Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
To elucidate the effects of the three compounds on other NAD utilizing enzymes , the inhibitory activities of purified benzamide adenine dinucleotide ( BAD ) , thiazole 4 carboxamide adenine dinucleotide ( TAD ) and selenazole 4 carboxamide adenine dinucleotide ( SAD ) were studied in commercially available purified preparations of lactate dehydrogenase , glutamate dehydrogenase and malate dehydrogenase . ^^^ Although BAD did not influence lactate and glutamate dehydrogenases , it selectively inhibited 50 % of malate dehydrogenase activity at a 3 . 2 microM concentration . ^^^ |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
Pretreatment of animals with FK 506 , a potent inhibitor of calcineurin activity , or MK 801 , an NMDA glutamate receptor antagonist , blocked BAD dephosphorylation and abolished activation of the caspase 3 apoptotic cascade . ^^^ These findings extend previous in vitro observations and are the first to implicate the involvement of glutamate mediated calcineurin activation and BAD dephosphorylation as upstream , premitochondrial signaling events leading to caspase 3 activation in traumatic spinal cord injury . . ^^^ |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
The bile acid tauroursodeoxycholic acid modulates phosphorylation and translocation of bad via phosphatidylinositol 3 kinase in glutamate induced apoptosis of rat cortical neurons . ^^^ In conclusion , TUDCA appears to modulate glutamate induced neuronal apoptosis , in part , by activating a PI3K dependent Bad signaling pathway . ^^^ |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
NA |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
NA |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
NA |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
NA |
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Interacting proteins: Q92934 and Q13224 |
Pubmed |
SVM Score :0.0 |
NA |
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