| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Dendritic and axonal targeting of type 5 metabotropic glutamate receptor is regulated by homer 1 proteins and neuronal excitation . ^^^ |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An N terminal sequence specific for a novel Homer 1 isoform controls trafficking of group 1 metabotropic glutamate receptor in mammalian cells . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Homer 1 mRNA in the rat suprachiasmatic nucleus is regulated differentially by the retinohypothalamic tract transmitters pituitary adenylate cyclase activating polypeptide and glutamate at time points where light phase shifts the endogenous rhythm . ^^^ The changes in Homer 1 gene expression after in vitro stimulation with PACAP and / or glutamate differed at early and late night . ^^^ Nanomolar PACAP induced Homer 1 gene expression at both early and late night while glutamate was only able to increase Homer 1 mRNA level at early night . ^^^ PACAP in micromolar concentration had no effect per se , but inhibited the glutamate induced Homer 1 response at early night , while at late night co administration of PACAP and glutamate mediated a slight induction of Homer 1 gene expression . ^^^ In conclusion , the RHT transmitters PACAP and glutamate could be responsible for the light induced expression of Homer 1 in the SCN , and Homer 1 seems to be differentially regulated by the two transmitters at early and late night . . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| There are three Homer genes ; the Homer 1 and 2 gene products control trafficking and calcium store related functions of metabotropic glutamate receptors ( e . g . mGluR1alpha ) . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In cultured hippocampal neurons , Homer family members Homer 1 , Cupidin / Homer 2 and Homer 3 showed similar glutamate induced declustering . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The postsynaptic scaffold proteins ProSAP1 / Shank2 and Homer 1 are associated with glutamate receptor complexes at rat retinal synapses . ^^^ With double labeling experiments and confocal microscopy , we analyzed the association of ProSAP1 / Shank2 with proteins specific for glutamatergic , glycinergic , and gamma aminobutyric acid ( GABA ) ergic synapses and with proteins known to be involved in the structural and functional organization of PSDs containing N methyl D aspartate receptors [ 95 kDa postsynaptic density protein ( PSD 95 ) ] , group 1 metabotropic glutamate receptors ( Homer 1 ) , and alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate ( AMPA ) receptors [ glutamate receptor interacting protein ( GRIP ) ] . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , we report that deletion of Homer 1 or Homer 2 in mice caused the same increase in sensitivity to cocaine induced locomotion , conditioned reward , and augmented extracellular glutamate in nucleus accumbens as that elicited by withdrawal from repeated cocaine administration . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , in Homer 1 KO mice , cocaine did not stimulate a rise in frontal cortex extracellular glutamate levels , suggesting hypofrontality . ^^^ These behavioral and neurochemical data derived from Homer 1 mutant mice are consistent with the recent association of schizophrenia with a single nucleotide polymorphism in the Homer 1 gene and suggest that the regulation of extracellular levels of glutamate within limbo corticostriatal structures by Homer 1 gene products may be involved in the pathogenesis of this neuropsychiatric disorder . . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The long form Homer 1 proteins , Homer1b / c , assemble group 1 metabotropic glutamate receptors ( mGluR1 / 5 ) in large macromolecular complexes with sources of calcium influx and release at synapses as well as with components of the NMDA receptor complex at the neuronal cell membrane . ^^^ Thus , glutamate receptor scaffolding proteins of the Homer 1 family critically regulate the functions of striatal medium spiny neurons in complex motor tasks and its modulation by psychomotor stimulant drugs . . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Homer1a overexpression did not influence PFC basal glutamate content but blunted the glutamate response to cocaine in wild type mice . ^^^ These data demonstrate active and distinct roles for Homer1a and Homer1c isoforms in the PFC in the mediation of behavior , in the maintenance of basal extracellular glutamate , and in the regulation of PFC glutamate release relevant to schizophrenia and stimulant abuse comorbidity . . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Homer1a strongly attenuates calcium mobilization as well as MAP kinase activation induced by glutamate receptors and reduces synaptic contacts on spinal cord neurons that process pain inputs . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Visual experience regulates metabotropic glutamate receptor mediated plasticity of AMPA receptor synaptic transmission by homer1a induction . ^^^ |
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| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PSD Zip45 / Homer1c , which contains an enabled / VASP homology 1 ( EVH 1 ) domain and leucine zipper motifs , is a postsynaptic density ( PSD ) scaffold protein that interacts with metabotropic glutamate receptors and the shank family . ^^^ |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q86YM7 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|