| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| Although overexpression of PLD 1 is generally toxic to cells , the EGFR cells not only tolerated PLD 1 overexpression but also became transformed in the absence of EGF . ^^^ |
|
| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| Two specific PLD 1 isoforms , PLD1a and PLD1b , are shown in the present study to be localized in endosomal compartments with early endosomal autoantigen 1 , internalizing epidermal growth factor receptor ( ErbB 1 ) and lysobisphosphatidic acid . ^^^ |
|
| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| Consistent with a role in mitogenic signaling , elevated expression of PLD 1 transforms cells overexpressing the epidermal growth factor ( EGF ) receptor ( EGFR ) . ^^^ |
|
| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| We found that ADP ribosylation factor 4 ( ARF 4 ) interacts with the intracellular part of EGFR and mediates the EGF dependent cellular activation of phospholipase D 2 ( PLD 2 ) but does not mediate the activation of PLD 1 . ^^^ |
|
| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| In addition , the silencing of PLDs was shown to retard EGFR endocytosis and the addition of wild type PLDs or lipase inactive PLDs , but not PLD 1 mutants with defective GAP activity for dynamin in vitro , resulted in the recovery of EGFR endocytosis . ^^^ |
|
| Interacting proteins: Q13393 and P00533 |
Pubmed |
SVM Score :0.0 |
| NA |
|