| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.64138956 |
| In addition , the UBC 13 conjugating enzyme was observed to interact with two different E2s , UEV 1 and UBC 1 . 0.64138956^^^ |
|
| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| Human Ubc 13 and Mms 2 ( or its homolog , Uev 1 ) form a unique ubiquitin conjugating enzyme ( Ubc ) complex that generates atypical Lys ( 63 ) linked ubiquitin conjugates . ^^^ |
|
| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| Peptide mass fingerprinting analysis reveals that this complex is composed of the ubiquitin conjugating enzyme Ubc 13 and the Ubc like protein Uev1A . ^^^ |
|
| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| TRIKA 1 is a dimeric ubiquitin conjugating enzyme complex composed of Ubc 13 and Uev1A ( or the functionally equivalent Mms 2 ) . ^^^ We find that the TAK 1 kinase complex phosphorylates and activates IKK in a manner that depends on TRAF 6 and Ubc 13 Uev1A . ^^^ |
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| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) induced germinal center kinase related ( GCKR ) and stress activated protein kinase ( SAPK ) activation depends upon the E2 / E3 complex Ubc 13 Uev1A / TNF receptor associated factor 2 ( TRAF 2 ) . ^^^ Here , we report that TNF activates GCKR and the SAPK pathway in a manner that depends upon TRAF 2 and Ubc 13 , a member along with Uev1A of a dimeric ubiquitin conjugating enzyme complex . ^^^ |
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| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| A protein heterodimer composed of a catalytically active ubiquitin conjugating enzyme ( Ubc 13 ) and its homologue ( Mms 2 or Uev1a ) forms a catalytic scaffold upon which a noncovalently associated acceptor Ub and thiolester linked donor Ub are oriented such that Lys ( 63 ) linked poly Ub chain synthesis is facilitated . ^^^ |
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| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| In human cells , the activation of TAK 1 and IKK requires the human ubiquitin conjugating enzymes Ubc 13 and UEV1a . ^^^ Here we demonstrate that the Drosophila homologs of Ubc 13 and UEV1a are similarly required for the activation of dTAK 1 and the DmIKK complex . ^^^ |
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| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| Distinct regulation of Ubc 13 functions by the two ubiquitin conjugating enzyme variants Mms 2 and Uev1A . ^^^ In this study , we demonstrate that divergent activities of mammalian Ubc 13 rely on its pairing with either of two Uevs , Uev1A or Mms 2 . ^^^ Structurally , we demonstrate that Mms 2 and Uev1A differentially modulate the length of Ubc 13 mediated Lys 63 linked polyubiquitin chains . ^^^ Functionally , we describe that Ubc 13 Mms2 is required for DNA damage repair but not nuclear factor kappaB ( NF kappaB ) activation , whereas Ubc 13 Uev1A is involved in NF kappaB activation but not DNA repair . ^^^ |
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| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13404 and P61088 |
Pubmed |
SVM Score :0.0 |
| NA |
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