| Interacting proteins: Q7Z4I7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| Characterization of PINCH 2 , a new focal adhesion protein that regulates the PINCH 1 ILK interaction , cell spreading , and migration . ^^^ We describe here a new LIM domain containing protein ( termed as PINCH 2 ) that forms a complex with ILK . ^^^ Deletion of the first LIM ( LIM 1 ) domain of PINCH 2 abolished the ability of PINCH 2 to form a complex with ILK . ^^^ The ILK binding defective LIM 1 deletion mutant , unlike the wild type PINCH 2 or the ILK binding competent LIM 5 deletion mutant , was incapable of localizing to cell ECM contact sites , suggesting that ILK binding is required for this process . ^^^ Importantly , the PINCH 2 ILK and PINCH 1 ILK interactions are mutually exclusive . ^^^ |
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| Interacting proteins: Q7Z4I7 and Q13418 |
Pubmed |
SVM Score :0.0 |
| Finally , increased expression of PINCH 2 , an ILK binding protein that is structurally related to PINCH 1 , prevented the down regulation of ILK and alpha parvin induced by the loss of PINCH 1 but failed to restore the survival signaling or cell shape modulation . ^^^ |
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