| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We found that the tyrosine kinase related adhesion focal tyrosine kinase ( RAFTK ) is tyrosine phosphorylated in response to glutamate in a time and dose dependent manner . ^^^ RAFTK tyrosine phosphorylation was mediated primarily by class I / II metabotropic glutamate receptors and depends on protein kinase C ( PKC ) activation . ^^^ Like RAFTK phosphorylation , ERK1 / 2 activation is PTX sensitive and can be attenuated by the depletion of intracellular Ca2+ and by PKC inhibition , suggesting that RAFTK might mediate the glutamate dependent activation of ERK1 / 2 . ^^^ Glutamate stimulated DNA synthesis is PTX sensitive and can be inhibited by the MAP kinase kinase inhibitor PD 98059 , suggesting that in primary astrocytes , glutamate might signal via RAFTK and MAP kinase to promote DNA synthesis and cell proliferation . . ^^^ Glutamate stimulated activation of DNA synthesis via mitogen activated protein kinase in primary astrocytes : involvement of protein kinase C and related adhesion focal tyrosine kinase . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A 1 h incubation of neuronal cultures with tetrodotoxin ( TTX ) , the PI3K inhibitor wortmannin , the NMDA receptor antagonist MK 801 or removal of extracellular calcium significantly reduced basal levels of phospho ( Ser 473 ) PKB , indicating that activity dependent glutamate release maintains PKB activation through an NMDA receptor PI3K pathway . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Inhibiting Src family tyrosine kinase activity blocks glutamate signalling to ERK1 / 2 and Akt / PKB but not JNK in cultured striatal neurones . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In EAAT 3 expressing Xenopus oocytes , glutamate induced current was stimulated by coexpression of wild type SGK 1 , constitutively active ( S422D ) SGK 1 , and constitutively active ( T308D , S473D ) PKB , but not by inactive ( K127N ) SGK 1 . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the EAAT 4 glutamate transporter by SGK protein kinase isoforms and PKB . ^^^ The kinase activates glutamate induced current ( 1 ( GLU ) ) in Xenopus oocytes heterologously expressing EAAT 4 , an effect mimicked by its isoforms SGK 2 , 3 and PKB . 1 ( GLU ) was decreased by the ubiquitin ligase Nedd 4 2 , an effect partially but not completely reversed by additional coexpression of the SGK kinase isoforms or PKB . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Expression studies in Xenopus oocytes demonstrated that glutamate induced inward current ( IGLU ) was stimulated by co expression of SGK 1 , SGK 2 , SGK 3 or PKB . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Thus , whereas application of glutamate to hippocampal slices from control mice increased fyn protein tyrosine kinase ( PTK ) activity more than 2 . 5 fold , these changes were significantly impaired in LP BM 5 MuLV infected mice . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An important subtype of glutamate receptor , the NMDA receptor , is shown to be regulated by insulin via protein tyrosine kinase ( PTK ) . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , we show that brain derived neurotrophic factor ( BDNF ) and platelet derived growth factor enhance expression of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) type glutamate receptor 1 and 2 / 3 proteins in rodent neocortical neurons via the Src family PTK ( s ) . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Selective inhibition of either metabotropic glutamate receptors ( mGluRs ) , protein kinase C ( PKC ) or tyrosine protein kinase ( PTK ) blocked depression at both sites equally effectively . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate induced apoptotic like death ( determined by DAPI staining ) was largely prevented by inhibition of NMDA R , PKC , CaM kinase 2 , PTK and MEK1 / MEK2 ( ERK1 / ERK2 kinase ) , respectively . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Protein tyrosine phosphatase ( PTP ) inhibitor vanadate and protein tyrosine kinase ( PTK ) inhibitor genestein resulted in the increase and the decrease of the tyrosine phosphorylation of NR2B , respectively . ^^^ CONCLUSION : The increase of the tyrosine phosphorylation of NR2B induced by I / R has relation to NR and L type VGCC ; PTK and PTP participate in the regulation of the tyrosine phosphorylation of NR2B during I / R . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The selective src PTK inhibitor PP 1 ( 10 microm intracellularly ) potentiated submaximal mGluR 1 currents evoked by low L glutamate concentrations but had no effect on maximal responses ( 80 or 160 microm L glutamate ) . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The ventilatory responses of peripheral chemoreflex following 0 . 1 microl microinjection within the NTS of either PTK inhibitor genistein ( 10 mol / L ) , AMPA glutamate receptor inhibitor CNQX ( 10 mol / L ) , or inactive PTK inhibitor daidzein ( 10 mol / L ) were recorded . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Following ischemia , tyrosine phosphorylation of NR2A and NR2B and activated Src family kinases ( SFKs ) and Pyk 2 were increased in post synaptic densities ( PSDs ) . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A dominant negative Pyk 2 mutant significantly reduced insulin potentiation when co expressed with NR2B containing receptors , suggesting that Pyk 2 and downstream Src family tyrosine kinases are involved , along with PKCs , in insulin potentiation of NR2B . ^^^ |
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| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Transient forebrain ischemia effects interaction of Src , FAK , and PYK 2 with the NR2B subunit of N methyl D aspartate receptor in gerbil hippocampus . ^^^ Two different models of brain ischemia were used to examine the evoked changes in the tyrosine phosphorylation of NMDA receptor subunits 2A and 2B ( NR2A and NR2B ) , as well as their interactions with non receptor tyrosine kinases ( NRTKs : FAK , PYK 2 Src ) , and PSD 95 protein . ^^^ Concomitantly , an increased association of NR2B with FAK , PYK 2 , Src and PSD 95 has been observed . ^^^ |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q14289 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|