| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Differential mechanisms of glutamate receptor regulation of SynGAP in cortical neurones . ^^^ |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In addition , cell biological experiments show that neuronal cultures from mutant mice have more synaptic AMPA receptor clusters , suggesting that SynGAP regulates glutamate receptor synaptic targeting . ^^^ These studies show that the regulation of synaptic Ras signaling by SynGAP is important for proper neuronal development and glutamate receptor trafficking and is critical for the induction of LTP . . ^^^ |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Proteins in the postsynaptic density , including synGAP , are part of a signaling complex attached to the cytoplasmic tail of the N methyl d aspartate type glutamate receptor . synGAP can be phosphorylated by a second prominent component of the complex , Ca ( 2+ ) / calmodulin dependent protein kinase 2 . ^^^ |
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| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| SynGAP is a brain specific ras GTPase activating protein that is an abundant component of the signaling complex associated with the NMDA type glutamate receptor . ^^^ |
|
| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| For example , the NR2B subunits of the NMDA receptor interact with postsynaptic density 95 ( PSD 95 ) , which in turn binds to synaptic ras GTPase activating protein ( SynGAP ) . ^^^ NR2B and SynGAP homozygote mice die within the first week of birth whereas PSD 95 homozygote mice survive to adulthood . ^^^ |
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| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Thus , SynGAP may play an important role in coupling N methyl D aspartate type glutamate receptor activation to signaling pathways downstream of Ras or Rap . ^^^ |
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| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synapses at P 2 contained substantial levels of NR 1 and NR2B and most GluR associated proteins , including SAP 102 , SynGAP , the chain of proteins from GluRs / SAP102 through GKAP / Shank / Homer and metabotropic glutamate receptors , and the adhesion factors , cadherin , catenin , neuroligin , and Nr CAM . ^^^ |
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| Interacting proteins: Q96PV0 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , the synaptic Ras GTPase activating protein ( GAP ) SynGAP is selectively associated with NR2B NMDARs in brain and is required for inhibition of NMDAR dependent ERK activation . ^^^ Preferential coupling of NR2B to SynGAP could explain the subtype specific function of NR2B NMDARs in inhibition of Ras ERK , removal of synaptic AMPARs , and weakening of synaptic transmission . . ^^^ |
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