| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 2 , a novel member of the neuropilin family , is a high affinity receptor for the semaphorins Sema E and Sema 4 but not Sema 3 . ^^^ Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Here , we show that neuropilin 2 is a receptor for the secreted semaphorin Sema 4 and acts selectively to mediate repulsive guidance events in discrete populations of neurons . neuropilin 2 and semaIV are expressed in strikingly complementary patterns during neurodevelopment . ^^^ The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| To examine whether semaphorins could modulate VEGF endothelial cell guidance cues in the developing kidney , we studied the expression of semaphorin 3A and semaphorin 3F and their receptors NP 1 and NP 2 in the kidney during ontogeny using Northern blot analysis , in situ hybridization , Western blot analysis and immunohistochemistry . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Several class 3 semaphorins , including semaphorin 3F ( Sema3F ) bind to the receptor neuropilin 2 to confer chemorepulsive responses in vitro . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| We have found that semaphorin 3F ( s3f ) , a semaphorin which signals through the np 2 receptor , was able to inhibit VEGF ( 165 ) , as well as bFGF induced proliferation of HUVECs . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| We now report that in cultured rat Schwann cells , expression of mRNA encoding neuropilin 2 ( NRP 2 ) and plexin A 3 ( PlexA 3 ) , proteins involved in semaphorin 3F ( Sema3F ) signal transduction , is diminished markedly by forskolin , an adenylate cyclase activator that , like axonal contact , induces Schwann cell synthesis of myelin lipids and proteins . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin 1 in the genome , neuropilin 2 . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Semaphorin 3F ( s3f ) , an np 2 ligand , bound to np 2 expressing cells in 26 somite embryos regardless of the presence or absence of plexin A 1 or plexin A 2 . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Our results support the hypothesis that disruption of transcriptional regulation of axon guidance genes leads to a differential loss of tonic neuropilin 2 dependent activation of semaphorin 3F receptors on hippocampal neurons on distinct genetic backgrounds . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Guidance of trunk neural crest migration requires neuropilin 2 / semaphorin 3F signaling . ^^^ We demonstrate that neural crest cells express the receptor neuropilin 2 ( Npn 2 ) , while its repulsive ligand semaphorin 3F ( Sema3f ) is restricted to the posterior half somite . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Our results show that neuropilin 2 is an essential component of the Sema3F receptor and identify key roles for neuropilin 2 in axon guidance in the PNS and CNS . . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Although SEMA3F binds NRP 2 with 10 fold greater affinity than NRP 1 , the effects in MCF 7 were mediated by NRP 1 . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Two receptors , neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) , bind class 3 semaphorins , axon guidance molecules including SEMA3F , the gene for which was isolated from a 3p21 . 3 deletion in lung cancer . ^^^ Expression of VEGF , semaphorin SEMA3F , and their common receptors neuropilins NP 1 and NP 2 in preinvasive bronchial lesions , lung tumours , and cell lines . ^^^ Elevated VEGF levels are associated with the loss and cytoplasmic delocalization of SEMA3F in lung cancer , suggesting competition for their NP 1 and NP 2 receptors . ^^^ To determine the timing of these events , we compared by immunohistochemistry VEGF , SEMA3F , NP 1 and NP 2 expression in 50 preneoplastic lesions and 112 lung tumours . ^^^ Migrating cells overexpressed VEGF , SEMA3F , NP 1 and NP 2 with cytoplasmic delocalization of NP 1 as demonstrated in an in vitro wound assay . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| The neuropilins , NP 1 and NP 2 , are coreceptors for Sema3A and Sema3F , respectively , both of which are repulsive axonal guidance molecules . ^^^ Neurol . 172 ( 2001 ) 398 ) that VEGF mRNA levels rise during Wallerian degeneration in the PNS and herein demonstrate that NP 1 , NP 2 , Sema3A , and Sema3F mRNA levels increase in peripheral nerves distal to a transection or crush injury . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| In chick embryos , neuropilin 2 was expressed in the neuroepithelium of the dorsal isthmus in addition to the trochlear neurons , and Sema3F transcripts were localized along the caudal margin of the midbrain . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Consistent with semaphorin mediated chemorepulsion of neurons , tumor cells expressing SEMA3F were chemorepulsive for vascular and lymphatic endothelial cells expressing neuropilin 2 ( NRP 2 ) , a novel mechanism for a tumor angiogenesis inhibitor . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin 1 and Neuropilin 2 , respectively . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| In the motile breast cancer cell line C 100 , which expresses both neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors , SEMA3F had a repulsive effect , which was blocked by anti NRP 2 antibody . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Antisense morpholino knockdown of Sema3F / 3G or Nrp 2 suppresses the abnormal cranial NC phenotype of lzr / pbx4 mutants , demonstrating that aberrant Sema3F / 3G Nrp 2 signaling is responsible for this phenotype and suggesting that repulsive Sema3F / 3G Npn 2 signaling normally contributes to the guidance of migrating cranial NCCs . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| Although both antagonize VEGF binding / response to neuropilin ( NRP ) receptors , in lung cancer lines , SEMA3F is predominantly expressed and preferentially utilizes NRP 2 . ^^^ In H 460 cells , which express NRP 1 but not NRP 2 , SEMA3F did not prolong survival . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NrCAM , an immunoglobulin superfamily adhesion molecule of the L 1 subfamily , associates with neuropilin 2 and is a component of a receptor complex for Sema3B and Sema3F . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| For example , SEMA3F , which binds specifically to NRP 2 , inhibits tumor angiogenesis and metastasis . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| In contrast , SEMA3F , another ligand for NRP 2 , was able to inhibit human endothelial cell survival and migration induced by VEGF A and VEGF C . ^^^ |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
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