| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This decrease was associated with significant variation in glutamate and DHPG stimulated phospholipase C activity . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors elicit epileptiform discharges in the hippocampus through PLCbeta 1 signaling . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate elicited the activation of PLD in cortical astrocytes but not in cortical neurons , whereas similar glutamate activation of phosphoinositide phospholipase C was found in both astrocytes and neurons . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Exposure of rat C 6 glioma cells to the beta adrenergic receptor agonist isoproterenol potentiates basal and metabotropic glutamate receptor stimulated phospholipase C activity in rat C 6 glioma cells . ^^^ After treatment of cells for 24 h with 10 microM isoproterenol , metabotropic glutamate receptors and phospholipase C activity were determined in C 6 plasma membranes . ^^^ These results show that metabotropic glutamate receptors and its effector system , phospholipase C , are affected by isoproterenol treatment , showing the existence of cross talk between these signal transduction pathways . . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These changes were associated with a significant reduction in the expression of subtype 5 metabotropic glutamate receptor protein ( 28 . 8 % ) and phospholipase C beta 1 ( 55 . 8 % ) in old striata , while receptor messenger ribonucleic acid expression was unchanged . ^^^ These results show that the signalling associated with subtype 5 metabotropic glutamate receptors undergoes significant age related changes and that a reduced expression of subtype 5 metabotropic glutamate receptors and , more importantly , phospholipase C beta 1 may account for the functional decline of subtype 5 metabotropic glutamate receptors . . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Abnormal metabotropic glutamate receptor expression and signaling in the cerebral cortex in diffuse Lewy body disease is associated with irregular alpha synuclein / phospholipase C ( PLCbeta 1 ) interactions . ^^^ This is associated with reduced expression levels of phospholipase C beta 1 ( PLCbeta 1 ) , the effector of group 1 mGluRs following protein G activation upon glutamate binding . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Metabotropic glutamate receptor / phospholipase C pathway : a vulnerable target to Creutzfeldt Jakob disease in the cerebral cortex . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The phospholipase C beta 1 ( PLC beta 1 ) signalling pathway , activated via metabotropic glutamate receptors ( mGluRs ) , is implicated in activity dependent development of the cerebral cortex , as both PLC beta 1 and mGluR 5 knockout mice exhibit disrupted barrel formation in somatosensory cortex . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Impaired metabotropic glutamate receptor / phospholipase C signaling pathway in the cerebral cortex in Alzheimer ' s disease and dementia with Lewy bodies correlates with stage of Alzheimer ' s disease related changes . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We determined the molecular basis of these phenotypes and show that PLC beta 1 is involved in signal transduction in the cerebral cortex and hippocampus by coupling predominantly to the muscarinic acetylcholine receptor , whereas PLC beta 4 works through the metabotropic glutamate receptor in the cerebellum , illustrating how PLC beta isoenzymes are used to generate different functions in the brain . . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors ( mGluR 1 ) regulate synaptic transmission through the stimulation of phospholipase Cbeta 1 ( PLCbeta 1 ) and then by the activation of protein kinase C ( PKC ) . ^^^ |
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| Interacting proteins: Q9NQ66 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here we report the effects of the analogous nonconservative substitution of glutamate for alanine 230 of the rPAFR ( rPAFR A230E ) on receptor mediated agonist binding and PI PLC activation following transient expression of the receptor cDNA . ^^^ |
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