| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.53516442 |
| Close anatomical association between major urocortin 3 terminal fields and CRFR 2 in hypothalamus , lateral septum , and medial amygdala ( MEA ) suggest it is well placed to modulate behavioral and hormonal responses to stress . 0.53516442^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Identification of urocortin 3 , an additional member of the corticotropin releasing factor ( CRF ) family with high affinity for the CRF 2 receptor . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 3 ( Ucn 3 ) or stresscopin ( SCP ) is a new member of the corticotropin releasing factor ( CRF ) neuropeptide family and is a specific ligand for CRF type 2 receptor ( CRF 2 ) . ^^^ Urocortin 3 ( Ucn 3 ) or stresscopin ( SCP ) is a new member of the corticotropin releasing factor ( CRF ) neuropeptide family and is a specific ligand for CRF type 2 receptor ( CRF 2 ) . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Similar to mammals , frog urocortin 3 is selective for the CRF 2 receptor . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Stresscopin , a CRF 2 receptor agonist , could not activate neurons at 10 ( 7 ) M , and its effect at 10 ( 6 ) M ( 15 . 3 % , n = 59 ) was completely blocked by CP 154 , 526 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Behavioral and neuroendocrine effects of the selective CRF 2 receptor agonists urocortin 2 and urocortin 3 . ^^^ We compared the in vivo efficacy of two selective CRF 2 agonists , mouse urocortin 2 ( mUcn 2 ) and human urocortin 3 ( hUcn 3 ) , using food intake , anxious behavior , or ACTH release in CD 1 or Balb / c mice as indices of biological stress responses . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The role of the CRF 2 receptor in the regulation of these behaviors during the early stages of withdrawal was examined via central injection of the highly selective CRF 2 receptor agonist urocortin 3 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Recently , UcnII and UcnIII have been discovered as potential endogenous agonists selective for CRF 2 known to be involved in brain functions such as learning and anxiety , as well as in cardiovascular functions . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) and Ucn 3 are new members of the corticotropin releasing factor ( CRF ) family and bind selectively to the CRF type 2 receptor ( CRF 2 ) . ^^^ These results suggest that the CRF 2 receptor is involved in motor suppressive effects as well as anxiolytic and anorectic effects of Ucn 2 and Ucn 3 . . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| In addition to urocortin ( Ucn 1 ) , Ucn 2 and Ucn 3 were identified as endogenous ligands for corticotropin releasing factor type 2 receptor ( CRF 2 receptor ) . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 binds with high affinity to CRF type 1 ( CRF 1 ) and type 2 ( CRF 2 ) receptors while Ucn 2 and Ucn 3 are selective CRF 2 ligands . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Endogenous agonists ( urocortin ( UCN ) 2 , UCN 3 ) and synthetic antagonists ( astressin 2 B , antisauvagine 30 ) are selective for CRF 2 over the CRF 1 receptor . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Ucn 1 binds to both CRF type 1 ( CRF 1 ) and type 2 receptors ( CRF 2 ) , whereas Ucn 3 is a specific agonist for CRF 2 . ^^^ Immunohistochemistry in serial tissue sections with mirror images revealed that both Ucn 3 and CRF 2 were colocalized in more than 85 % of the adrenocortical cells . mRNA in situ hybridization confirmed these findings above . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Urocortin ( Ucn ) 3 , or stresscopin , is a high affinity ligand for the type 2 corticotropin releasing factor ( CRFR 2 ) receptor recently identified in rodents and human . ^^^ The observed effects of Ucn 3 were blocked by pretreatment with a CRFR 2 antagonist , astressin ( 2 ) B . ^^^ Furthermore , Ucn 3 stimulated glucagon and insulin release from isolated rat islets , and astressin ( 2 ) B abolished the effects of Ucn 3 , in keeping with a CRFR 2 mediated mechanism . ^^^ Taken together , the present studies suggest pancreatic Ucn 3 acting through CRFR 2 is involved in the local regulation of glucagon and insulin secretion . . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| UCN is able to bind to two types of G protein coupled receptors : CRF receptor type 1 ( CRFR 1 ) and CRF receptor type 2 ( CRFR 2 ) , whereas , two homologues of UCN , stresscopin ( SCP ) or also known as urocortin 3 ( UCNIII ) and stresscopin related peptide ( SRP ) , or urocortin 2 ( UCNII ) , bind exclusively and with high affinity to CRFR 2 , we hypothesised that they will exhibit more pronounced cardioprotective effects than UCN . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Urocortin 3 ( UCN 3 ) , a highly selective ligand for CRF 2 receptor with little affinity for CRF 1 receptor , has been shown in rat pancreatic beta cells . ^^^ Urocortin 3 ( UCN 3 ) , a highly selective ligand for CRF 2 receptor with little affinity for CRF 1 receptor , has been shown in rat pancreatic beta cells . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Pharmacological studies showed that Ucn 3 is a high affinity ligand for the type 2 CRF receptor ( CRF R 2 ) . ^^^ Several major Ucn 3 terminal fields identified in the present study , including the lateral septum and the ventromedial hypothalamus , are known to express high levels of CRF R 2 . ^^^ Thus , these anatomical data strongly support the notion that Ucn 3 is an endogenous ligand for CRF R 2 in these areas . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The three urocortins have considerably higher affinities for CRF receptor type 2 ( CRF R 2 ) than CRF , and urocortin 2 and urocortin 3 are highly selective for CRF R 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Human urocortin 3 ( hUCN 3 ) , a CRF receptor type 2 ( CRF R 2 ) specific agonist enhanced the release of TSH from the pituitary cells in culture , suggesting the involvement of CRF R 2 in the CRF induced TSH release in the bullfrogs . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The involvement of this CRH receptor in the response of thyrotropes to CRH was further confirmed by the fact that TSH release was stimulated by human urocortin 3 , a CRH R 2 specific agonist , whereas the TSH response to CRH was completely blocked by the CRH R blocker astressin and the CRH R 2 specific antagonist antisauvagine 30 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| Adipose tissue also expressed urocortin and stresscopin , the predominant ligands of peripheral CRH R 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| CRF mRNA levels are elevated in CRFR 1 and double mutant mice , and urocortin 3 and vasopressin mRNA levels are increased in CRFR 2 and double mutant mice . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The CRFR 2 selective antagonist astressin 2 B and an ERK1 / 2 p 42 , 44 inhibitor abolish the cardioprotective actions of Ucn 2 and Ucn 3 in reperfusion . ^^^ We propose the use of CRFR 2 selective agonists , Ucn 2 and Ucn 3 , to treat ischemic heart disease because of their potent cardioprotective effects in the murine heart and their minimal impact on the hypothalamic stress axis . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The mammalian family members include CRF , urocortinI ( UcnI ) , UcnII , and UcnIII , along with two receptors , CRFR 1 and CRFR 2 , and a CRF binding protein . ^^^ Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR 1 , specific actions of UcnII and UcnIII on CRFR 2 may be important for dampening stress sensitivity . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| The UCN homologues SCP and SRP bind specifically to the CRFR 2 receptor , whereas UCN binds to both CRFR 1 and CRFR 2 . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| ICV infusion of the CRF receptor subtype CRFR 2 selective agonists urocortin 2 and 3 ( UCN 2 , UCN 3 ) inhibited sexual receptivity in hormone primed , ovariectomized hamsters . ^^^ |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13324 and Q969E3 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.53516442 |
| Close anatomical association between major urocortin 3 terminal fields and CRFR 2 in hypothalamus , lateral septum , and medial amygdala ( MEA ) suggest it is well placed to modulate behavioral and hormonal responses to stress . 0.53516442^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin ( Ucn ) 3 , or stresscopin , is a high affinity ligand for the type 2 corticotropin releasing factor ( CRFR 2 ) receptor recently identified in rodents and human . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| UCN is able to bind to two types of G protein coupled receptors : CRF receptor type 1 ( CRFR 1 ) and CRF receptor type 2 ( CRFR 2 ) , whereas , two homologues of UCN , stresscopin ( SCP ) or also known as urocortin 3 ( UCNIII ) and stresscopin related peptide ( SRP ) , or urocortin 2 ( UCNII ) , bind exclusively and with high affinity to CRFR 2 , we hypothesised that they will exhibit more pronounced cardioprotective effects than UCN . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Adipose tissue also expressed urocortin and stresscopin , the predominant ligands of peripheral CRH R 2 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 3 ( Ucn 3 ) or stresscopin ( SCP ) is a new member of the corticotropin releasing factor ( CRF ) neuropeptide family and is a specific ligand for CRF type 2 receptor ( CRF 2 ) . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Stresscopin , a CRF 2 receptor agonist , could not activate neurons at 10 ( 7 ) M , and its effect at 10 ( 6 ) M ( 15 . 3 % , n = 59 ) was completely blocked by CP 154 , 526 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Pharmacological studies showed that Ucn 3 is a high affinity ligand for the type 2 CRF receptor ( CRF R 2 ) . ^^^ Several major Ucn 3 terminal fields identified in the present study , including the lateral septum and the ventromedial hypothalamus , are known to express high levels of CRF R 2 . ^^^ Thus , these anatomical data strongly support the notion that Ucn 3 is an endogenous ligand for CRF R 2 in these areas . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The CRFR 2 selective antagonist astressin 2 B and an ERK1 / 2 p 42 , 44 inhibitor abolish the cardioprotective actions of Ucn 2 and Ucn 3 in reperfusion . ^^^ We propose the use of CRFR 2 selective agonists , Ucn 2 and Ucn 3 , to treat ischemic heart disease because of their potent cardioprotective effects in the murine heart and their minimal impact on the hypothalamic stress axis . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 2 ( Ucn 2 ) and Ucn 3 are new members of the corticotropin releasing factor ( CRF ) family and bind selectively to the CRF type 2 receptor ( CRF 2 ) . ^^^ These results suggest that the CRF 2 receptor is involved in motor suppressive effects as well as anxiolytic and anorectic effects of Ucn 2 and Ucn 3 . . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| In addition to urocortin ( Ucn 1 ) , Ucn 2 and Ucn 3 were identified as endogenous ligands for corticotropin releasing factor type 2 receptor ( CRF 2 receptor ) . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 1 binds with high affinity to CRF type 1 ( CRF 1 ) and type 2 ( CRF 2 ) receptors while Ucn 2 and Ucn 3 are selective CRF 2 ligands . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Endogenous agonists ( urocortin ( UCN ) 2 , UCN 3 ) and synthetic antagonists ( astressin 2 B , antisauvagine 30 ) are selective for CRF 2 over the CRF 1 receptor . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| ICV infusion of the CRF receptor subtype CRFR 2 selective agonists urocortin 2 and 3 ( UCN 2 , UCN 3 ) inhibited sexual receptivity in hormone primed , ovariectomized hamsters . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Ucn 1 binds to both CRF type 1 ( CRF 1 ) and type 2 receptors ( CRF 2 ) , whereas Ucn 3 is a specific agonist for CRF 2 . ^^^ Immunohistochemistry in serial tissue sections with mirror images revealed that both Ucn 3 and CRF 2 were colocalized in more than 85 % of the adrenocortical cells . mRNA in situ hybridization confirmed these findings above . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Urocortin 3 ( UCN 3 ) , a highly selective ligand for CRF 2 receptor with little affinity for CRF 1 receptor , has been shown in rat pancreatic beta cells . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Identification of urocortin 3 , an additional member of the corticotropin releasing factor ( CRF ) family with high affinity for the CRF 2 receptor . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| CRF mRNA levels are elevated in CRFR 1 and double mutant mice , and urocortin 3 and vasopressin mRNA levels are increased in CRFR 2 and double mutant mice . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The involvement of this CRH receptor in the response of thyrotropes to CRH was further confirmed by the fact that TSH release was stimulated by human urocortin 3 , a CRH R 2 specific agonist , whereas the TSH response to CRH was completely blocked by the CRH R blocker astressin and the CRH R 2 specific antagonist antisauvagine 30 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The three urocortins have considerably higher affinities for CRF receptor type 2 ( CRF R 2 ) than CRF , and urocortin 2 and urocortin 3 are highly selective for CRF R 2 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Behavioral and neuroendocrine effects of the selective CRF 2 receptor agonists urocortin 2 and urocortin 3 . ^^^ We compared the in vivo efficacy of two selective CRF 2 agonists , mouse urocortin 2 ( mUcn 2 ) and human urocortin 3 ( hUcn 3 ) , using food intake , anxious behavior , or ACTH release in CD 1 or Balb / c mice as indices of biological stress responses . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The role of the CRF 2 receptor in the regulation of these behaviors during the early stages of withdrawal was examined via central injection of the highly selective CRF 2 receptor agonist urocortin 3 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Human urocortin 3 ( hUCN 3 ) , a CRF receptor type 2 ( CRF R 2 ) specific agonist enhanced the release of TSH from the pituitary cells in culture , suggesting the involvement of CRF R 2 in the CRF induced TSH release in the bullfrogs . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Similar to mammals , frog urocortin 3 is selective for the CRF 2 receptor . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The UCN homologues SCP and SRP bind specifically to the CRFR 2 receptor , whereas UCN binds to both CRFR 1 and CRFR 2 . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| The mammalian family members include CRF , urocortinI ( UcnI ) , UcnII , and UcnIII , along with two receptors , CRFR 1 and CRFR 2 , and a CRF binding protein . ^^^ Although CRF appears to play a stimulatory role in stress responsivity through activation of CRFR 1 , specific actions of UcnII and UcnIII on CRFR 2 may be important for dampening stress sensitivity . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| Recently , UcnII and UcnIII have been discovered as potential endogenous agonists selective for CRF 2 known to be involved in brain functions such as learning and anxiety , as well as in cardiovascular functions . ^^^ |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q969E3 and Q13324 |
Pubmed |
SVM Score :0.0 |
| NA |
|