| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :1.0540904 |
| Recombinant G3BP binds effectively to the GAP SH 3 domain G3BP coimmunoprecipitates with GAP only when cells are in a proliferating state , suggesting a recruitment of a GAP G3BP complex when Ras is in its activated conformation . . 1.0540904^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.55763026 |
| In addition , HRG stimulation of breast cancer cells promoted phosphorylation of G3BP and increased the association of G3BP with GTPase activating protein , both of which are essential for G3BP activity . 0.55763026^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.53878749 |
| Here , we show that G3BP , a phosphorylation dependent endoribonuclease that interacts with RasGAP , is recruited to SGs in cells exposed to arsenite . 0.53878749^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| The newly found GAP SH 3 domain Binding Protein ( G3BP ) may be one of these . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| A potential p 120 GTPase activating protein ( RasGAP ) effector , G3BP ( RasGAP Src homology 3 [ SH 3 ] binding protein ) , was previously identified based on its ability to bind the SH 3 domain of RasGAP . ^^^ Here we show that G3BP colocalizes and physically interacts with RasGAP at the plasma membrane of serum stimulated but not quiescent Chinese hamster lung fibroblasts . ^^^ The endoribonuclease activity of G3BP can initiate mRNA degradation and therefore represents a link between a RasGAP mediated signaling pathway and RNA turnover . . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| Microsequencing of the polypeptide showed that this enzyme corresponds to G3BP , an element of the Ras pathway which binds specifically to the GTPase activating protein . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| Upregulation of the RAS GTPase activating protein ( GAP ) binding protein ( G3BP ) in proliferating RPE cells . ^^^ Sequence alignment displayed its identity with the 3 ' end of the coding sequence of the human RAS GTPase activating protein ( GAP ) binding protein ( G3BP ) . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| We have identified and characterized the Drosophila homologue of the RasGAP binding protein G3BP encoded by rasputin ( rin ) . rin mutants are viable and display defects in photoreceptor recruitment and ommatidial polarity in the eye . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| The expression of the human Ras GTPase activating protein ( GAP ) binding protein ( G3BP ) was studied in human tumors and cell lines of different origins . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| Here , we report that the middle domain of TAP is also similar to NTF 2 , as well as to regions in Ras GAP SH 3 domain binding protein ( G3BP ) and some plant protein kinases . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| RasGAP associated endoribonuclease G3Bp : selective RNA degradation and phosphorylation dependent localization . ^^^ Mitogen activation of mRNA decay pathways likely involves specific endoribonucleases , such as G3BP , a phosphorylation dependent endoribonuclease that associates with RasGAP in dividing but not quiescent cells . ^^^ Interestingly , c myc mRNA decay is delayed in RasGAP deficient fibroblasts , which contain a defective isoform of G3BP that is not phosphorylated at serine 149 . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| We mapped the rasGAP ( 120 ) interactive region of the G3BP 2 isoforms and show that both G3BP 2a and G3BP 2b use an N terminal NTF 2 like domain for rasGAP ( 120 ) binding rather than several available proline rich ( PxxP ) motifs found in members of the G3BPs . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| Instead , Csk becomes associated with an approximately 72 kDa tyrosine phosphorylated protein , which we identify here as G3BP , a phosphoprotein reported to bind the SH 3 domain of Ras GTPase activating protein . ^^^ |
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| Interacting proteins: Q13283 and P20936 |
Pubmed |
SVM Score :0.0 |
| This appeared to be provoked by the release of cdk 7 mRNA from RasGAP SH 3 domain binding protein , G3BP , and its subsequent degradation . ^^^ Thus , we propose that the physical interaction between RasGAP and FLN C facilitates an interaction between G3BP and cdk 7 mRNA . ^^^ |
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