| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.50219878 |
| A complex of PARVA with ILK and the LIM protein PINCH 1 is critical for cell survival in a variety of cells , including certain cancer cells , kidney podocytes and cardiac myocytes . 0.50219878^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| Although many intracellular proteins have been implicated in these processes , a new paradigm is emerging from biochemical and genetic studies that implicates integrin linked kinase ( ILK ) and its interacting proteins , such as CH ILKBP ( alpha parvin ) , paxillin , and PINCH in coupling integrins to the actin cytoskeleton and signaling complexes . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| Whereas alpha parvin is not expressed in hematopoietic cells , beta parvin is only found in myeloid cells and gamma parvin is present in both cells of the myeloid and lymphoid lineages , where it binds ILK . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| PINCH 1 is a widely expressed focal adhesion protein that forms a ternary complex with integrin linked kinase ( ILK ) and CH ILKBP / actopaxin / alpha parvin ( abbreviated as alpha parvin herein ) . ^^^ First , PINCH 1 and ILK , but not alpha parvin , are essential for prompt cell spreading and motility . ^^^ Second , PINCH 1 and ILK , like alpha parvin , are crucial for cell survival . ^^^ Fifth , PINCH 1 , ILK and to a less extent alpha parvin are mutually dependent in maintenance of their protein , but not mRNA , levels . ^^^ The coordinated down regulation of PINCH 1 , ILK , and alpha parvin proteins is mediated at least in part by proteasomes . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| We show here that CH ILKBP / actopaxin / alpha parvin and affixin / beta parvin ( abbreviated as alpha and beta parvin , respectively ) , two structurally closely related integrin linked kinase ( ILK ) binding focal adhesion proteins , are co expressed in human cells . ^^^ Overexpression of beta parvin , however , was insufficient for stimulation of Rac activation or lamellipodium formation , although it was sufficient for promotion of apoptosis , another important cellular process that is regulated by PINCH 1 , ILK , and alpha parvin . ^^^ Overexpression of beta parvin or its CH ( 2 ) fragment , but not a CH ( 2 ) deletion mutant , inhibited the ILK alpha parvin complex formation . ^^^ Finally , we provide evidence suggesting that inhibition of the ILK alpha parvin complex is sufficient , although not necessary , for promotion of apoptosis . ^^^ Furthermore , they demonstrate that alpha and beta parvins play distinct roles in mammalian cells and suggest that the formation of the ILK alpha parvin complex is crucial for protection of cells from apoptosis . . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| With the use of an inducible podocyte differentiation system , it was found that the cellular levels of PINCH 1 , integrin linked kinase ( ILK ) , and alpha parvin , cytoplasmic components of cell extracellular matrix adhesions , were significantly increased during podocyte differentiation . ^^^ Concomitantly , an increased amount of the PINCH 1 ILK alpha parvin complex was detected in the differentiated , foot process containing podocytes . ^^^ Overexpression of the PINCH 1 binding ankyrin repeat domain of ILK but not that of a PINCH 1 binding defective mutant form of the ankyrin domain effectively inhibited the formation of the PINCH 1 ILK alpha parvin complex . ^^^ Disruption of the PINCH 1 ILK alpha parvin complex significantly reduced the podocyte matrix adhesion and foot process formation . ^^^ Furthermore , a marked increase of apoptosis in the podocytes in which the assembly of the PINCH 1 ILK alpha parvin complex was compromised was detected . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| Taken together with the results that gamma parvin could form a complex with some important cytoskeletal proteins , such as alphaPIX , alpha actinin , and paxillin as demonstrated for affixin and actopaxin ( alpha parvin ) , the results in this study suggest that the ILK gamma parvin complex is critically involved in the initial integrin signaling for leukocyte migration . . ^^^ |
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| Interacting proteins: Q9NVD7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| NA |
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