| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| The secreted semaphorins Sema 3 and Sema 4 and their receptors Neuropilin 1 and 2 are expressed in the hippocampal formation during appropriate stages . ^^^ An antibody against Neuropilin 1 blocks the repulsive action of Sema 3 and the entorhinal cortex , but has no effect on Sema 4 induced repulsion . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ In support of this , we show that sympathetic axons coexpress neuropilin 1 and 2 , that their responses to Sema 3 , Sema E , and Sema 4 are affected in predicted ways by antibodies to neuropilin 1 , and that neuropilin 1 and 2 can form homo and heterooligomers through an interaction involving at least partly the neuropilin MAM ( meprin , A 5 , mu ) domain . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| This suggests that vascular endothelial growth factor might compete with SEMA3F for binding to their common receptors , neuropilin 1 and 2 and might contribute to SEMA3F delocalization and deregulation in lung tumor . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Two receptors , neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) , bind class 3 semaphorins , axon guidance molecules including SEMA3F , the gene for which was isolated from a 3p21 . 3 deletion in lung cancer . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin 1 in the genome , neuropilin 2 . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin 1 and Neuropilin 2 , respectively . ^^^ Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro , and defects in axonal projections in vivo correspond to those seen in Neuropilin 1 and 2 mutants . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| In the motile breast cancer cell line C 100 , which expresses both neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors , SEMA3F had a repulsive effect , which was blocked by anti NRP 2 antibody . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| During lung tumorigenesis , both NRP and VEGF expression increase on dysplastic lung epithelial cells ; SEMA3F expression is reduced and SEMA3F protein is delocalized from the membrane to the cytoplasm . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Although both antagonize VEGF binding / response to neuropilin ( NRP ) receptors , in lung cancer lines , SEMA3F is predominantly expressed and preferentially utilizes NRP 2 . ^^^ In H 460 cells , which express NRP 1 but not NRP 2 , SEMA3F did not prolong survival . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| For example , SEMA3F , which binds specifically to NRP 2 , inhibits tumor angiogenesis and metastasis . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| Although SEMA3F binds NRP 2 with 10 fold greater affinity than NRP 1 , the effects in MCF 7 were mediated by NRP 1 . ^^^ |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O14786 and Q13275 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| The secreted semaphorins Sema 3 and Sema 4 and their receptors Neuropilin 1 and 2 are expressed in the hippocampal formation during appropriate stages . ^^^ An antibody against Neuropilin 1 blocks the repulsive action of Sema 3 and the entorhinal cortex , but has no effect on Sema 4 induced repulsion . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ In support of this , we show that sympathetic axons coexpress neuropilin 1 and 2 , that their responses to Sema 3 , Sema E , and Sema 4 are affected in predicted ways by antibodies to neuropilin 1 , and that neuropilin 1 and 2 can form homo and heterooligomers through an interaction involving at least partly the neuropilin MAM ( meprin , A 5 , mu ) domain . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Semaphorin 3F stimulates growth cone collapse following binding to the closest relative to neuropilin 1 in the genome , neuropilin 2 . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| This suggests that vascular endothelial growth factor might compete with SEMA3F for binding to their common receptors , neuropilin 1 and 2 and might contribute to SEMA3F delocalization and deregulation in lung tumor . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| During lung tumorigenesis , both NRP and VEGF expression increase on dysplastic lung epithelial cells ; SEMA3F expression is reduced and SEMA3F protein is delocalized from the membrane to the cytoplasm . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although SEMA3F binds NRP 2 with 10 fold greater affinity than NRP 1 , the effects in MCF 7 were mediated by NRP 1 . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Two receptors , neuropilin 1 ( NP 1 ) and neuropilin 2 ( NP 2 ) , bind class 3 semaphorins , axon guidance molecules including SEMA3F , the gene for which was isolated from a 3p21 . 3 deletion in lung cancer . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| The class 3 Semaphorins Sema3A and Sema3F are potent axonal repellents that cause repulsion by binding Neuropilin 1 and Neuropilin 2 , respectively . ^^^ Sensory and sympathetic neurons from the double mutant are insensitive to Sema3A and Sema3F in vitro , and defects in axonal projections in vivo correspond to those seen in Neuropilin 1 and 2 mutants . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| In the motile breast cancer cell line C 100 , which expresses both neuropilin 1 ( NRP 1 ) and neuropilin 2 ( NRP 2 ) receptors , SEMA3F had a repulsive effect , which was blocked by anti NRP 2 antibody . ^^^ In less motile MCF 7 cells , which express only NRP 1 , SEMA3F inhibited cell contacts with loss of membrane associated E cadherin and beta catenin without motility induction . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| Although both antagonize VEGF binding / response to neuropilin ( NRP ) receptors , in lung cancer lines , SEMA3F is predominantly expressed and preferentially utilizes NRP 2 . ^^^ In H 460 cells , which express NRP 1 but not NRP 2 , SEMA3F did not prolong survival . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| For example , SEMA3F , which binds specifically to NRP 2 , inhibits tumor angiogenesis and metastasis . ^^^ |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13275 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|