| Interacting proteins: Q9P2E2 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Experiments with vesicles containing N methyl D aspartate ( NMDA ) receptor 2B ( NR2B subunit ) show that they are transported along microtubules by KIF 17 , a neuron specific molecular motor in neuronal dendrites . ^^^ Selective transport is accomplished by direct interaction of the KIF 17 tail with a PDZ domain of mLin 10 ( Mint1 / X11 ) , which is a constituent of a large protein complex including mLin 2 ( CASK ) , mLin 7 ( MALS / Velis ) , and the NR2B subunit . ^^^ |
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| Interacting proteins: Q9P2E2 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our results suggest that the motor protein KIF 17 contributes to neuronal events required for learning and memory by trafficking fundamental N methyl d aspartate type glutamate receptors . . ^^^ KIF 17 transports the N methyl d aspartate receptor NR2B subunit in vitro , but its role in vivo is unknown . ^^^ The KIF 17 transgenic mice exhibited enhanced learning and memory in a series of behavioral tasks , up regulated NR2B expression with the potential involvement of a transcriptional factor , the cAMP dependent response element binding protein , and increased phosphorylation of the cAMP dependent response element binding protein . ^^^ |
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| Interacting proteins: Q9P2E2 and Q13224 |
Pubmed |
SVM Score :0.0 |
| KIF 17 dynamics and regulation of NR2B trafficking in hippocampal neurons . ^^^ KIF 17 , a recently characterized member of the kinesin superfamily proteins , has been proposed to bind in vitro to a protein complex containing mLin 10 ( Mint1 / X11 ) and the NR2B subunit of the NMDA receptors ( NMDARs ) . ^^^ Here we present , for the first time , the dynamic properties of KIF 17 and provide evidence of its function in the transport of NR2B in living mammalian neurons . ^^^ Cellular knockdown or functional blockade of KIF 17 significantly impairs NR2B expression and its synaptic localization . ^^^ In contrast , upregulation of the expression level of NR2B , after treatment with the NMDAR antagonist D ( ) 2 amino 5 phosphonopentanoic acid , simultaneously increases the expression level of KIF 17 . ^^^ |
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| Interacting proteins: Q9P2E2 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This effect of 5 HT ( 1A ) receptors was blocked by agents that interfere with microtubule assembly , as well as by cellular knock down of the kinesin motor protein KIF 17 ( kinesin superfamily member 17 ) , which transports NR2B containing vesicles along microtubule in neuronal dendrites . ^^^ |
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| Interacting proteins: Q9P2E2 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The effect of microtubule depolymerizers on NMDAR currents was blocked by cellular knockdown of the kinesin motor protein KIF 17 , which transports NR2B containing vesicles along microtubule in neuronal dendrites . ^^^ |
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