| Interacting proteins: Q96A65 and Q13224 |
Pubmed |
SVM Score :0.0 |
| BACKGROUND : Sec 8 is highly expressed in mammalian nervous systems and has been proposed to play a role in several aspects of neural development and function , including neurite outgrowth , calcium dependent neurotransmitter secretion , trafficking of ionotropic glutamate receptors and regulation of neuronal microtubule assembly . ^^^ Synaptic electrophysiology showed no evidence that Sec 8 is required for basal neurotransmission , though glutamate receptor trafficking was mildly disrupted in sec 8 mutants . ^^^ Sec 8 is required in vivo for regulation of synaptic microtubule formation , and ( probably secondarily ) regulation of synaptic growth and glutamate receptor trafficking . ^^^ |
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| Interacting proteins: Q96A65 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We have found that two components of the exocyst complex , Sec 8 and Exo 70 , separately control synaptic targeting and insertion of AMPA type glutamate receptors . ^^^ |
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