| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| No association was observed between SAP 102 and GluR 1 , a member of the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate class of glutamate receptors . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Recombinant proteins containing the carboxy terminal tail of NMDA receptor subunit NR2B interact with SAP 102 from rat brain homogenates . ^^^ All three PDZ domains in SAP 102 bind the cytoplasmic tail of NR2B in vitro . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Postsynaptic localization of N methyl D aspartate type glutamate receptors may be mediated by the synapse associated proteins ( SAPs ) SAP 90 , SAP 102 , and chapsyn 110 . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PSD 95 ( SAP 90 ) , SAP 102 and Chapsyn 110 ( PSD 93 ) are members of the membrane associated guanylate kinase family , and interact with N methyl D aspartate ( NMDA ) receptor NR2A ( GluRepsilon 1 ) and NR2B ( GluRepsilon 2 ) subunits and with Shaker type K+ channel subunits to cluster into a channel complex . ^^^ PSD 95 and SAP 102 mRNAs were prominently expressed at embryonic day 13 ( E 13 ) in the mantle zone of various brain regions , where NMDA receptor NR2B subunit mRNA is expressed at high levels . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| From Western blots of hippocampus and immunogold analysis of CA 1 synapses , the high expression of NR2B at P 2 coincides with the high level of SAP 102 at synapses , whereas the later expression of NR2A coincides with that of PSD 93 and PSD 95 . ^^^ To determine whether the changes in PSD 93 / 95 and SAP 102 reflect preferred associations with NR2A and NR2B , respectively , we measured co immunoprecipitation in the adult hippocampus . ^^^ These studies suggest that there is a preference for complexes of NR2A / PSD 93 / 95 and NR2B / SAP 102 . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We quantitatively defined the contributions of carboxyl terminal residues to binding selectivity of the prototypic interactions of the PDZ domains of postsynaptic density protein 95 ( PSD 95 ) and its homolog synapse associated protein 90 ( SAP 102 ) with the NR2b subunit of the N methyl d aspartate type glutamate receptor . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Each family of PSD proteins is selective for a given glutamate receptor subtype , the most well characterized being the NMDA receptor binding proteins PSD 93 , PSD 95 , NF L , and SAP 102 . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , we investigated dopamine glutamate interactions by measuring the expression of transcripts encoding the subunits for the ionotropic glutamate receptors ( NMDA , AMPA and kainate ) and five NMDAR associated intracellular proteins , PSD 93 , PSD 95 , SAP 102 , NF L and yotiao in the dopaminergic neurons in the substantia nigra pars compacta ( SNc ) of subjects with schizophrenia and a comparison group . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We review the potential roles in brain plasticity of two membrane associated guanylate kinases ( MAGUKs ) , SAP 102 and PSD 95 , which form a scaffold for the ion passing glutamate receptors at the postsynaptic density , and we consider the known functional significance of these molecules in subunit switching . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Ser 1480 disrupts the interaction of NR2B with the PDZ domains of PSD 95 and SAP 102 and decreases surface NR2B expression in neurons . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synapses at P 2 contained substantial levels of NR 1 and NR2B and most GluR associated proteins , including SAP 102 , SynGAP , the chain of proteins from GluRs / SAP102 through GKAP / Shank / Homer and metabotropic glutamate receptors , and the adhesion factors , cadherin , catenin , neuroligin , and Nr CAM . ^^^ Development was marked by substantial decreases in NR2B and SAP 102 and increases in NR2A , PSD 95 , AMPA receptors , and CaMKII . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These changes in spine density were accompanied by altered expression of proteins known to interact with PSD 95 , including NR2B and SAP 102 , suggesting that PSD 95 plays a role in regulating the expression and activation of proteins found within the NMDA receptor complex . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In the present study , we performed western blot analysis to determine whether protein levels of NMDA receptor subunits ( NR 1 , NR2A , NR2B ) and associated PSD proteins ( NF L , PSD 95 , SAP 102 ) are altered in schizophrenia . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements , i . e . , members of the membrane associated guanylate kinase ( MAGUK ) protein family postsynaptic density 95 , synapse associated protein 97 and synapse associated protein 102 . ^^^ |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q92796 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|