK 1 cleavage , which is dependent on caspase 3 activity , was also increased in cells undergoing oxidative stress compared with normoxic cells . ^^^ |
|
| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| Both drugs also augmented the proteolytic cleavage of the Rho kinase ROCK 1 that was attenuated by the caspase 3 pathway inhibitor z DEVD fmk . ^^^ This was accompanied by proteolytic activation of ROCK 1 , through both caspase 3 dependent and independent mechanisms , as shown in caspase 3 deficient MCF 7 breast cancer cells . ^^^ |
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| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| Ethanol induces a ROCK 1 activation that is mediated by RhoA , rather than by caspase 3 cleavage . ^^^ |
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| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| Activation of Rho associated coiled coil protein kinase 1 ( ROCK 1 ) by caspase 3 cleavage plays an essential role in cardiac myocyte apoptosis . ^^^ Rho associated coiled coil protein kinase 1 ( ROCK 1 ) is a direct cleavage substrate of activated caspase 3 , which is associated with heart failure . ^^^ Murine cardiomyocytes treated with doxorubicin led to enhanced ROCK 1 cleavage and apoptosis , all of which was blocked by a caspase 3 inhibitor . ^^^ This constitutively active ROCK 1 subspecies , when expressed in cardiomyocytes , led to caspase 3 activation , indicating a positive feed forward regulatory loop . ^^^ ROCK 1 dependent caspase 3 activation was coupled with the activation of PTEN and the subsequent inhibition of protein kinase B ( Akt ) activity , all of which was attenuated by siRNA directed against ROCK 1 expression . ^^^ |
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| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13464 and P42574 |
Pubmed |
SVM Score :0.0 |
| NA |
|