| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| CDC 45 also interacts genetically with ORC 2 , the gene encoding the second subunit of the origin recognition complex , ORC , and MCM 3 , another member of the MCM family . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| PKA was not required for the assembly of ORC 2 , Cdc 6 and MCM 3 onto chromatin . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| To investigate the events leading to initiation of DNA replication in mammalian chromosomes , the time when hamster origin recognition complexes ( ORCs ) became functional was related to the time when Orc 1 , Orc 2 and Mcm 3 proteins became stably bound to hamster chromatin . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| In G ( 1 ) , the pre replicative complex contains CDC 6 , MCM 3 , ORC 1 and ORC 2 proteins ; of these , the post replicative complex in S phase contains only ORC 2 ; in M phase none of them are bound . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| Chromatin immunoprecipitations and quantitative polymerase chain reaction analysis revealed that , in G 1 phase cells , Orc 1 and Orc 2 , as well as Mcm 3 , another component of the prereplication complex , are bound to multiple sites on the plasmid . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| The binding of the prereplication complex proteins Orc 1 , Orc 2 , Mcm 3 , Mcm 7 , and Cdc 6 and the novel DNA unwinding element ( DUE ) binding protein DUE B to the endogenous human c myc replicator was studied by chromatin immunoprecipitation . ^^^ In G ( 1 ) arrested HeLa cells , Mcm 3 , Mcm 7 , and DUE B were prominent near the DUE , while Orc 1 and Orc 2 were least abundant near the DUE and more abundant at flanking sites . ^^^ Similarly , the signals from Orc 1 , Mcm 3 , and Mcm 7 were at background levels in cells arrested in M phase , whereas Orc 2 retained the distribution seen in G ( 1 ) phase cells . ^^^ Previously shown to cause histone hyperacetylation and delocalization of replication initiation , trichostatin A treatment of cells led to a parallel qualitative change in the distribution of Mcm 3 , but not Orc 2 , across the c myc replicator . ^^^ Orc 2 , Mcm 3 , and DUE B were also bound at an ectopic c myc replicator , where deletion of sequences essential for origin activity was associated with the loss of DUE B binding or the alteration of chromatin structure and loss of Mcm 3 binding . ^^^ |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13416 and P25205 |
Pubmed |
SVM Score :0.0 |
| NA |
|