| Interacting proteins: P08134 and Q13464 |
Pubmed |
SVM Score :0.0 |
| Correlation of expression of RhoA ( RhoC and their effector ROCK 1 with malignant phenotype of ovarian cancer cells in vitro ] . ^^^ OBJECTIVE : To investigate the expression of RhoA , RhoC and their effector ROCK 1 in four ovarian cancer cell lines in vitro and their correlation with invasiveness . ^^^ METHODS : Expression of RhoA , RhoC and ROCK 1 mRNA and protein in four ovarian cancer cell lines SW 626 , Skov 3 , A 2780 and Caov 3 was detected by RT PCR and Western blot assay . ^^^ RESULTS : The expression levels of RhoA , RhoC and ROCK 1 mRNA and protein varied in the four different cell lines examined . ^^^ The expression level of RhoC , but not RhoA and ROCK 1 , was significantly correlated with the invasive capability of these cells in vitro ( r = 0 . 95 , P < 0 . 01 ) . ^^^ |
|
| Interacting proteins: P08134 and Q13464 |
Pubmed |
SVM Score :0.0 |
| Elevated expression of RhoA and RhoC , as well as the Rho effector proteins ROCK 1 and ROCK 2 , are commonly observed in human cancers and are often associated with more invasive and metastatic phenotypes . ^^^ These results suggest that ROCK inhibitors would be useful antimetastatic and antiangiogenic chemotherapeutic agents in tumors associated with elevated RhoA , RhoC , ROCK 1 , or ROCK 2 expression . . ^^^ |
|
| Interacting proteins: P08134 and Q13464 |
Pubmed |
SVM Score :0.0 |
| The RhoA and RhoC proteins regulate numerous effector proteins , with a central and vital signaling role mediated by the ROCK 1 and ROCK 2 serine / threonine kinases . ^^^ |
|