| Interacting proteins: Q96NW7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| With the advent of powerful new microchemical tools and molecular genetic methods , three new classes of proteins have been identified in the PSD at glutamatergic synapses : the PSD 95 family , the NR2B subunit of the NMDA type glutamate receptor , and densin 180 . ^^^ |
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| Interacting proteins: Q96NW7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Densin 180 differs from the previously identified CaMKII binding protein NR2B in that binding does not strictly require CaMKII autophosphorylation . ^^^ Binding of densin 180 and NR2B to CaMKII is noncompetitive , indicating different interaction sites on CaMKII . ^^^ |
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| Interacting proteins: Q96NW7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Immunoblot analyses of cell homogenates indicated upregulation of NMDA receptor subunits ( NR 1 , NR2A , and NR2B ) , but downregulation of synaptic organizing proteins ( PSD 95 , densin 180 , and septin 6 homologue ) and a synapse enriched enzyme ( alphaCaMKII ) . ^^^ |
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| Interacting proteins: Q96NW7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Multivalent interactions of calcium / calmodulin dependent protein kinase 2 with the postsynaptic density proteins NR2B , densin 180 , and alpha actinin 2 . ^^^ We show that CaMKIIalpha is associated with the CaMKII binding proteins densin 180 , the N methyl D aspartate receptor NR2B subunit , and alpha actinin in postsynaptic density enriched rat brain fractions . ^^^ Similar amounts of Thr 286 autophosphorylated CaMKIIalpha holoenzyme [ P T 286 ] CaMKII bind to alpha actinin 2 as bind to NR2B ( residues 1260 1339 ) or to densin 180 ( residues 1247 1495 ) in glutathione agarose cosedimentation assays , even though the CaMKII binding domains share no amino acid sequence similarity . ^^^ Like NR2B , alpha actinin 2 binds to representative splice variants of each CaMKII gene ( alpha , beta , gamma , and delta ) , whereas densin 180 binds selectively to CaMKIIalpha . ^^^ In addition , C terminal truncated CaMKIIalpha monomers can interact with NR2B and alpha actinin 2 , but not with densin 180 . ^^^ |
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| Interacting proteins: Q96NW7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The NR2B subunit of N methyl d aspartate ( NMDA ) type glutamate receptor , densin 180 , and alpha actinin bind comparable , approximately stoichiometric amounts of Thr ( 286 ) autophosphorylated CaMKIIalpha , forming a ternary complex ( Robison , A . ^^^ |
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