| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| Using cell viability assay , we established the optimal in vitro inhibitory dose of celecoxib and showed that inhibition of COX 2 markedly induces the expression of p27kip1 , p 21 , waf 1 , and the F box protein skp 2 . ^^^ |
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| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| As for this mechanism , GATA 2 was found to inhibit ubiquitin / proteasome dependent degradation of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) and to induce their accumulation by repressing the expression of Skp 2 and Cul 1 , both of which are components of the ubiquitin ligase for p 21 ( WAF 1 ) and p 27 ( Kip 1 ) . ^^^ Overexpression of c myc restored the expression of Skp 2 and Cul 1 mRNA , reduced the amounts of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) proteins , and canceled GATA 2 induced growth suppression , suggesting that down regulation of c myc expression may be primarily responsible for GATA 2 induced growth suppression . ^^^ GATA 2 / ER suppressed cytokine dependent growth of MNCs and Sca 1 ( + ) Lin ( ) cells by about 70 % , which was also accompanied by the reduced expression of c myc , Skp 2 , and Cul 1 mRNA and the accumulation of p 21 ( WAF 1 ) and p 27 ( Kip 1 ) proteins . ^^^ |
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| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| Overexpression of SKP 2 reduced the expression of p27Kip1 , cyclin E , and p21Cip1 , increased S phase cells , rescued A 549 cells from apoptosis due to adenoviral infection , and also increased chemoresistance against camptothecin , cisplatin , and AG 1478 . ^^^ |
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| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| Biphasic effect of p21Cip1 on smooth muscle cell proliferation : role of PI 3 kinase and Skp 2 mediated degradation . ^^^ METHODS AND RESULTS : We studied the S phase associated kinase protein 2 ( Skp 2 ) , an F box protein implicated in the ubiquitination of p21Cip1 . ^^^ Overexpression of wild type Skp 2 or dominant negative Skp 2 decreased or increased p21Cip1 levels , respectively . ^^^ Interestingly , levels of endogenous p21Cip1 and Skp 2 were both increased in a phosphoinositide PI 3 kinase dependent manner in late G 1 phase . ^^^ Increased expression of p21Cip1 occurred despite significantly increased Skp 2 mediated proteasomal degradation . ^^^ |
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| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13309 and P38936 |
Pubmed |
SVM Score :0.0 |
| NA |
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