| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.62392751 |
| Coimmunoprecipitation indicates that Shank , a postsynaptic density protein associated with mGluRs , formed a complex involving PSD 95 ( postsynaptic density 95 ) , NR2B , and Src in the spinal dorsal horn . 0.62392751^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Homer 1b , a Shank interacting protein that is linked to group 1 metabotropic glutamate receptors and IP 3 receptors , forms a multiple complex with Shank 2 and PLC beta 3 . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Homer EVH 1 ( Ena / VASP Homology 1 ) domains interact with proline rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors ( mGluRs ) , inositol 1 , 4 , 5 trisphosphate receptors ( IP3Rs ) , and Shank proteins . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The proteins of the Homer family bind to proline rich sequences in group 1 metabotropic glutamate receptors , inositol trisphosphate receptors , ryanodine receptors , and Shank family proteins . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The Shank family of proteins interacts with NMDA receptor and metabotropic glutamate receptor complexes in the postsynaptic density ( PSD ) . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A recently identified family of multidomain proteins termed Src homology 3 domain and ankyrin repeat containing ( Shank ) , also known as proline rich synapse associated protein / somatostatin receptor interacting protein , plays a central role in organizing the subsynaptic scaffold by interacting with several synaptic proteins including the glutamate receptors . ^^^ Our data indicate that the Shank 1 and 3 family members provide multiple independent connections between synaptic glutamate receptor complexes and the cytoskeleton . . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PSD Zip45 / Homer1c , which contains an enabled / VASP homology 1 ( EVH 1 ) domain and leucine zipper motifs , is a postsynaptic density ( PSD ) scaffold protein that interacts with metabotropic glutamate receptors and the shank family . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Cellular signaling proteins such as metabotropic glutamate receptors , Shank , and different types of ion channels are physically linked by Vesl ( VASP / Ena related gene up regulated during seizure and LTP ) / Homer proteins [ Curr . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The Shank family of scaffolding proteins contain PDZ ( PSD 95 , Dlg , and ZO 1 ) domains and have been implicated in the localizations of many receptor proteins including glutamate receptors in mammals . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| One of them , Shank , which is a secondary and tertiary partner of metabotropic and ionotropic glutamate receptors , respectively , can induce the formation of a whole functional glutamate ' receptosome ' and the structure to which it is associated , the dendritic spine . . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Shank proteins assemble glutamate receptors with their intracellular signaling apparatus and cytoskeleton at the postsynaptic density . ^^^ Transfected Shank protein recruits functional glutamate receptors , increases the number and size of synaptic contacts , and increases amplitude , frequency , and the AMPA component of miniature EPSCs , similar to what is observed during synapse developmental maturation . ^^^ Mutation / deletion approaches indicate that these effects require interactions of Shank 3 with the glutamate receptor complex . ^^^ Consistent with this observation , chronic treatment with glutamate receptor antagonists alters maturation of the Shank 3 induced spines . ^^^ These results strongly suggest that Shank proteins and the associated glutamate receptors participate in a concerted manner to form spines and functional synapses . . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Within multiprotein signaling complexes , Vesl / Homer proteins influence proteins as diverse as metabotropic glutamate receptors ; transient receptor potential channels ; intra cellular calcium channels ; the scaffolding protein , Shank ; small GTPases ; transcription factors ; and cytoskeletal proteins . ^^^ |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UPX8 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|