| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate ( GLUT ) had a powerful excitant action on nearly all the neurons tested , increasing the electrical activity of the spontaneously active neurons as well as initiating activity in quiescent ARC neurons . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Microinjection of 0 . 3 microliters ( 150 mmol ) sodium glutamate ( Glu ) into the nucleus arcuatus ( ARC ) elicited a significant depressor effect in rats with chronic stress induced hypertension . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Microinjection of neuropeptide Y ( NPY ) into the nucleus tractus solitarius ( NTS ) induces an initial and reversible fall in arterial pressure ( AP ) and heart rate ( HR ) , along with a delayed and long lasting blockade of cardiovascular responses to L glutamate ( L Glu ) injected into the same site and an inhibition of the baroreflex arc . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The acute hypotensive , bradycardic response to glycine was followed by a period during which glycine essentially eliminated the cardiovascular responses to the microinjection into the NTS of glutamate , an amino acid reputed to be a transmitter in the baroreceptor reflex arc . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The data may suggest that glutamate is not a neurotransmitter in the baroreflex arc or that only certain glutamate receptors are integral to the baroreflex in the nucleus tractus solitarius . . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Resting activity and responses of ARC neurons to six anterior pituitary hormones , or ( as a positive control ) cholecystokinin octapeptide sulfate ( CCK 8S ) , and a battery of four neurotransmitters including norepinephrine , serotonin , dopamine , and glutamate were recorded . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Serum samples from persons with antibodies against the AIDS associated human immunodeficiency virus ( HIV / LAV / HTLV 3 ) including persons without overt symptoms , patients with lymphadenopathy syndrome ( LAS ) and patients with AIDS or AIDS related complex ( ARC ) contain on the average significantly elevated concentrations of arginine and glutamate . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| As GnRH is synthesized in various hypothalamic nuclei , including the arcuate nucleas ( ARC ) , we investigated the effects of monosodium glutamate ( MSG ) induced lesions of the ARC in the rat . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This study was performed to determine the effects of monosodium glutamate ( MSG ) induced lesions of the hypothalamic arcuate nucleus ( ARC ) on glucose tolerance and insulin and glucagon secretion in male golden hamsters . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Therefore the cellular composition of the ARC was studied in normal and monosodium glutamate ( MSG ) treated female rats at 22 , 35 , 55 days after birth and in mature ones . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A subgroup of young adult females had ARC lesions induced by monosodium glutamate at neonatal day 8 . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The glutamate that was present in the rods and cones occupied a crescentic arc corresponding to the location of glycogen rich paraboloids . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Experiments were done in urethane anesthetized rats to investigate the effect of glutamate ( Glu ) stimulation of arcuate nucleus of the hypothalamus ( Arc ) on the discharge rate of subfornical organ ( SFO ) neurons during changes in plasma sodium concentration and angiotensin 2 ( ANG 2 ) levels . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The effect of sodium glutamate ( Glu ) on plasma sialic acid ( SA ) level was studied by means of microinjection into the nucleus arcuatus ( ARC ) and ultraviolet spectrophotometry . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate may be a key transmitter in the emetic reflex arc . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Experiments were done in urethane anesthetized rats to investigate the effect of electrical and glutamate stimulation of arcuate nucleus ( Arc ) on the discharge rate of subfornical organ ( SFO ) neurons that responded to either plasma hypernatremia or angiotensin 2 ( ANG 2 ) . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In the present experiments using whole cell current and voltage clamp recording of neurons from cultures and slices of the ARC , we demonstrate for the first time that some of the neurons in the ARC secrete glutamate as their transmitter . 3 . ^^^ Using microdrop stimulation of presynaptic neurons in ARC slices , we found that local axons from these glutamatergic neurons make local synaptic contact with other neurons in the ARC and that all evoked excitatory postsynaptic potentials could be blocked by the selective ionotropic glutamate receptor antagonists 6 cyano 7 nitroquinoxaline 2 , 3 dione ( CNQX ; 10 microM ) and D , L 2 amino 5 phosphonovalerate ( AP 5 ; 100 microM ) . ^^^ In ARC cultures , postsynaptic potentials , both excitatory and inhibitory , were virtually eliminated by the glutamate receptor antagonists AP 5 and CNQX , underlining the functional importance of glutamate within this part of the neuroendocrine brain . 5 . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| None of the numerous neuroactive chemicals found in the NTS had met strict criteria as a neurotransmitter in the baroreflex arc until data suggested that the excitatory amino acid L glutamate ( GLU ) might be released from baroreceptor afferent terminals in the NTS . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The expression of metabotropic glutamate receptor ( mGluR ) mRNA ( mGluR 1 8 ) was studied in the suprachiasmatic ( SCN ) and arcuate ( ARC ) nuclei . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We have examined this ability of the medial basal hypothalamus ( MBH ) to recover from an excitotoxic insult using the immediate early gene c fos as a developmental marker of ARC response to glutamate receptor stimulation with N methyl D aspartate ( NMDA ) . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To evaluate the contribution of the arcuate nucleus ( Arc ) to this innervation , the effect of Arc ablation by neonatal monosodium glutamate ( MSG ) treatment on the density of NPY fibers contacting TRH neurons in the PVN was investigated . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To investigate the mechanism of Glu induced neuronal loss , we administered graded doses of the sodium salt of glutamate ( MSG ) to postnatal mice , measured their plasma Glu concentrations , and performed microscopic analyses of the ARC ME region 5 h after treatment . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The discharge patterns of the neurons may be dependent on many factors , including input from the different barosensitive receptor subtypes , the contribution of different ionotropic glutamate receptors [ NMDA ( N methyl D aspartate ) versus nonNMDA receptors ] in transmission of the input , effects of different neuropeptide neurotransmitters / neuromodulators on afferent transmission , or the order of the neuron within the barosensitive reflex arc . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| METHODS : Monosodium glutamate ( MSG ) 4 mg / g body weight was given subcutaneously to neonatal rats at 2 , 4 , 6 , 8 and 10th day after born to destroy the ARC , and Zuogui pill or Yougui pill ( 5 g / kg daily ) was given respectively by gastrogavage when the model rats entered adulthood . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined whether ghrelin could stimulate GH secretion and feeding in chronic GHRH , neuropeptide Y , and agouti related protein deficient rats that were neonatally treated with monosodium glutamate ( MSG ) , which destroys the neurons in the hypothalamic arcuate nucleus ( ARC ) . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In the present study , we used the neurotoxins monosodium glutamate ( MSG ) or goldthioglucose ( GTG ) to produce a selective ARC lesion and to assess its effects on the locomotion observed after ethanol administration . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| By combining patch clamp and RT multiplex PCR analysis of individual neurons in mouse brain slices , we show that an electrophysiologically distinct subset of ARC neurons coexpress orexin receptors and glutamate decarboxylase 67 and are excited by orexin . ^^^ |
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| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| At the age when these animals developed cognitive dysfunction , they had reduced mRNA expression of several genes essential for long term potentiation and memory formation ( Arc , Zif 268 , NR2B , GluR 1 , Homer 1a , Nur77 / TR3 ) . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Neonatal lesioning of the hypothalamic arcuate nuclei ( ARC ) with monosodium glutamate markedly reduced the number of NPY fibers in the preoptic area as well as the frequency of their contacts with perikarya and proximal dendrites of GnRH neurons . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate receptor activation is involved in 5 HT 2 agonist induced Arc gene expression in the rat cortex . ^^^ These results suggest that , as with c fos expression , ionotropic glutamate receptors ( AMPA and NMDA ) are involved in 5 HT2A receptor induced Arc expression . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| GABA immunoreactive hair cells follow the arc of the striola , and most GABA labeled receptor cells coexpress glutamate . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Arc protein has been demonstrated to regulate AMPA type glutamate receptor trafficking by recruiting endosomal pathways , suggesting a direct role in synaptic plasticity . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A model is proposed in which BDNF signaling at glutamate synapses drives the translation of newly transported ( Arc ) and locally stored ( i . e . , alphaCaMKII ) mRNA in dendrites . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The phosphorylation states of NR2B and ERK1 / 2 were reduced in the dentate gyrus of hAPP mice , suggesting attenuated activity in NMDA dependent signaling pathways that regulate synaptic plasticity as well as Arc expression . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The Arc also contained 5 HT ( 1A ) , kainate ( GluR 5 ) , and 5 HT ( 2A ) receptors , which localized predominantly to 5 HT neurons , glutamate neurons and astrocytes , respectively . ^^^ These observations suggest that important functional interactions exist between 5 HT , glutamate , and astrocytes in the Arc . ^^^ |
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| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| While Arc synthesis is critical for local actin polymerization and stable LTP formation , several of the co upregulated genes have known functions in excitatory synaptogenesis , axon guidance and glutamate receptor clustering . ^^^ |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q7LC44 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|