| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Helios , a T cell restricted Ikaros family member that quantitatively associates with Ikaros at centromeric heterochromatin . ^^^ The p 70 gene , named Helios , encodes two protein isoforms with zinc finger domains exhibiting considerable homology to those within Ikaros proteins . ^^^ Helios and Ikaros recognize similar DNA sequences and , when overexpressed , Helios associates indiscriminately with the various Ikaros isoforms . ^^^ Although Ikaros is present in most hematopoietic cells , Helios was found primarily in T cells . ^^^ The relevance of the Ikaros Helios interaction in T cells is supported by the quantitative association of Helios with a fraction of the Ikaros . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Helios , a novel dimerization partner of Ikaros expressed in the earliest hematopoietic progenitors . ^^^ RESULTS : Here , we describe the cloning of an Ikaros related gene , Helios . ^^^ Analysis of the primary sequences of Helios , Ikaros and Aiolos revealed that the DNA binding , transcriptional activation and dimerization domains are functionally conserved . ^^^ Helios activated transcription from Ikaros DNA binding sites and could dimerize with itself , Ikaros or Aiolos . ^^^ Helios co localized with Ikaros and Aiolos proteins in macromolecular nuclear structures and formed stable complexes in vivo with the dominant negative version of Ikaros . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| A PCR amplification strategy that is based on regions of shared sequence identity in Ikaros multigene family members found in mammals and several other vertebrates has led to the recovery of cDNAs that represent the orthologues of Ikaros , Aiolos , Helios , and Eos in Raja eglanteria ( clearnose skate ) , a cartilaginous fish that is representative of an early divergence event in the phylogenetic diversification of the vertebrates . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Members of the Ikaros family of transcription factors , Ikaros , Aiolos , and Helios , are expressed in lymphocytes and have been implicated in controlling lymphoid development . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Genetic mapping and allelic loss analysis in mouse thymic lymphomas of Helios and Aiolos belonging to the Ikaros gene family . ^^^ Here we test whether Helios and Aiolos , two other members of the Ikaros gene family , are also involved in lymphomagenesis . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| The mammalian Ikaros like family of transcription factors consists of five members , Ikaros , Helios , Aiolos , Eos and Pegasus , of which the first three appear to be essential for lymphocyte development . ^^^ Phylogenetic analysis based on the alignable segments of the sequences does not identify the orthologous gene in jawed vertebrates but rather shows equidistance of the lamprey Ikaros like factors to each other and to Ikaros , Helios , Aiolos and Eos . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| In the present study , we analyzed expression of the Ikaros family genes Ikaros , Aiolos , and Helios in a panel of human T cell leukemia / lymphoma cell lines and bone marrow samples of patients with T cell acute lymphoblastic leukemia . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Finally , we show that , barring CtBP , the Ikaros family members Aiolos , Helios , and Eos can associate with all of the identified corepressors of Ikaros including its newly identified interactors , Class 2 HDACs . . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| The Ikaros ( Ik ) gene family , which includes Ik , Aiolos ( Ai ) , and Helios ( He ) , is a primary regulator of lymphocyte differentiation , and is involved in the development of acute lymphoblastic leukaemia ( ALL ) . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Identification and expression of Helios , a member of the Ikaros family , in the Mexican axolotl : implications for the embryonic origin of lymphocyte progenitors . ^^^ During ontogeny , Helios transcripts are detected from neurula stage , before the apparition of the first Ikaros transcripts and the colonization of lymphoid tissues . ^^^ Interestingly , Helios and Ikaros mRNA are found predominantly in the ventral blood islands of late tail bud embryos . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| By contrast , the 15 AA N terminal portion of Helios 3 is unique and does not contain the N terminal zinc finger motifs that are conserved in Helios 1 and 2 as well as other previously identified members of the Ikaros family . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Recently , we reported an over expression of the short isoforms of Helios , which is one of the members of the Ikaros gene family , in a patient with T cell ALL . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Ikaros , Aiolos and Helios : transcription regulators and lymphoid malignancies . ^^^ Ikaros , Aiolos and Helios encode zinc finger transcription factors that are important regulators of lymphoid development and differentiation . ^^^ Several reports reinforce the hypothesis that Ikaros , Aiolos and Helios expression is deregulated in human leukaemias . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Avian Helios and evolution of the Ikaros family . ^^^ Abstract Helios ( Znfn1a2 ) is an Ikaros related lymphoid regulatory protein with possible involvement in T cell development and function as well as in the early events of haematopoietic stem cell differentiation . ^^^ Furthermore , the avian Helios expression precedes Ikaros in the ontogeny , being present already on the first day of embryonic development . ^^^ |
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| Interacting proteins: Q9UKS7 and Q13422 |
Pubmed |
SVM Score :0.0 |
| Helios , a member of the Ikaros family of DNA binding proteins , is expressed in multipotential lymphoid progenitors and throughout the T lineage . ^^^ These alterations were observed even though the concentration of ectopic Helios in B lineage cells , like that of endogenous Helios in thymocytes , was well below the concentration of Ikaros . ^^^ |
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