Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Three cDNA clones , mGluR 2 , mGluR 3 , and mGluR 4 , were isolated from a rat brain cDNA library by cross hybridization with the cDNA for a metabotropic glutamate receptor ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Signal transduction and pharmacological characteristics of a metabotropic glutamate receptor , mGluR 1 , in transfected CHO cells . ^^^ The signal transduction and pharmacological properties of a metabotropic glutamate receptor , mGluR 1 , were studied in CHO cells permanently expressing the cloned receptor . mGluR 1 stimulated phosphatidylinositol ( PI ) hydrolysis in the potency rank order of quisqualate greater than L glutamate greater than or equal to ibotenate greater than L homocysteine sulfinate greater than or equal to trans ACPD . ^^^ DL AP 3 and L AP 4 , the effective antagonists reported for glutamate stimulated PI hydrolysis in brain slices , showed no appreciable effects on mGluR 1 , suggesting the existence of an additional subtype of this receptor family . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Depolarization and agonist regulated expression of neuronal metabotropic glutamate receptor 1 ( mGluR 1 ) . ^^^ In established 8 12 day old primary cultures of differentiated rat cerebellar granule neurons the level of metabotropic glutamate receptor 1 ( mGluR 1 ) mRNA and the sensitivity of cultures to the agonist stimulated inositol phosphate ( IP ) formation was reversibly modified by changing the depolarizing properties of the medium , i . e . the medium KCl concentration . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This receptor also resembles mGluR 1 in its agonist selectivity and antagonist responses ; the potency rank order of agonists for mGluR 5 was determined to be quisqualate greater than L glutamate greater than or equal to ibotenate greater than trans 1 aminocyclopentane 1 , 3 dicarboxylate . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In rat brain , the cellular localization of a phosphoinositide linked metabotropic glutamate receptor ( mGluR 1 alpha ) was demonstrated using antibodies that recognize the C terminus of the receptor . mGluR 1 alpha , a 142 kd protein , is enriched within the olfactory bulb , stratum oriens of CA 1 and polymorph layer of dentate gyrus in hippocampus , globus pallidus , thalamus , substantia nigra , superior colliculus , and cerebellum . ^^^ The postsynaptic distribution of mGluR 1 alpha is consistent with postulated physiological roles of this subtype of glutamate receptor . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The agonist potencies and selectivities of these compounds for metabotropic glutamate receptors ( mGluRs ) were studied by examining their effects on the signal transduction of representative mGluR 1 , mGluR 2 and mGluR 4 subtypes in Chinese hamster ovary cells expressing the individual cloned receptors . 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We examined the ontogenesis of a subtype of metabotropic glutamate receptors , termed mGluR 1 , which is linked to phosphoinositide metabolism , in various regions of rat brain during neonatal development . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
An amino acid , 3 , 5 dihydroxyphenylglycine ( DHPG ) induced current responses in Xenopus oocytes expressing a metabotropic glutamate receptor clone mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Distribution of the mRNA for a metabotropic glutamate receptor ( mGluR 1 ) in the central nervous system : an in situ hybridization study in adult and developing rat . ^^^ Distribution of the mRNA for a metabotropic glutamate receptor ( mGluR 1 ) , which is linked to phosphoinositide ( PI ) hydrolysis , was investigated in adult and developing rat central nervous system ( CNS ) by in situ hybridization . ^^^ These results show prominent expression of mGluR 1 in the major targets of putative glutamatergic pathways and unique distribution pattern of mGluR 1 distinct from those reported for ionotropic subtypes of glutamate receptors , suggesting specific roles of mGluR 1 in the glutamatergic system . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The distribution of glutamate receptor subunit / subtypes in the vertebrate retina was investigated by immunocytochemistry using anti peptide antibodies against AMPA ( GluR 1 4 ) , kainate ( GluR6 / 7 ) and metabotropic ( mGluR 1 alpha ) receptors . ^^^ This property and our present observation together suggest that the glutamate receptors previously studied electrophysiologically by others in horizontal cells may contain GluR 6 . mGluR 1 alpha is found mostly in the inner plexiform layer ; its localization partially overlaps with that of the inositol trisphosphate receptor in the retina . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate evoked pertussis toxin sensitive currents in Xenopus oocytes expressing metabotropic glutamate receptor subtype 1 ( mGluR 1 ) and exogenous Gi 1 alpha . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptors ( mGluRs ) form a family of G protein coupled receptors which consists of at least seven members termed mGluR 1 mGluR7 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Clonal BHK cells permanently transfected with the metabotropic glutamate receptor 1 alpha ( mGluR 1 alpha ) , which is coupled to phospholipase C , were used to study the phosphorylation state of the receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The affinities of the title compounds for displacement of receptor binding to ionotropic and metabotropic ( mGluR 1 alpha ) glutamate receptors were also determined . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunohistochemical study of two phosphoinositide linked metabotropic glutamate receptors ( mGluR 1 alpha and mGluR 5 ) in the cat visual cortex before , during , and after the peak of the critical period for eye specific connections . ^^^ The distribution of two phosphoinositide linked metabotropic glutamate receptors ( mGluR 1 alpha and mGluR 5 ) was studied immunohistochemically in area 17 before , during and after the peak of use dependent modification of eye specific connections . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Using in situ hybridization histochemistry , we examined the expression of messenger RNAs encoding the mGluR 1 and mGluR 5 subtypes of metabotropic glutamate receptors in the suprachiasmatic nucleus of the adult rat and during postnatal development . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The immunocytochemical localization of the recently cloned metabotropic glutamate receptor 1 alpha ( mGluR 1 alpha ) was demonstrated with a C terminus specific antibody in rat cerebellar cortex . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
By immunocytochemistry , the metabotropic glutamate receptor mGluR 1 alpha was detectable only in a subpopulation of GABAergic interneurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A pharmacological characterization of the mGluR 1 alpha subtype of the metabotropic glutamate receptor expressed in a cloned baby hamster kidney cell line . ^^^ The pharmacological specificity of the mGluR 1 alpha subtype of the metabotropic glutamate receptor ( mGluR ) was examined in a cloned baby hamster kidney cell line ( BHK ts 13 ) measuring [ 3H ] glutamate binding and inositol phosphate ( PI ) hydrolysis . ^^^ Saturation binding studies with [ 3H ] glutamate on membranes prepared from BHK ts 13 cells expressing the mGluR 1 alpha subtype showed that glutamate binds to a single affinity state of this receptor with a limited capacity ( Kd = 296 nM , Bmax = 0 . 8 pmol / mg protein ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Molecular , functional , and pharmacological characterization of the metabotropic glutamate receptor type 5 splice variants : comparison with mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To determine the distributions of glutamate receptors throughout the macaque hypothalamus , we utilized highly specific antipeptide antibodies to visualize alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate receptor subunits ( GluR 1 , GluR 2 and GluR 3 [ designated as GluR2 / 3 ] , and GluR 4 ) ; kainate receptor subunits ( GluR 6 and GluR 7 , [ designated as GluR6 / 7 ] ) , and a metabotropic receptor ( mGluR 1 alpha ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The structure and post translational processing of the metabotropic glutamate receptor 1 alpha ( mGluR 1 alpha ) was analysed by in vitro cell free translation , protease protection and deglycosylation . ^^^ The data presented here on mGluR 1 alpha indicates the potential of in vitro translation and protease protection in the study of the molecular structure and processing of glutamate receptors . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor mGluR 1 distribution and ultrastructural localization in hypothalamus . ^^^ The metabotropic glutamate receptor mGluR 1 is a G protein coupled glutamate receptor whose activation induces phosphotidylinositol hydrolysis and increases diacylglycerol and cytoplasmic calcium . ^^^ By using affinity purified antisera against a partial amino acid sequence of mGluR 1 alpha , deduced from the nucleotide sequence of the cloned gene , the heterogeneous expression of this glutamate receptor was studied immunocytochemically with light and electron microscopy in the rat hypothalamus . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Differential cellular localization of three splice variants of the mGluR 1 metabotropic glutamate receptor in rat cerebellum . ^^^ Antibodies were raised against C terminal peptides of the splice variants a , b and c of the rat mGluR 1 metabotropic glutamate receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor mGluR 4 , but not mGluR 1 alpha , is palmitoylated when expressed in BHK cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The antibody recognizes both delta 1 and delta 2 but not AMPA , kainate , NMDA , and mGluR 1 alpha glutamate receptor subunits based on Western blot analysis of transfected HEK 293 cells . ^^^ Based on results of these studies , AMPA , kainate , NMDA , and mGluR 1 alpha subunits do not coassemble with delta subunits , and 3H glutamate , 3H AMPA and 3H kainate do not bind to the delta receptor complex . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Antibodies inactivating mGluR 1 metabotropic glutamate receptor block long term depression in cultured Purkinje cells . ^^^ Antibodies were raised against two distinct extracellular sequences of the rat mGluR 1 metabotropic glutamate receptor expressed as bacterial fusion proteins . ^^^ Both antibodies specifically reacted with mGluR 1 in the rat cerebellum and inhibited the mGluR 1 activity as assessed by the analysis of glutamate stimulated inositol phosphate formation in CHO cells expressing mGluR 1 . ^^^ The mGluR 1 antibodies completely blocked the depression of glutamate induced current . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A subpopulation of cerebellar granule neurons in culture expresses a functional mGluR 1 metabotropic glutamate receptor : effect of depolarizing growing conditions . ^^^ Homogeneous neuronal cultures of cerebellar granule neurons express different levels of metabotropic glutamate receptor mGluR 1 mRNA depending on the concentration of KCl present during the culture period . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We used in situ hybridization to examine the effect of removal of the glutamatergic input to the striatum by unilateral frontal cortical ablation on the expression of genes encoding subunits from three families of glutamate receptors : N methyl D aspartate receptors ( NMDAR 1 , NMDAR2A , and NMDAR2B ) ; alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate ( AMPA ) receptors ( GluR 1 4 , flip and flop splice variants ) ; and metabotropic receptors ( mGluR 1 5 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
An ionotropic glutamate receptor of the kainate subtype ( GluR 6 ) and a G protein coupled metabotropic glutamate receptor ( mGluR 1 alpha ) were expressed and studied in two insect cell lines : sf 9 cells from Spodoptera frugiperda and MG 1 cells from Trichoplusia ni . ^^^ Glutamate activation of mGluR 1 alpha in MG 1 and sf 9 infected cells caused rapid , transient increases in intracellular calcium levels . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We generated a novel strain of mutant mouse with a deletion in the gene encoding metabotropic glutamate receptor 1 ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To characterize G proteins which mediate the signal transduction from ligand stimulated receptor to phospholipase C ( PLC ) , we injected antisense DNAs complementary to Xenopus G ( o ) alpha or Gi l alpha to suppress these endogenous G proteins , together with the mRNAs encoding metabotropic glutamate receptor 1 ( mGluR 1 ) , 5 ( mGluR 5 ) or with M 1 type muscarinic receptor into oocytes . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Stereoselective antagonism of the metabotropic glutamate receptor mGluR 1 alpha by alpha methyl 4 carboxyphenylglycine . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( mGluR 1 ) is a member of a large family of G protein coupled glutamate receptors , the physiological functions of which are largely unknown . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The messenger RNAs encoding five metabotropic glutamate receptor subtypes named mGluR 1 5 had distinct regional and temporal expression profiles . mGluR 1 , mGluR 2 and mGluR 4 messenger RNA expression was low at birth and increased during postnatal development . ^^^ A striking correspondence between the temporal pattern of expression of specific metabotropic glutamate receptor transcripts and metabotropic binding sites was observed in the reticular nucleus of the thalamus ( mGluR 3 ; metabotropic type 2 binding sites ) and cerebellum ( mGluR 1 ; metabotropic type 1 binding sites ) suggesting early translation of these metabotropic glutamate receptor messenger RNAs into receptor proteins . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor subtype 1 ( mGluR 1 ) , when expressed in Xenopus oocytes , activates phosphoinositide specific phospholipase C ( PLC ) in a G protein dependent manner . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
However , the vestibular nuclei were not labelled by the glutamate metabotropic oligonucleotide antisense probe ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptors mediate their intracellular response by coupling to G proteins and may be divided into three subfamilies : mGluR 1 and mGluR 5 , which stimulate phosphatidylinositol hydrolysis ; mGluR 2 and mGluR 3 , which are negatively coupled to cyclic AMP formation ; and mGluR 4 and mGluR 6 , which also inhibit forskolin stimulated cyclic AMP formation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Amplification of complementary DNA by the polymerase chain reaction and anti peptide antibodies were used to characterize the expression of two alternatively spliced forms of a metabotropic glutamate receptor ( mGluR 1 alpha and mGluR 1 beta ) in the central nervous system of the rat . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mRNA for the metabotropic glutamate subunit mGluR 1 was only lightly expressed in the SCN . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor ( type 1 ; mGluR 1 ) is expressed predominantly in the hippocampus and the cerebellum . ^^^ Levels of mGluR 1 mRNA were decreased to less than half by high potassium stimulation and by glutamate and quisqualate . ^^^ Although these glutamate receptor agonists tested are also known to cause neuronal cell death in culture , the effect of cell death can not explain the observed reduction in mGluR 1 mRNA because of the following reasons : ( a ) antagonists of N methyl D aspartate and non N methyl D aspartate receptors inhibited cell death , but not the reduction of the level of mGluR 1 mRNA ; ( b ) mGluR 1 mRNA returned to its initial level 48 h after the agonist application ; and ( c ) the mRNA level of one of the alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionate / kainate receptors ( GluR 1 ) was not altered by these conditions . ^^^ Therefore , we conclude that the glutamate or quisqualate stimulation can specifically inhibit the expression of mGluR 1 mRNA . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptors consist of at least six different subtypes termed mGluR 1 mGluR6 . ^^^ They belong to the family of G protein coupled receptors and commonly possess an unusually large extracellular domain preceding the seven transmembrane segments . mGluR 1 and mGluR 2 show similar affinities for L glutamate but distinct patterns in their responsiveness to quisqualate and trans 1 amino 1 , 3 cyclopentane dicarboxylate ( tACPD ) . ^^^ To assign structural determinants for the different agonist selectivities , we constructed a series of chimeric receptors at the extracellular domains of mGluR 1 and mGluR 2 and determined their agonist selectivities by measuring their electrophysiological responses to L glutamate , quisqualate , and tACPD in Xenopus oocytes . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor ( mGluR 1 alpha ) is concentrated at perisynaptic membrane of neuronal subpopulations as detected by immunogold reaction . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
L SOP or D SOP ( 3 mM ) did not inhibit PI hydrolysis as stimulated by 10 microM glutamate in BHK cells expressing mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Despite the cloning of several metabotropic glutamate receptors ( mGluR 1 6 ) , the activity and localization of the cloned mGluRs do not account for the action of L 2 amino 4 phosphonobutyric acid ( L AP 4 ) on mitral / tufted cells in the rat olfactory bulb . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Among the phenylglycine derivatives with no mGluR 1 agonist activity , ( S ) 4C3HPG , ( S ) 3C4HPG , ( S ) 4CPG , and ( + ) alpha M4CPG effectively antagonized the action of L glutamate on mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Several cDNAs coding for metabotropic glutamate receptors ( mGluR 1 7 ) have now been isolated . mGluR 1 and 5 are positively coupled to phospholipase C , whereas mGluR 2 , 3 , 4 , 6 , and 7 are negatively coupled to adenylyl cyclase ( AC ) when they are expressed in Chinese hamster ovary or baby hamster kidney cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Developmental regulation of the hypothalamic metabotropic glutamate receptor mGluR 1 . ^^^ The expression of the metabotropic glutamate receptor mGluR 1 was studied with Northern and Western blot analysis , with immunocytochemistry , and with Ca2+ digital imaging in the developing rat hypothalamus . mGluR 1 is coupled to a G protein and activation by glutamate and related agonists leads to intracellular phosphotidylinositol hydrolysis and Ca2+ mobilization . mGluR 1 RNA could be detected in embryonic hypothalamus , and by the day of birth and prior to the primary period of synaptogenesis , both mGluR 1 RNA and protein were strongly expressed . ^^^ Together these data suggest a complex regulation of mGluR 1 during development , with sufficient expression of functional receptors in the developing hypothalamus to modulate morphogenesis and synaptogenesis , and later to play a role in transduction of glutamate signals in the adult . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Expression of the metabotropic glutamate receptor mGluR 1 alpha and the ionotropic glutamate receptor GluR 1 in the brain during the postnatal development of normal mouse and in the cerebellum from mutant mice . ^^^ Expression of the metabotropic glutamate receptor type 1 alpha ( mGluR 1 alpha ) and the non N methyl D aspartate ( NMDA ) ionotropic glutamate receptor type 1 ( GluR 1 ) in mouse brain was investigated using the antibodies raised against the synthetic peptides corresponding to their C terminal amino acid sequences . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Two new complementary DNAs overlapping cDNA clones that encode the G protein coupled metabotropic glutamate receptor mGluR 1 from rat brain have been isolated and sequenced in their entirety . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Functional evidence for a L AP 3 sensitive metabotropic receptor different from glutamate metabotropic receptor mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this culture the new rigid glutamate analogue , ( + / ) trans azetidine 2 , 4 dicarboxylic acid ( t ADA ) and the known mGluR agonist 1S , 3R aminocyclopentane 1 , 3 dicarboxylic acid ( 1S , 3R ACPD ) stimulated IP formation in line with the depolarization modified expression of mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Differential localization of phosphoinositide linked metabotropic glutamate receptor ( mGluR 1 ) and the inositol 1 , 4 , 5 trisphosphate receptor in rat brain . ^^^ The type 1 metabotropic glutamate receptor ( mGluR 1 ) is through to act via the phosphoinositide ( PI ) system with the associated formation of inositol 1 , 4 , 5 trisphosphate ( IP 3 ) and Ca2+ release . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A comparison of the pharmacological and physiological properties of the metabotropic glutamate 1 alpha and 1 beta receptors ( mGluR 1 alpha and mGluR 1 beta ) expressed in baby hamster kidney ( BHK 570 ) cells was performed . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The pharmacology of ( DL ) 4 carboxy 3 hydroxyphenylglycine was examined in baby hamster kidney cells which stably express the type 1 metabotropic glutamate receptor ( mGluR 1 alpha ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Of the six metabotropic glutamate receptors ( mGluRs ) only mGluR 1 and mGluR 5 , which possess a large carboxyl terminal domain , are positively linked to phosphoinositide ( PI ) hydrolysis . ^^^ Glutamate activation of PI hydrolysis was reduced by pertussis toxin when mediated via mGluR 1 alpha , while mGluR1T required the presence of extracellular Ca2+ . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Furthermore , 2R , 4R APDC had no measurable ionotropic glutamate receptor affinity in rat hippocampus , as indicated by lack of effects on basal and glutamate agonist evoked [ 3H ] norepinephrine release . 2R , 4R APDC also inhibited forskolin stimulated cAMP formation in human mGluR 2 expressing cells with about three fold greater potency than 1S , 3R ACPD , but unlike 1S , 3R ACPD , showed no appreciable activation of phosphoinostide hydrolysis in human mGluR 1 alpha expressing cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The antagonist effects of the 4 carboxyphenylglycines : ( S ) 4 carboxy 3hydroxyphenylglycine ( 4C3HPG ) , ( S ) 4 carboxyphenylglycine ( 4CPG ) and ( + ) alpha methyl 4 carboxyphenylglycine ( M4CPG ) were compared on functional responses of human metabotropic glutamate receptor ( mGluR ) subtypes mGluR 1 alpha and mGluR5a . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the adult and developing ( postnatal day 10 ) brain , immunoreactive neurons were found in the suprachiasmatic nucleus , preoptic area , lateral hypothalamus , and mammillary region , areas where the related metabotropic glutamate receptor mGluR 1 is also found . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The G protein coupled metabotropic glutamate receptor mGluR 1 alpha and the ionotropic glutamate receptor GluR 6 were examined for posttranslational palmitoylation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The C terminal domain of the mGluR 1 metabotropic glutamate receptor affects sensitivity to agonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Uneffective at mGluR 1 , 35 is a weak mGluR 4 agonist ( EC 50 = 156 microM ) and has no effect on either ionotropic receptors or glutamate transport systems , thus demonstrating to be a novel selective mGluR 2 antagonist with a 6 fold increase in potency over previously reported antagonists . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate stimulates phosphatidyl inositol hydrolysis and mobilizes intracellular calcium through the mediation of metabotropic glutamate receptors ( mGluRs ) , in particular the `` Group 1 ' ' receptors mGluRs , mGluR 1 , and mGluR 5 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We investigated the agonist and antagonist activities of 22 new phenylglycine and phenylalanine derivatives for metabotropic glutamate receptors ( mGluRs ) by examining their effects on the signal transduction of mGluR 1 , mGluR 2 and mGluR 6 subtypes expressed in Chinese hamster ovary cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The current through homomeric NMDAR 1 expressed in Xenopus oocytes was increased by 200 500 % by phorbol ester and also by activation of a metabotropic glutamate receptor ( mGluR 1 ) expressed in the same oocytes . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In cerebellar granule cells , activation of the type 1 metabotropic glutamate receptor ( mGluR 1 ) induced a large , oscillating increase of the L type Ba2+ current . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Perisynaptic location of metabotropic glutamate receptors mGluR 1 and mGluR 5 on dendrites and dendritic spines in the rat hippocampus . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Stimulation of two metabotropic glutamate receptor subtypes , mGluR 1 and mGluR 5 , triggers the release of Ca2+ from intracellular stores through the inositol ( 1 , 4 , 5 ) trisphosphate ( InsP 3 ) pathway . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of metabotropic glutamate receptor subtype mGluR 1 contributes to post traumatic neuronal injury . ^^^ The role of phospholipase C coupled ( group 1 ) metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) in post traumatic neuronal injury was examined using rat in vivo and in vitro models . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunocytochemical localization of the mGluR 1 alpha metabotropic glutamate receptor in the dorsal cochlear nucleus . ^^^ We demonstrate that the metabotropic glutamate receptor mGluR 1 alpha is enriched in two interneuron cell populations in the dorsal division of the cochlear nucleus . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Homology modeling of metabotropic glutamate receptors . ( mGluRs ) structural motifs affecting binding modes and pharmacological profile of mGluR 1 agonists and competitive antagonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study , the distribution of glutamate receptors was examined with preembedding immunocytochemistry , using 14 antibodies to ionotropic ( GluR 1 , GluR2 / 3 , GluR 4 , GluR 5 7 , GluR6 / 7 , KA 2 , NR 1 , NR2A / B , delta 1 / 2 ) and metabotropic ( mGluR 1 alpha , mGluR2 / 3 , mGluR 5 ) glutamate receptor subtypes . ^^^ Distribution of some glutamate receptors in the DCN shows similarities to that of the cerebellum , where delta 2 and mGluR 1 alpha may modulate neurotransmission at parallel fiber synapses , while mGluR 2 and / or mGluR 3 may modulate mossy terminal function . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Examination of levels of mRNA for type 1 inositol 1 , 4 , 5 trisphosphate receptor ( IP3R1 ) , inositol 1 , 4 , 5 trisphosphate 3 kinase ( IP3K ) and metabotropic glutamate receptor 1 ( mGluR 1 ) in cerebellar Purkinje neurons by in situ hybridization revealed significant decreases in cellular levels of mRNA encoding both IP3R1 and mGluR 1 in the ethanol treated group compared with controls , but levels of IP3K mRNA were not altered . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In situ hybridisation and immunocytochemical studies reveal the presence of several NMDA ( NMDAR 1 , NMDAR2C ) , non NMDA ( GluR 1 , GluR 2 , GluR 4 ) and metabotropic ( mGluR 1 ) glutamate receptor subunits in the SCN . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We found that , in mice deficient in the type 1 metabotropic glutamate receptor ( mGluR 1 ) , the regression of supernumerary CFs ceases by the end of the second postnatal week , which is about one week earlier than in normal mice . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study we have used in situ hybridisation techniques to examine the mRNA expression of group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 both linked to phosphoinositide hydrolysis ) in the hippocampus of amygdala kindled animals sacrificed 24 h , 7 days or 28 days following the last electrically evoked stage 5 seizure , and in implanted non stimulated control rats . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Distribution of glutamate receptors in these two synapse populations in rat cerebella was studied using preembedding immunocytochemistry with antibodies to GluR 1 , GluR2 / 3 , GluR 5 7 , NR 1 , delta 1 / 2 , and mGluR 1 alpha . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
These analogues interact with glutamate receptors of the central nervous system , especially the ligand 4T [ ( 2S , 4S ) 4 methylglutamic acid ] at the metabotropic glutamate receptor mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of group 1 receptors ( mGluR 1 and / or mGluR 5 ) on presynaptic somata / dendrites led to an increase in spike dependent transmitter release , whereas activation of the group 3 receptors ( mGluR 4 , 7 , and / or 8 ) on presynaptic terminals suppressed glutamate and GABA release onto SON neurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the present patch clamp study , performed in thin cerebellar slices prepared from adult mutant mice deficient in metabotropic glutamate receptors of the mGluR 1 subtype , only 15 % of Purkinje cells remained multiply innervated by climbing fibres , but motor coordination was largely impaired in these animals . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have studied the effect of metabotropic glutamate receptors on the second messenger cAMP , and how it varies with age in light and dark reared cats ; the overall level of the metabotropic glutamate receptors mGluR 1 , 2 / 3 , and 5 during development ; the laminar distribution of these receptors ; and how the physiological effect of the metabotropic glutamate receptor agonist ACPD varies with layer . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have previously shown that metabotropic glutamate receptor ( mGluR 1 ) stimulation initiates a phosphorylation cascade , triggering rapid association of some mRNAs with translation machinery near synapses , and leading to protein synthesis . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor subtype 1 alpha ( mGluR 1 alpha ) immunoreactivity in ependymal cells of the rat caudal medulla oblongata and spinal cord . ^^^ Immunohistochemical study of the distribution of glutamate receptor subunits 1 4 ( GluR 1 4 ) , NMDA receptor subunit 1 and metabotropic glutamate receptor subtypes 1 3 ( mGluR 1 3 ) in the ependymal cells of the caudal medulla oblongata and upper thoracic spinal cord was carried out . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
It is shown that glutamate and N methyl D aspartate neurotoxicity are prevented by the following compounds : 1 amino cyclo pentane trans 1 , 3 dicarboxylic acid , agonist of mGluR 1 , 2 , 3 and 5 ; 3 , 5 dihydroxyphenylglycine , agonist of mGluR 1 and 5 ; S 4 carboxy 3 hydroxyphenylglycine , agonist of mGluR 5 and antagonist of mGluR 1 ; trans azetidine 2 , 4 dicarboxylic acid , agonist of mGluR 5 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To define more rigorously the receptor specificity of NAAG , cloned rat cDNAs for mGluR 1 6 were transiently or stably transfected into Chinese hamster ovary cells and human embryonic kidney cells and assayed for their second messenger responses to the two endogenous neurotransmitters , glutamate and NAAG , as well as to metabotropic receptor agonists , trans 1 aminocyclopentane 1 , 3 dicarboxylate ( trans ACPD ) and L 2 amino 4 phosphonobutyrate ( L AP 4 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Finally , pretreatment with the mixed metabotropic glutamate receptor ( mGluR ) 1 / mGluR2 antagonist agonist ( S ) 4 carboxy 3 hydroxyphenylglycine ( CHPG ) prevented hippocampal damage produced by the mGluR 1 agonist ( RS ) 3 , 5 dihydroxyphenylglycine ( DHPG ) , but did not protect against 2 ICA hippocampal lesions . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The role of the metabotropic glutamate receptor 1 ( mGluR 1 ) in synaptic plasticity was investigated in vivo in the intact hippocampus of mutant mice lacking this receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In order to confirm the existence of metabotropic glutamate receptors in astroglial cultures and to provide information on different receptor subtypes , the expression of different mGluRs was analysed in cultures highly enriched in rat astroglial cells . mRNA levels for mGluR 1 , 2 , 3 , 4 , 7 were undetectable by Northern blot analysis in primary type 1 astroglial cultures derived from total cerebral hemispheres , cerebral cortex and striatum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptors modulate neuronal activity but expression and alternative splicing of their subtypes ( mGluR 1 mGluR8 ) during early neuronal differentiation are essentially unknown . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A monoclonal antibody shows discrete cellular and subcellular localizations of mGluR 1 alpha metabotropic glutamate receptors . ^^^ The metabotropic glutamate receptor , mGluR 1 alpha , is postsynaptic in excitatory synapses in many populations of neurons and mediates long term responses . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The expression of metabotropic glutamate receptor ( mGluR ) mRNA ( mGluR 1 8 ) was studied in the suprachiasmatic ( SCN ) and arcuate ( ARC ) nuclei . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Olfactory bulb mitral cells express group 1 ( mGluR 1 ) , group 2 ( mGluR 2 ) , and group 3 ( mGluR 7 and mGluR 8 ) metabotropic glutamate receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor mGluR 5 , but not the closely related mGluR 1 , is expressed in cultured astrocytes , and this expression is up regulated by specific growth factors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The distribution of ionotropic glutamate receptor subunits GluR 1 , GluR2 / 3 and NMDAR 1 , and meta botropic receptor mGluR 1 alpha was studied in the monkey substantia nigra . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Of the eight subtypes cloned to date , mGluR 1 and mGluR 5 are coupled to phosphoinositide hydrolysis in expression systems , and both are activated by the glutamate analogue 1 aminocyclopentane 1S , 3R dicarboxylic acid . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have isolated clones of a novel splice variant of metabotropic glutamate receptor type 1 ( mGluR 1 ) from a human cerebellum cDNA library . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Differential plasma membrane distribution of metabotropic glutamate receptors mGluR 1 alpha , mGluR 2 and mGluR 5 , relative to neurotransmitter release sites . ^^^ Two group 1 metabotropic glutamate receptor subtypes , mGluR 1 and mGluR 5 , have been reported to occur in highest concentration in an annulus surrounding the edge of the postsynaptic membrane specialisation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Type 1 metabotropic glutamate receptors ( mGluR 1 ) mediate the effects of cis ACPD . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Halothane , F 3 , and ethanol inhibited mGluR 5 induced Ca ( 2+ ) dependent Cl currents , yet pharmacologically relevant concentrations of these compounds had little effect on the glutamate induced currents in the oocytes expressing mGluR 1 . ^^^ The protein kinase C ( PKC ) inhibitor GF109203X enhanced the glutamate induced current , and the PKC activator phorbol 12 myristate 13 acetate inhibited this current in the oocytes expressing mGluR 5 , but these compounds had little effect on mGluR 1 function . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mGluR 1 metabotropic glutamate receptor is a G protein coupled receptor that exists as different C terminal splice variants . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study we have used in situ hybridization to investigate the distribution of metabotropic glutamate receptors mGluR 1 7 messenger RNA in the rat spinal cord in a model of inflammatory hyperalgesia . ^^^ In situ hybridization with specific oligonucleotide probes was used to localize metabotropic glutamate receptor messenger RNAs . mGluR 1 , 3 5 and 7 subtype messenger RNA was detected in the gray matter of the spinal cord with distribution being specific for the different subtypes . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The amacrine cells express ionotropic ( NMDA , AMPA and kainate ) and metabotropic ( mGluR 1 , mGluR 2 , mGluR 4 and mGluR 7 ) glutamate receptors and may take up glutamate from the synaptic cleft . 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Localization of metabotropic glutamate receptor subtypes , mGluR 1 , mGluR1alpha , mGluR2 / 3 , mGluR4a , mGluR 5 , mGluR7a , mGluR7b , and mGluR 8 , was examined in some of the target areas of projection fibers from the main and accessory olfactory bulbs ( MOB and AOB ) by using subtype specific antibodies . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Pharmacological analysis showed that antagonists to each mGluR subtype significantly decreased the electrophysiological response to odorant amino acids . alpha Methyl L CCG1 / ( 2S , 3S , 4S ) 2 methyl 2 ( carboxycyclopropyl++ + ) glycine ( MCCG ) , a known antagonist to mGluR 3 , and ( S ) 4 carboxyphenylglycine ( S 4CPG ) , a specific antagonist to mGluR 1 , each significantly reduced olfactory receptor responses to L glutamate . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To examine the specific roles of group 1 metabotropic glutamate receptors ( mGluRs ) in nociceptive processing , we examined the effects of intrathecal ( i . t . ) treatment with antibodies raised against the C terminals of mGluR 1 and mGluR 5 in various rat pain models . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Although immunoblotting of mGluR 1 and mGluR2 / 3 did not show apparent differences between the pair fed and the ethanol fed groups , the overall results suggest that the effect of prenatal ethanol exposure was selectively through a pathway mediated by the metabotropic glutamate receptor . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Age differences in the expression of cerebellar metabotropic glutamate receptor 1 ( mGluR 1 ) and inositol 1 , 4 , 5 trisphosphate receptor ( IP3R ) were investigated using male C57BL / 6NNIA mice 5 , 15 and 24 months of age . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Analysis of glutamate receptors ( GluRs ) in symptomatic 12 week old R6 / 2 mice revealed decreases compared with age matched littermate controls in the type 1 metabotropic GluR ( mGluR 1 ) , mGluR 2 , mGluR 3 , but not the mGluR 5 subtype of G protein linked mGluR , as determined by [ 3H ] glutamate receptor binding , protein immunoblotting , and in situ hybridization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Thus , at the level of the postsynaptic membranes of PCs , induction of LTD requires concommitent activation of voltage gated calcium channels ( VGCCs ) and of ionotropic and metabotopic glutamate receptors , of the alpha amino 3 hydroxy 5 methyl isoxalone 4 propionate ( AMPA ) and mGluR 1 alpha types respectively . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Since AMPA receptors mediate OFF responses in OFF bipolar cells , two distinct types of glutamate receptors effectively operate for ON and OFF responses . mGluR 1 and mGluR 5 are both coupled to inositol triphosphate ( IP 3 ) / calcium signal transduction with an identical agonist selectivity . ^^^ Single cell intracellular calcium ( [ Ca2+ ] 1 ) recordings indicated that glutamate evokes a non oscillatory and oscillatory [ Ca2+ ] 1 response in mGluR 1 expressing and mGluR 5 expressing cells , respectively . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In ventral midbrain dopamine neurons , activation of metabotropic glutamate receptors ( mGluR 1 ) mobilized calcium from caffeine / ryanodine sensitive stores and increased an apamin sensitive potassium conductance . ^^^ The rapid rise and brief duration of synaptically released glutamate in the extracellular space can therefore mediate a rapid excitation through activation of ionotropic receptors , followed by inhibition through the mGluR 1 receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Inhibitor constants ( Ki ) obtained for L HCSA , L CSA , L CA and L SOS in [ 3H ] glutamate receptor binding studies with mGluR1alpha cells indicated that L HCSA , L CSA , L CA and L SOS can bind specifically to mGluR 1 with L HCSA showing the highest affinity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate exposure upregulates the expression of mGluR 5 in hippocampal HT 22 cells and mGluR 1 in cortical primary cultures . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
All these proteins interacted with metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) as well as several hippocampal proteins in vitro . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
As metabotropic glutamate receptor type 1 ( mGluR 1 ) is known to couple L type Ca2+ channels and ryanodine receptors ( RyR , Chavis et al . , 1996 ) in cerebellar granule cells , we examined if such a coupling could activate a Ca2+ sensitive K+ channel , the big K+ ( BK ) channel , in cultured cerebellar granule cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunohistochemical localization of the mGluR1beta metabotropic glutamate receptor in the adult rodent forebrain : evidence for a differential distribution of mGluR 1 splice variants . ^^^ Alternative splicing has been shown to occur at the metabotropic glutamate receptor 1 ( mGluR 1 ) gene . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Antisense ablation of type 1 metabotropic glutamate receptor mGluR 1 inhibits spinal nociceptive transmission . ^^^ Electrophysiological and behavioral studies point to a role of group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) in mediating spinal nociceptive responses in rats . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study we have addressed the identification of the metabotropic glutamate receptor ( mGluR ) involved in the facilitation of glutamate release in nerve terminals from the cerebral cortex . mGluR 1 and 5 are coupled to phosphoinositide hydrolysis and the activation of these receptors with the specific agonist 3 , 5 dihydroxyphenylglycine ( DHPG ) enhances the release of glutamate . ^^^ These results indicate therefore , that the facilitation of glutamate release is unlikely to be due to the activation of mGluR 1 but related to another phosphoinositide coupled mGluR . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The expression of group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) and inositol 1 , 4 , 5 trisphosphate receptor type 1 ( IP3R1 ) mRNA was studied by in situ hybridization in the developing rat hippocampus after in utero hypoxia ischemia . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Agonist selectivity of mGluR 1 and mGluR 2 metabotropic receptors : a different environment but similar recognition of an extended glutamate conformation . ^^^ To investigate the structural requirements for selective activation or blockade of metabotropic glutamate receptors , we developed a pharmacophore model for group 1 ( mGluR 1 ) and group 2 ( mGluR 2 ) agonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Recent reports have outlined that cerebellar long term depression requires the activation of subtype 1 metabotropic glutamate receptors , since long term depression is impaired in subtype 1 metabotropic glutamate receptor ( mGluR 1 ) knockout mice . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Identification , cloning and analysis of expression of a new alternatively spliced form of the metabotropic glutamate receptor mGluR 1 mRNA1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Role of metabotropic glutamate receptor subtype mGluR 1 in brief nociception and central sensitization of primate STT cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
BACKGROUND : Group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) are coupled to inositol trisphosphate / Ca2+ signaling via G proteins and play an important role in excitatory synaptic transmission . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The N terminal fragment of Cupidin , which was able to associate with metabotropic glutamate receptor 1 ( mGluR 1 ) , also interacted with F actin in vitro . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We used microiontophoretic techniques to investigate whether metabotropic glutamate receptors group 1 ( mGluR 1 ) are also involved in the transmission of IHC afferents of the guinea pig . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Of the group 1 metabotropic glutamate receptors , mGluR 5 may be involved in plasticity , but mGluR 1 is unlikely to be . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study we have used double label immunocytochemistry to analyze the expression of the glutamate receptor subunits GluR 1 , GluR2 / 3 , NR 1 , mGluR 1 , and mGluR 5 in the dopaminergic cells of the striatum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Previously we have demonstrated that activation of group 1 mGluRs ( mGluR 1 and mGluR 5 ) with the broad spectrum mGluR agonist 1S , 3R 1 amino 1 , 3 cyclopentanedicarboxylate ( ACPD ) produced potentiation of ionotropic glutamate responses . ^^^ These results suggest that both mGluR 5 and mGluR 1 may act to enhance ionotropic glutamate responses but the two types of mGluRs may have different intracellular mechanisms of action . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To elucidate the role of phospholipase Cbeta ( PLCbeta ) isozymes in the cerebellum , the distributions of PLCbeta 3 and PLCbeta 4 were examined in wild type and PLCbeta 4 deficient mutant mice using immunohistochemistry , and the functions were evaluated by measurement of type 1 metabotropic glutamate receptor ( mGluR 1 ) mediated inward current and Ca ( 2+ ) mobilization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here , using 31P NMR , we examine whether activation of the metabotropic glutamate receptor 1 ( mGluR 1 ) , which induces the production of IP 3 , could modulate phospholipid metabolism in human embryonic kidney 293 cells . mGluR1alpha but not ionotropic glutamate receptor 1 expressing cells stimulated with glutamate exhibited a drastic reduction in the phosphorylcholine level , with corresponding increases in the level of phosphatidylcholine , a major phospholipid component . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Preliminary pharmacological studies showed that ( 3S , 4S ) 3 is an agonist of metabotropic glutamate receptors of type 1 ( mGluR 1 ) and a weak antagonist of mGluR 4 but has no discernible activity with respect to mGluR 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Expression of metabotropic glutamate receptor subtype mRNA ( mGluR 1 8 ) in human cerebellum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Endogenous glutamate , by activating NMDA , AMPA or mGluR 1 receptors , may contribute to the brain damage occurring acutely after status epilepticus , cerebral ischemia or traumatic brain injury . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptors fall into the following three groups , each containing two or more individual receptor proteins : group 1 ( mGluR 1 , mGluR 5 ) , group 2 ( mGluR 2 , mGluR 3 ) , and group 3 ( mGluR 4 , mGluR 6 , mGluR 7 and mGluR 8 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Temporal lobe epilepsy associated up regulation of metabotropic glutamate receptors : correlated changes in mGluR 1 mRNA and protein expression in experimental animals and human patients . ^^^ Recent data point to excitatory class 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) as interesting candidates . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Another chimeric hCaR with the same region of sequence replaced by the corresponding sequence from metabotropic glutamate receptor subtype 1 ( mGluR 1 ) still was activated by extracellular Ca ( 2+ ) ( [ Ca ( 2+ ) ] ( o ) ) , but its function was severely compromised . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The receptor protein expression of glutamate receptors mGluR 1 , GluR 2 , GluR5 / 7 and NMDAR 1 were not modified in response to PCP treatment . 6 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Height different genes encoding metabotropic glutamate receptors ( mGluRs ) subtypes have been described ( mGluR 1 8 ) , having a distinct distribution in the brain . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the presence of BDNF , pharmacological activation of metabotrophic glutamate receptor subtype 1 ( mGluR 1 ) by ( S ) 3 , 5 dihydrophenylglycine ( 3 , 5 DHPG ) also lead to a 32 % enhancement of mIPSCs . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Targeted deletion of metabotropic glutamate receptor subtype 1 ( mGluR 1 ) gene can cause defects in development and function in the cerebellum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Previously , we produced the whole extracellular region of metabotropic glutamate receptor subtype 1 ( mGluR 1 ) in a soluble form . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Brief tetanic stimulation of parallel fibers in rat and mouse cerebellar slices evokes a slow excitatory postsynaptic current in Purkinje cells that is mediated by the mGluR 1 subtype of metabotropic glutamate receptors . ^^^ The mGluR 1 EPSC was induced by local parallel fibre stimulation in the presence of the ionotropic glutamate receptor antagonists NBQX and D APV and the GABAA receptor antagonists bicuculline or picrotoxin . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Neither the mGluR 1 specific agonist ( S ) dihydroxyphenylglycine nor any of the ionotropic glutamate receptor ligands such as kainate , AMPA and MK 801 had strong effects ( except for the competitive NMDA antagonist CGS 19755 , which produced 20 40 % inhibition at 100 microM ) suggesting that , at low nM concentrations , [ 3H ] NAAG binds predominantly to metabotropic glutamate receptors , particularly those of the mGluR 2 type . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( mGluR 1 ) expresses at the cell surface as disulfide linked dimers and can be reduced to monomers with sulfhydryl reagents . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors ( mGluR 1 and 5 ) couple to intracellular calcium pools by a family of proteins , termed Homer , that cross link the receptor to inositol trisphosphate receptors . mGluRs also couple to membrane ion channels via G proteins . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Stimulation of group 1 metabotropic glutamate receptors ( mGluR 1 and 5 ) activates G protein coupled phospholipase C ( PLC ) to release 1 , 2 diacylglycerol ( DAG ) and arachidonic acid ( ArAc ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we have determined three different crystal structures of the extracellular ligand binding region of mGluR 1 in a complex with glutamate and in two unliganded forms . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We also made use of truncation and deletion mutants of the CaR and CaR / metabotropic glutamate receptor type 1 ( mGluR 1 ) chimeras to study both the site of action of R 568 and the effect of the Leu125Pro activating mutation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Among antagonists of group 1 metabotropic glutamate receptors , the mGluR 5 selective 6 methyl 2 ( phenylethynyl ) pyridine inhibited long term potentiation in the CA 1 region of hippocampal slices from 30 day old rats , whereas ( RS ) 1 aminoindan 1 , 5 dicarboxylic acid and cyclopropan [ b ] chromen 1a carboxylic acid ethylester , which are more selective for mGluR 1 , failed to inhibit long term potentiation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Detection of a surface exposed PEST like sequence in the metabotropic glutamate receptor mGluR 1 alpha . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Construction of a high affinity zinc binding site in the metabotropic glutamate receptor mGluR 1 : noncompetitive antagonism originating from the amino terminal domain of a family C G protein coupled receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The effects of selective blockade of group 1 metabotropic glutamate receptor subtype 1 ( mGluR 1 ) on neuronal cell survival and post traumatic recovery was examined using rat in vitro and in vivo trauma models . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor mGluR 1 undergoes alternative splicing to generate isoforms differing in C terminal sequence . ^^^ Our results indicate that these splice variants of mGluR 1 utilize different targeting pathways and suggest that this may be a general phenomenon in the metabotropic glutamate receptor gene family . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Most previous studies have focused on the group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) and activation of phospholipase C signaling by these receptors in modulating nociception . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Expression of the Na ( + ) K ( + ) 2Cl ( ) cotransporter and metabotropic glutamate receptors ( mGluR 1 and 5 ) was detected in cortical neurons via immunoblotting and immunofluorescence staining . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
LTD requires activation of metabotropic glutamate receptor subtype 1 ( mGluR 1 ) and its downstream signalling pathways , which invariably involves phospholipase Cbetas ( PLCbetas ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Tetanic stimulation of parallel fibres ( PFs ) produces a slow EPSP ( sEPSP ) or slow EPSC ( sEPSC ) in Purkinje neurones ( PNs ) , mediated by type 1 metabotropic glutamate receptors ( mGluR 1 ) . ^^^ The conductance change underlying the sEPSP was investigated with rapid photolytic release of L glutamate from nitroindolinyl ( NI ) caged glutamate with ionotropic glutamate receptors blocked , and showed a slow mGluR 1 activated cation channel . 2 . ^^^ The slow current was inhibited reversibly by 1 mM ( R , S ) MCPG or the non competitive mGluR 1 antagonist CPCCOEt ( 20 microM ) , indicating activation of metabotropic type 1 glutamate receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate induces focal adhesion kinase tyrosine phosphorylation and actin rearrangement in heterologous mGluR 1 expressing CHO cells via calcium / calmodulin signaling . ^^^ Group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 ) stimulate phospholipase C ( PLC ) and lead to mobilization of intracellular Ca ( 2+ ) and activation of protein kinase C ( PKC ) . ^^^ In this investigation , using heterologous receptor expressing Chinese hamster ovary ( CHO ) cells , we showed that stimulation of mGluR 1 or mGluR 5 with glutamate rapidly increases tyrosine phosphorylation of focal adhesion kinase ( FAK ) ( maximum at 1 3 min ) in a dose dependent manner ( half maximal responses at approximately 2 microM ) . ^^^ In mGluR 1 expressing cells , the glutamate induced increase of FAK tyrosine phosphorylation was blocked by not only the PLC inhibitor , U 73122 , but also depletion of intracellular Ca ( 2+ ) and effectively abrogated by calmodulin ( CaM ) inhibitors , calmidazolium and fluphenazine . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In normal control animals , regional differences in the expression of several glutamate receptor subunit / subtypes , e . g . , NR 1 and NR2A subunits of the N methyl D aspartic acid ( NMDA ) receptor , GluR 2 and KA 2 subtypes of non NMDA receptors , and mGluR 1 and mGluR 7 metabotropic glutamate receptors , were consistent with previous results from studies using in situ hybridization histochemistry , suggesting that the real time quantitative PCR method was a reliable procedure for evaluation of changes in mRNA expression . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Presynaptic modulation by group 3 metabotropic glutamate receptors ( mGluRs ) of the excitatory postsynaptic potential mediated by mGluR 1 in rat cerebellar Purkinje cells . ^^^ These data suggest that glutamate released by parallel fibres activates group 3 mGluR autoreceptors , depressing both iGluR and mGluR 1 mediated EPSPs . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To elucidate the relevance of metabotropic glutamate receptors ( mGluRs ) to the selective vulnerability of motor neurons in the spinal cord in patients with amyotrophic lateral sclerosis ( ALS ) , we investigated the distribution of mRNAs coding mGluR 1 5 in the normal human spinal cord . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of the type 1 metabotropic glutamate receptor ( mGluR 1 ) signaling pathway in the cerebellum involves activation of phospholipase C ( PLC ) and protein kinase C ( PKC ) for the induction of cerebellar long term depression ( LTD ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( mGluR 1 ) is a G protein coupled receptor and is expressed in the medium spiny projection neurons of mouse striatum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Cellular localization of metabotropic glutamate receptors mGluR 1 , 2 / 3 , 5 and 7 in the main and accessory olfactory bulb of the rat . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The beta isoforms of phospholipase C ( PLCbetas ) are thought to mediate signals from metabotropic glutamate receptor subtype 1 ( mGluR 1 ) that is crucial for the modulation of synaptic transmission and plasticity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Reverse dialysis of the group 1 agonist ( RS ) 3 , 5 dihydroxyphenylglycine ( DHPG ) into the nucleus accumbens resulted in an increase in extracellular glutamate levels that was mediated by the mGluR 1 subtype and depended on voltage dependent Na ( + ) and Ca ( 2+ ) conductance . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Roles of glutamate receptor delta 2 subunit ( GluRdelta 2 ) and metabotropic glutamate receptor subtype 1 ( mGluR 1 ) in climbing fiber synapse elimination during postnatal cerebellar development . ^^^ Previous studies revealed that deletion of the glutamate receptor delta 2 subunit ( GluRdelta 2 ) gene results in persistent multiple CF innervation of PCs with impaired PF synaptogenesis , whereas mutation of the metabotropic glutamate receptor subtype 1 ( mGluR 1 ) gene causes multiple CF innervation with normal PF synaptogenesis . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Spinal cord injury ( SCI ) leads to an increase in metabotropic glutamate receptor subtype 1 ( mGluR 1 ) immunoreactivity in the peri lesion area . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Furthermore , novel expression of metabotropic glutamate receptor 1 ( mGluR 1 ) , mGluR 4 , and mGluR 5 by human brain and dermal microvascular endothelial cells was demonstrated by reverse transcription PCR , in situ hybridization , immunofluorescence , and Western blot analysis . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor subtype 1 ( mGluR 1 ) plays an essential role in the cerebellar long term depression ( LTD ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we describe the use of real time quantitative PCR using a fluorescent TaqMan probe , to study the regional differences in expression of glutamate receptor subunit / subtype genes ( NR 1 , NR2A , GluR 2 , KA 2 , mGluR 1 , mGluR 7 ) in the central vestibular system including the vestibular nucleus complex , inferior olive and cerebellar flocculus . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( mGluR 1 ) is highly expressed in striatonigral projection neurons of rat striatum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors , mGluR 1 and mGluR 5 , control glutamatergic neurotransmission by acting both postsynaptically and presynaptically . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
At the cerebellar parallel fiber Purkinje cell synapse , isolated presynaptic activity induces fast excitatory postsynaptic currents via ionotropic glutamate receptors while repetitive , high frequency , presynaptic activity can also induce a slow excitatory postsynaptic current that is mediated by metabotropic glutamate receptors ( mGluR 1 EPSC ) . ^^^ Here we investigated the involvement of glutamate uptake in the expression of the mGluR 1 EPSC . ^^^ Inhibitors of glutamate uptake led to a large increase of the mGluR 1 EPSC . ^^^ Depression of the mGluR 1 EPSC by rapid pressure application of ( S ) MCPG at varying time intervals after tetanic stimulation of the parallel fibers indicated that the glutamate concentration in the peri and extrasynaptic space decayed with time constants of 36 and 316 ms under control conditions and with inhibition of glutamate uptake , respectively . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study , we characterized the glutamate or second messenger kinase dependent internalization of the rat metabotropic glutamate receptor 1 ( mGluR 1 ) splice variants 1a , 1b , and 1c , and assessed the arrestin and dynamin dependence of these processes . ^^^ Quantification of glutamate induced mGluR 1 splice variant internalization provided by enzyme linked immunosorbent assay and confirmed by immunofluorescent microscopy indicated that each splice variant underwent rapid internalization , which was strongly inhibited by coexpression of dominant negative mutant ( DNM ) arrestin or dynamin . ^^^ In addition glutamate induced rapid translocation of arrestin 2 green fluorescent protein ( GFP ) or arrestin 3 GFP from cytosol to membrane was observed in cells expressing mGluR 1 splice variants . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In mouse cerebellar Purkinje cells ( PCs ) , Ca2+ ( o ) drastically broadened the effective dose range for glutamate analogs in which native mGluR 1 mediated cation current and intracellular Ca2+ mobilization were evoked . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The group 1 metabotropic glutamate receptors , mGluR 1 and mGluR 5 , exhibit a high degree of sequence homology , and are often found co expressed in the same neuronal populations . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
These data show that activation of mGluR 1 , but probably not mGluR 5 , can modulate visual responses of SSC neurones in vivo , and that this could be via presynaptic inhibition of glutamate release from either retinal or , possibly , cortical afferents . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mechanism underlying the upregulation of NMDA receptor function by group 1 metabotropic glutamate receptors ( mGluRs ) , including mGluR 1 and 5 , is not known . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Although GRKs contribute to metabotropic glutamate receptor 1 ( mGluR 1 ) inactivation , beta arrestins do not appear to be required for mGluR 1 G protein uncoupling . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This study was designed to examine the effects of intrathecal ( i . t . ) infusion of a metabotropic glutamate receptor 1 ( mGluR 1 ) antisense oligonucleotide , concomitant with chronic morphine treatment , on the development of tolerance to morphine ' s antinociceptive effects . 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We present a hypothesis to explain receptor activation by mutations in this region based on the recently described three dimensional structure of the related metabotropic glutamate type 1 receptor ( mGluR 1 ) . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The enrichment of mGluR7a in the main GABAergic , as well as in the glutamatergic , innervation of mGluR 1 alpha / somatostatin expressing interneurons suggests that their activation is under unique regulation by extracellular glutamate . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The striatum as a target for anti rigor effects of an antagonist of mGluR 1 , but not an agonist of group 2 metabotropic glutamate receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the medial vestibular nuclei ( MVN ) of rat brainstem slices , the role of group 2 and 3 metabotropic glutamate receptors ( mGluRs ) and of the subtypes of group 1 mGluRs : mGluR 1 , mGluR 5 , was investigated in basal synaptic transmission and in the induction and maintenance of long term potentiation ( LTP ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In addition , MPEP ( a selective mGluR 5 antagonist ) partially reduced ouabain , endobain E and glutamate responses and the selective mGluR 1 antagonist LY 367385 showed no activity at all . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Recently , members of the Homer protein family have been shown to cluster type 1 metabotropic glutamate receptors ( mGluR 1 ) in the plasma membrane and to interact with InsP ( 3 ) R in the endoplasmic reticulum of neurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Three different crystal structures of the extracellular ligand binding region ( LBR ) of mGluR 1 have been determined , in a complex with glutamate and in two unliganded forms . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have identified a new class of non competitive metabotropic glutamate receptor 1 ( mGluR 1 ) antagonists , 2 , 4 dicarboxy pyrroles which are endowed with nanomolar potency . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In metabotropic glutamate receptor subtype 1 ( mGluR 1 ) null ( mGluR 1 / ) mice , cerebellar long term depression ( LTD ) and several forms of memory are impaired . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The influence of the arthritic condition induced in vivo on synaptic transmission and group 1 metabotropic glutamate receptor ( mGluR 1 and mGluR 5 ) function was examined in vitro using whole cell voltage clamp recordings of neurons in the central nucleus of the amygdala ( CeA ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors ( mGluR 1 and mGluR 5 subtypes ) are positively coupled to phosphoinositide hydrolysis through G proteins and are densely expressed in medium sized projection neurons of striatum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptors form a family of currently eight subtypes ( mGluR 1 8 ) , subdivided into three groups ( 1 3 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Determination of group 1 metabotropic glutamate receptor subtypes involved in the frequency of epileptiform activity in vitro using mGluR 1 and mGluR 5 mutant mice . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Expression of the metabotropic glutamate receptor ( mGluR ) subtypes mGluR 1 and mGluR 5 and the ionotropic glutamate receptor ( iGluR ) subtypes iGluR 1 and iGluR 4 were detected by RT PCR and immunofluorescence analysis in cultured astrocytes . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( mGluR 1 ) plays a crucial role in synaptic plasticity and motor learning in the cerebellum . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor subtype 1 ( mGluR 1 ) is a G protein coupled receptor that stimulates the inositol 1 , 4 , 5 trisphosphate Ca2+ signaling cascade , whereas Cav2 . 1 is a pore forming channel protein of P / Q type voltage sensitive Ca2+ channels . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activity of thalamic neurons has been shown to be modulated via type 1 metabotropic glutamate receptor ( mGluR 1 ) activation , which initiates an intracellular Ca signaling cascade involving phospholipase Cbeta 4 ( PLCbeta 4 ) and leading to the activation of conventional protein kinase C ( cPKC ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Photorelease of L glutamate in 1 msec from 4 methoxy 7 nitroindolinyl or 7 nitroindolinyl caged glutamate in cerebellar slices was used to isolate and study postsynaptic mechanisms coupling mGluR 1 to the cation channel . ^^^ L Glutamate immediately activated a glutamate transporter current , followed by the slow mGluR 1 activated conductance . ^^^ The selective src PTK inhibitor PP 1 ( 10 microm intracellularly ) potentiated submaximal mGluR 1 currents evoked by low L glutamate concentrations but had no effect on maximal responses ( 80 or 160 microm L glutamate ) . ^^^ L Glutamate evoked mGluR 1 currents and parallel fiber sEPSCs were reversibly and completely inhibited by protein tyrosine phosphatase ( PTP ) inhibitor bpV ( phen ) ( 50 200 microm ) and by nonselective phosphatase inhibitor orthovanadate ( 0 . 5 or 1 mm ) . mGluR 1 currents were completely inhibited by GDPbetaS applied intracellularly ( 5 mm ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Long ( > 12 s ) exposure to glutamate mimicked the caffeine effect , i . e . it inhibited the GABAA current by elevating [ Ca2+ ] 1 through mGluR 1 receptor activation and consequent IP 3 generation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The new amino acids were tested toward ionotropic and metabotropic glutamate receptor subtypes ; both of them behaved as antagonists at mGluR 1 , 5 and as agonists at mGluR 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To investigate the expression of interleukin 2 ( IL 2 ) , metabotropic glutamate receptor subunit 1 ( mGluR 1 ) and estrogen receptor ( ER ) in neurons of the rat central nervous system ( CNS ) and identify the coexistence possibility of these immune neuro endocrine substances in the central neurons , the tri labeling immunocytochemical technique with different species specific primary antibodies ( goat anti IL 2 antibody , rabbit anti mGluR 1 antibody and mouse anti ER antibody ) were used to incubate two serial neighbor sections ( one for demonstrating IL 2 , another for mGluR 1 and ER ) of the cerebral cortex , medulla oblongata and spinal cord . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Molecular dynamic simulation of the ligand receptor complexes of the aminoterminal domain of the metabotropic glutamate receptor mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
These results show that , in addition to taste mGluR 4 and the heteromer of T1R1 and T1R3 , mGluR 1 alpha may function as a receptor for glutamate ( umami ) taste sensation . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors ( mGluRs ) are involved in long term synaptic plasticity and neuroprotection in the striatum , but the specific role ( s ) of mGluR 1 and mGluR 5 remain poorly understood . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To determine which glutamate receptors are primarily responsible for these nociceptive behaviours , we pretreated additional groups of rats with selective antagonists for N methyl D aspartate ( NMDA ) , alpha amino 3 hydroxy 5 methyl 4 isoxazole proprionic acid / kainate ( AMPA / KA ) and group 1 metabotropic glutamate receptors ( mGluR 1 and 5 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mouse thalamus also has been shown to express a high level of metabotropic glutamate receptor type 1 ( mGluR 1 ) , which stimulates PLCbetas through activation of Galphaq / 11 protein . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The effects of high frequency stimulation ( HFS ) of the primary vestibular afferents on synaptic transmission in the ventral part of the medial vestibular nuclei ( vMVN ) were studied during postnatal development and compared with the changes in the expression of the group 1 metabotropic glutamate receptor ( mGluR ) subtypes , mGluR 1 and mGluR 5 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we address the role of G protein coupled group 1 metabotropic glutamate receptor subtypes mGluR 1 and mGluR 5 in nociceptive processing under normal conditions and in pain related sensitization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To examine the role of mGluR 1 ( a subunit of the group 1 metabotropic glutamate receptor ) in the nociceptive responses of rats following a subcutaneous injection of formalin into the plantar surface of the hind paw , we delivered antisense oligonucleotides ( ODNs ) against mGluR 1 into the rat lumbar spinal cord ( L 3 L5 ) intrathecally using an HVJ liposome mediated gene transfer method . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate transmission via NMDA and mGluR 1 but not AMPA receptors was critical to this ERK activation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of the TRPC 1 cation channel by metabotropic glutamate receptor mGluR 1 . ^^^ Group 1 metabotropic glutamate receptors ( consisting of mGluR 1 and mGluR 5 ) are G protein coupled neurotransmitter receptors that are found in the perisynaptic region of the postsynaptic membrane . ^^^ Manipulations that interfere with TRPC 1 block the mGluR 1 evoked slow EPSC in Purkinje cells ; however , fast transmission mediated by AMPA type glutamate receptors remains unaffected . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We investigated the involvement of store operated channels ( SOCs ) and transient receptor potential ( TRP ) channels in the response to activation of the group 1 metabotropic glutamate receptor subtype 1 ( mGluR 1 ) with the agonist ( S ) 3 , 5 dihydroxyphenylglycine ( DHPG , puff application ) in dopamine neurons in rat brain slices . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The present study indicates that the blockade of striatal glutamate receptors belonging to the group 1 ( mGluR 1 and mGluR 5 ) but not stimulation of the group 2 mGluRs may normalize the function of the striatopallidal pathway in an animal model of parkinsonism , which may be important for future antiparkinsonian therapy in humans . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
LTP induction was absent in metabotropic glutamate receptor 1 ( mGluR 1 ) knockout mice , was correlated with the postsynaptic presence of mGluR1a , and required a postsynaptic Ca2+ rise . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To date , evidence has emerged indicating that N methyl d aspartate ( NMDA ) receptor antagonists , group 1 metabotropic glutamate receptor ( mGluR 1 and mGluR 5 ) antagonists , as well as positive modulators of alpha amino 3 hydroxy 5 methyl 4 isoxazolepropionic acid ( AMPA ) receptors have antidepressant like activity in a variety of preclinical models . ^^^ Further , there is also evidence implicating disturbances in glutamate metabolism , NMDA , and mGluR 1 , 5 receptors in depression and suicidality . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activity dependent changes in expression and localization of the largest major isoform of the neural cell adhesion molecule NCAM 180 and three subtypes of glutamate receptors predominantly expressed in the outer part of the molecular layer of the dentate gyrus of adult rats the NMDA receptor NR2A , the AMPA receptor GluR2 / 3 , and the metabotropic glutamate receptor mGluR 1 were investigated using postembedding immunogold labeling , and electron microscopy . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We tested this for dopamine neurones in rat brain slices by characterizing the current voltage relationship and pharmacology of EPSCs mediated by group 1 metabotropic glutamate receptor subtype 1 ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We show that both mGluR 1 and mGluR 2 are activated by Ca2+ ( o ) in the absence of glutamate in the extracellular media . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Postsynaptic metabotropic glutamate receptor mGluR 1 mediates the late component of signal propagation in the guinea pig piriform cortex : optical imaging study . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
However , GRK mediated desensitization , in the absence of phosphorylation and arrestin binding , has been reported for metabotropic glutamate receptor 1 ( mGluR 1 ) and gamma aminobutyric acid B receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Molecular modeling of the mGluR 1 metabotropic glutamate receptor transmembrane domain and construction of the model of its dimer . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The slow EPSC ( sEPSC ) of cerebellar parallel fiber > Purkinje neuron synapses is mediated by metabotropic glutamate receptor type 1 ( mGluR 1 ) activation of nonselective cation channels . ^^^ Here , the channel properties were studied with uniform calibrated photorelease of L glutamate with ionotropic receptors blocked , allowing isolation of postsynaptic processes , or with parallel fiber stimulation or mGluR 1 agonist application . ^^^ Photoreleased L glutamate triggered a Ca ( 2+ ) concentration increase in the distal dendrites with a time course similar to that of the mGluR 1 current . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
CPCCOEt , an antagonist of metabotropic glutamate receptors type 1 ( mGluR 1 ) counteracted the effect , whereas antagonists of NMDA or AMPA receptors were ineffective . ^^^ These findings indicate that glutamate inhibits PtdSer synthesis by acting on mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the hippocampal CA 1 region , metabotropic glutamate subtype 1 ( mGluR 1 ) receptors have been implicated in a variety of physiological responses to glutamate , which include modulation of synaptic transmission and plasticity , as well as neuronal excitability and synchronization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Since glutamate also acts on second messenger coupled metabotropic receptors , the expression of group 1 metabotropic glutamate receptors , mGluR 1 and mGluR 5 , was examined following similar treatment . mGluR 1 expression began to decline in the perikarya 2 days postlesion and a day later in the neuropil . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This novel facilitating effect of the group 1 mGluR activation on glutamate release is the first report of a direct facilitatory action of both mGluR 1 and mGluR 5 subtypes on sensory transmission in the spinal cord SG region . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To determine which glutamate transporters are essential for removing glutamate at these excitatory synapses , we recorded mGluR 1 mediated EPSCs from oriens lacunosum moleculare ( O LM ) interneurons in acute hippocampal slices . ^^^ However , inhibition of all glutamate transporters with TBOA ( DL threo b benzyloxyaspartic acid ) increased mGluR 1 EPSCs > 15 fold , indicating that additional transporters also shape activation of these receptors . ^^^ To identify these transporters , we examined mGluR 1 EPSCs in mice lacking GLAST ( for glutamate aspartate transporter ; EAAT 1 ) or EAAC 1 ( for excitatory amino acid carrier ; EAAT 3 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study , we characterized the effects of activation of cyclic AMP dependent protein kinase ( PKA ) on the internalization and functional coupling of the metabotropic glutamate receptor ( mGluR 1 ) splice variants mGluR1a and mGluR1b . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Both subtypes of group 1 metabotropic glutamate receptor , mGluR 1 and mGluR 5 , are expressed postsynaptically in neurons of the subthalamic nucleus ( STN ) , and their activation induces different physiological responses . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The activation of the native mGluR 1 response to Ca2+o appears to be slower than that to glutamate . ^^^ Ca2+o ( 2 mM ) also augments glutamate analog evoked , native mGluR 1 mediated inward cation current and intracellular Ca2+o mobilization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study we characterized the heterologous desensitization and internalization of the metabotropic glutamate receptor 1 ( mGluR 1 ) splice variants mGluR1a and mGluR1b following activation of endogenous G ( q / 11 ) coupled receptors in HEK 293 cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
These traits , along with a significant homology to the human calcium sensing receptor ( CaR , 34 % aa sequence identity ) , the taste receptor 1 ( T1R1 , 28 % ) , and the metabotropic glutamate receptor 1 ( mGluR 1 , 24 % ) , places GPRC6A in family C of the GPCRs . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Regulation of main olfactory bulb mitral cell excitability by metabotropic glutamate receptor mGluR 1 . ^^^ In the rodent main olfactory bulb ( MOB ) , mitral cells ( MCs ) express high levels of the group 1 metabotropic glutamate receptor ( mGluR ) subtype , mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This included relatively lower levels of all four AMPA subunits in lMAN , strikingly higher levels of the kainite subunit GluR 5 in the robust nucleus of the arcopallium ( RA ) , higher and lower levels respectively of the NMDA subunits NR2A and NR2B in most vocal nuclei and lower levels of the metabotropic group 1 subtypes ( mGluR 1 and 5 ) in most vocal nuclei and the group 2 subtype ( mGluR 2 ) , showing a unique expression pattern of very low levels in RA and very high levels in HVC . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
LY 367385 ( mGluR 1 ) and MPEP ( mGluR 5 ) , which are group 1 metabotropic glutamate receptor ( mGluR ) antagonists , were used to investigate their effects on pentylenetetrazole ( PTZ ) seizures , kindling , and kindling related learning deficits . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Altered agonist sensitivity and desensitization of neuronal mGluR 1 responses in knock in mice by a single amino acid substitution at the PKC phosphorylation site . mGluR 1 and mGluR 5 of the metabotropic glutamate receptor family are coupled to inositol trisphosphate Ca2+ signal cascades and evoke distinct Ca2+ responses in neural cells and heterologously expressing cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We show that glutamate or the metabotropic class 1 agonist S 3 , 5 dihydroxyphenyl glycine , acting through the metabotropic glutamate receptor 1 ( mGluR 1 ) , can reduce the activity of multiple axonal repellents in vitro . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Signaling of heterologously expressed mGluR 1 was examined in isolated rat sympathetic neurons by measuring glutamate mediated inhibition of native calcium currents . ^^^ To examine mGluR 1 activity when only one dimer subunit has access to glutamate ligand , wildtype mGluR 1 was coexpressed with mGluR 1 Y74A , a mutant with impaired glutamate binding , and the activity of the heterodimer ( mutant / wild type ) was examined . ^^^ The half maximal dose of glutamate shifted from 1 . 3 ( wild type mGluR 1 ) to about 450 ( mGluR 1 Y74A ) microM . ^^^ Under these conditions , no glutamate mediated calcium current inhibition was observed below approximately 300 microM glutamate , although wild type mGluR 1 protein was detectable with immunofluorescence . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Antisense oligonucleotide against GTPase Rab5b inhibits metabotropic agonist DHPG induced neuroprotection . ( S ) 3 , 5 dihydroxyphenylglycine ( DHPG ) , a group 1 metabotropic glutamate receptor ( mGluR 1 and 5 ) agonist reduced NMDA mediated membrane currents , NMDA induced cell death and up regulated Rab5b , a small GTPase involved in endocytosis [ M . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Results obtained with a nitric oxide ( NO ) donor , NO synthase inhibitors , metabotropic glutamate receptor ( mGluR ) agonist and mGluR 1 antagonist , and a glial metabolism inhibitor suggest that after conditioning , presynaptic excitation is facilitated by NO released from glial cells via the activation of mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
LTDi involves a selective mGluR 1 ( metabotropic glutamate receptor 1 ) mediated calcium independent mechanism and the activation of the adenylyl cyclase protein kinase A pathway . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptors ( mGluR ) are implicated in long term memory storage . mGluR 1 and mGluR 2 antagonists impede various forms of learning and long term potentiation ( LTP ) in animals . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In cerebellar Purkinje cells , interaction of GABABR with extracellular Ca2+ ( Ca ( 2+ ) o ) leads to a constitutive increase in the glutamate sensitivity of metabotropic glutamate receptor 1 ( mGluR 1 ) . mGluR 1 sensitization is clearly mediated by GABABR because it is absent in GABABR 1 subunit knockout cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Abnormal L [ 3H ] glutamate specific binding to group 1 and 2 mGluRs , and abnormal mGluR 1 levels have been found in DLBD . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The antinociceptive and anxiolytic like effects of the metabotropic glutamate receptor 5 ( mGluR 5 ) antagonists , MPEP and MTEP , and the mGluR 1 antagonist , LY 456236 , in rodents : a comparison of efficacy and side effect profiles . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
After the establishment of operant ethanol self administration , subjects were treated with various metabotropic glutamate receptor ( mGluR ) subtype antagonists immediately prior to experimental sessions : the mGluR 5 antagonist MPEP ( 1 , 3 , and 10 mg / kg ) ; the mGluR 2 3 antagonist LY 341495 ( 1 , 3 , and 10 mg / kg ) ; and the mGluR 1 antagonist CPCCOEt ( 1 , 3 , and 10 mg / kg ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Pharmacological manipulation of metabotropic glutamate receptors mGluR 1 and 5 resulted in significant reduction of nerve cell susceptibility to NMDA induced injury , suggesting that these receptors may function as physiological regulators of neuronal vulnerability . cDNA microarray analysis of over 1000 brain related genes performed after the neuroprotective activation of group 1 metabotropic glutamate receptors ( mGluRs ) revealed a complex pattern of activation and inactivation of seemingly unrelated genes responsible for regulation of neuronal excitability , inflammation , cell death pathways , cell adhesion and transcriptional activation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
PFs stimulation activates metabotropic glutamate receptor subtype 1 ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here , using acute rat brain slices , we describe a form of long term depression ( LTD ) that was engaged by synaptic activity or exogenous agonists activating group 1 metabotropic glutamate receptors ( mGluR ) and was sensitive to mGluR 1 antagonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Synaptically released glutamate activated mGluR 1 receptors on amacrine cells and , depending on the strength of presynaptic activity , potentiated subsequent feedback . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The direct interaction between the GABA ( B ) receptor and the metabotropic glutamate receptor ( mGluR 1 ) has also attracted attention . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor type 1 ( mGluR 1 ) is thought to play important roles in the neurotransmission and pathogenesis of several neurological disorders . ^^^ YM 298198 inhibited glutamate induced inositol phosphate production in mGluR 1 NIH3T3 cells with an IC 50 of 16 + / 5 . 8 nM in a noncompetitive manner . ^^^ In ligand displacement experiments using rat cerebellum membrane , an existing noncompetitive mGluR 1 antagonist 7 ( hydroxyimino ) cyclo propa [ b ] chromen 1a carboxylate ethyl ester ( CPCCOEt ) competitively displaced [ 3H ] YM 298198 binding , although glutamate and other mGluR 1 ligands acting on a glutamate site failed to inhibit [ 3H ] YM 298198 binding , suggesting that YM 298198 binds to CPCCOEt ( allosteric ) binding sites but not to glutamate ( agonist ) binding sites . ^^^ Specificity was demonstrated for mGluR 1 over mGluR subtypes 2 to 7 , ionotropic glutamate receptors , and other receptor , transporter , and ion channel targets . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Modulatory action of metabotropic glutamate receptor ( mGluR ) 5 on mGluR 1 function in striatal cholinergic interneurons . ^^^ Within basal ganglia , group 1 metabotropic glutamate receptor subtypes ( mGluR 1 and 5 ) frequently co localize in the same neuron . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mGluR 1 , but not mGluR 5 , subclass of metabotropic glutamate receptors uses CK 1 to inhibit NMDA mediated synaptic currents . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have previously characterized a mouse melanoma model , TG 3 , which has implicated the ectopic expression of metabotropic glutamate receptor 1 ( Grm 1 , formerly mGluR 1 ) , in melanomagenesis and metastasis [ Pollock et al . , 2003 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors ( mGluR 1 ) regulate synaptic transmission through the stimulation of phospholipase Cbeta 1 ( PLCbeta 1 ) and then by the activation of protein kinase C ( PKC ) . ^^^ In contrast , L [ 3H ] glutamate specific binding to mGluRs is augmented in PiD cases , mainly because of the higher mGluR 1 and mGluRs expression levels detected . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The group 1 metabotropic glutamate receptor subtypes , mGluR 1 and mGluR 5 , have both distinct and overlapping actions in epileptogenesis . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
It was observed that MPEP ( selective for mGluR 5 subtype ) , failed to decrease endobain E response but reduced 50 60 % ouabain effect ; LY 367385 ( selective for mGluR 1 subtype ) and dizocilpine ( for ionotropic NMDA glutamate receptor ) did not reduce endobain E or ouabain effects . ^^^ These findings lead to suggest that endobain E effect on release is independent of metabotropic or ionotropic glutamate receptors , whereas that of ouabain involves mGluR 5 but not mGluR 1 receptor subtype . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Its similarity with the metabotropic glutamate mGluR 1 receptor allowed us to build homology models . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To elucidate the molecular determinants implicated in Ca ( 2+ ) recognition by the CaSR VFTM , we developed a homology model of the human CaSR VFTM from the 10 ray structure of the metabotropic glutamate receptor type 1 ( mGluR 1 ) , and a phylogenetic analysis of 14 class 3 GPCR VFTMs . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Electrophysiological responses of postsynaptic mGluR 1 in CF PC synapses could be obtained only with AMPA receptors blocked and glutamate uptake impaired . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Subtype selective noncompetitive modulators of metabotropic glutamate receptor subtype 1 ( mGluR 1 ) . ^^^ This article describes recent advances in the development of subtype selective , noncompetitive modulators of metabotropic glutamate receptor subtype 1 ( mGluR 1 ) . mGluR 1 plays an important role in modulating synaptic transmission and neuronal excitability via intracellular signal transduction pathways and has been implicated in a number of CNS disorders . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Under optimized docking conditions , glutamate was docked in the binding pocket of mGluR 1 with a root mean square deviation of 1 . 56 angstroms from the co crystallized glutamate structure and was ranked as the best ligand with a significantly better FlexX score compared to all other amino acids . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Endocannabinoid release and LTD induction both depend upon activation of the metabotropic glutamate receptor mGluR 1 , require postsynaptic calcium increases , are synapse specific , and have a similar dependence on the associative activation of PF and climbing fiber synapses . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 ( Grm 1 , formerly mGluR 1 ) is a G protein coupled receptor ( GPCR ) normally expressed and functional in the central nervous system . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
These electrophysiological data strongly indicate that the excitatory mechanism of pallidal neurons by glutamate is mediated at least partly through mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The group 1 metabotropic glutamate receptor ( mGluR ) subtype , mGluR 1 , is highly expressed on the apical dendrites of olfactory bulb mitral cells and thus may be activated by glutamate released from olfactory nerve ( ON ) terminals . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The localization of gold particles after immunostaining for astrocytic glutamate transporter ( GLAST ) , metabotropic glutamate receptor 1 ( mGluR 1 ) and neurofilament protein was consistent with previous reports and ultrastructure was well preserved in all cases . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor ( mGluR ) subtypes ( mGluR 1 to mGluR 8 ) act as important pre and postsynaptic regulators of neurotransmission in the CNS . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Although metabotropic glutamate receptors ( mGluRs ) mGluR 1 and mGluR 5 are often found to have similar functions , there is considerable evidence that the two receptors also serve distinct functions in neurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Bursts had a reversal potential near 0 mV , and were blocked by tetrodotoxin , the gap junction blocker carbenoxolone , or antagonists of AMPA , NMDA or mGluR 1 glutamate receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
MCs also express high levels of metabotropic glutamate receptor 1 ( mGluR 1 ) whose functional significance is less understood . ^^^ Here we characterized a slow mGluR 1 mediated potential that was evoked by high frequency ( 100 Hz ) olfactory nerve ( ON ) stimulation in the presence of NBQX and D APV , blockers of ionotropic glutamate receptors , and that was associated with a local Ca2+ transient in the MC dendritic tuft . ^^^ We conclude that the MC mGluR 1 potential triggered by glutamate released from the ON supports oscillations and synchronizations of MCs associated within one glomerulus . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The release evoked by NMDA / glycine / Tat depends on metabotropic glutamate receptor 1 ( mGluR 1 ) activation , since it was halved by mGluR 1 antagonists . ^^^ Tat seems to act at the glutamate recognition site of mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Type 1 metabotropic glutamate receptors ( mGluR 1 ) in Purkinje neurones ( PNs ) are important for motor learning and coordination . ^^^ Here , two divergent mGluR 1 Ca2+ signalling pathways and the associated membrane conductances were distinguished kinetically and pharmacologically after activation by 1 ms photorelease of L glutamate or by bursts of parallel fibre ( PF ) stimulation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The present study was devoted to investigate the effects of the metabotropic glutamate receptor ( mGluR ) 5 antagonist [ ( 2 methyl 1 , 3 thiazol 4 yl ) ethynyl ] pyridine ( MTEP ) and the mGluR 1 antagonist , ( 3 ethyl 2 methyl quinolin 6 yl ) ( 4 methoxy cyclohexyl ) methanone methanesulfonate ( EMQMCM ) , in animal studies indicative of antiparkinsonian like activity such as haloperidol induced catalepsy , hypoactivity in open field following haloperidol , and rotation in rats with unilateral 6 hydroxydopamine ( OHDA ) induced lesions of the midbrain dopaminergic system ( alone and in combination with L DOPA ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The analysis of the homology models of all possible dimers allowed by combinations of the human T1R2 and T1R3 sequences of the sweet receptor and the closed ( A ) and open ( B ) conformations of the mGluR 1 glutamate receptor shows that only ' type B ' sites , either T1R2 ( B ) and T1R3 ( B ) , can host the majority of small molecular weight sweeteners . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Although CDPPB is selective for mGluR 5 relative to other mGluR subtypes , several CDPPB analogs also showed 2 . 5 fold potentiation of glutamate induced calcium transients in cells expressing mGluR 1 at 10 muM , with 4 nitro N ( 1 , 4 diphenyl 1H pyrazol 5 yl ) benzamide ( VU 71 ) being selective for mGluR 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The influence of ions on agonist binding was examined in mGluR 1 , mGluR 3 , and mGluR 4 representing Group 1 , 2 , and 3 metabotropic glutamate receptors , respectively . [ ( 3 ) H ] Quisqualic acid binding to mGluR 1 required the presence of calcium ( or magnesium ) ions but not sodium or chloride ions while [ ( 3 ) H ] DCG 4 binding to mGluR 3 was dependent upon both cations and anions . [ ( 3 ) H ] L AP 4 binding to mGluR 4 required chloride ions but not monovalent or divalent cations . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We now report that activity of both Slo 2 channels is controlled by neuromodulators through Galphaq protein coupled receptors ( GqPCRs ) ( the M 1 muscarinic receptor and the mGluR 1 metabotropic glutamate receptor ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In THC tolerant mice , an increase of the basal release probability was found at PF PC synapses , in parallel with a facilitation of slow mGluR 1 ( metabotropic glutamate receptor type 1 ) mediated excitatory postsynaptic currents and a reduced sensitivity to the inhibitory effects of the CB1R agonist CP 55 , 940 [ ( ) cis 3 [ 2 hydroxy 4 ( 1 , 1 dimethylheptyl ) phenyl ] trans 4 ( 3 hydroxypropyl ) cyclohexanol ] . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Sustained activity of parallel fibers induces a form of long term depression that requires opening of calcium ( Ca ( 2+ ) ) permeable AMPA type glutamate receptors ( CP AMPARs ) and signaling through class 1 metabotropic glutamate receptors ( mGluR 1 ) and CB 1 receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Synaptic activation evokes local endocannabinoid release that relies on a pathway that involves the metabotropic glutamate receptor mGluR 1 and phospholipase C ( PLC ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have discovered a novel , potent , and selective triazafluorenone series of metabotropic glutamate receptor 1 ( mGluR 1 ) antagonists with efficacy in various rat pain models . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
It has recently been demonstrated that GABABR indeed modulates alpha amino 3 hydroxy 5 methyl 4 isoxalone propionate type ionotropic glutamate receptor ( AMPAR ) mediated and type 1 metabotropic glutamate receptor ( mGluR 1 ) mediated signaling . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Single label immunohistochemistry and double label immunofluorescence were used to study the expression of TRPC 1 among substantia nigra dopamine neurons and cellular processes using antibodies against tyrosine hydroxylase ( TH ) , substance P ( SP ) , enkephalin , synaptophysin , vesicular glutamate transporter 2 ( Vglut 2 ) , microtubule associated protein 2 and metabotropic glutamate receptor 1 ( mGluR 1 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We probed these libraries for expression of genes encoding the AMPA ( GluR 1 4 ) and kainate sensitive ( GluR 5 7 , KA 1 2 ) ionotropic glutamate receptors , the metabotropic glutamate receptors ( mGluR 1 8 ) , and five non vesicular glutamate transporters ( EAAT 1 5 ) in the macaque retina and brain and determined large portions of coding sequences for each . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Direct chemical activation of either NMDA or group 1 metabotropic glutamate receptor ( mGluR 1 ) elicits LTD of similar magnitudes , but it is unknown whether they share common expression mechanisms . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Agonist mediated phosphorylation of metabotropic glutamate receptor 1 alpha by protein kinase C in permanently transfected BHK cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Identification of the metabotropic glutamate receptor 1 protein in the rat trigeminal ganglion . ^^^ Anti metabotropic glutamate receptor 1 monoclonal antibody was raised and applied for immunohistochemistry in the rat trigeminal ganglion . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Inactivation in vivo of metabotropic glutamate receptor 1 by specific chromosomal insertion of reporter gene lacZ . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The second intracellular loop of metabotropic glutamate receptor 1 cooperates with the other intracellular domains to control coupling to G proteins . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Changes in the carboxyl terminal domain of metabotropic glutamate receptor 1 by alternative splicing generate receptors with differing agonist independent activity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Human metabotropic glutamate receptor 1 : mRNA distribution , chromosome localization and functional expression of two splice variants . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Evidence against a permissive role of the metabotropic glutamate receptor 1 in acute excitotoxicity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Three splice variants of the rat metabotropic glutamate receptor 1 ( mGlu1a , 1b and 1c receptors ) have been characterized so far . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To examine the translocation of gamma PKC GFP under physiological conditions , we expressed it in NG 108 cells , N methyl D aspartate ( NMDA ) receptor transfected COS 7 cells , or CHO cells expressing metabotropic glutamate receptor 1 ( CHO / mGluR1 cells ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A cluster of basic residues in the carboxyl terminal tail of the short metabotropic glutamate receptor 1 variants impairs their coupling to phospholipase C . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The mGlu receptor ligand ( S ) 4C3HPG protects neurons after global ischaemia in gerbils . ( S ) 4 Carboxy 3 hydroxy phenylglycine [ ( S ) 4C3HPG ] is a potent competitive antagonist at the metabotropic glutamate receptor 1 subtype ( mGlu 1 receptor ) and an agonist at mGlu2 / 3 receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Reduction of sensory and metabotropic glutamate receptor responses in the thalamus by the novel metabotropic glutamate receptor 1 selective antagonist S 2 methyl 4 carboxy phenylglycine . ^^^ Responses of thalamic neurons to noxious thermal somatosensory stimuli were reduced in parallel by these antagonists , indicating that these responses are mediated by Group 1 metabotropic glutamate receptors ( i . e . metabotropic glutamate receptor 1 and / or metabotropic glutamate receptor 5 ) , which are known to be linked to phosphoinositol phosphate hydrolysis . ^^^ The recent development of S 2 methyl 4 carboxyphenylglycine as an antagonist which is highly selective for metabotropic glutamate receptor 1 compared to metabotropic glutamate receptor 5 on human receptors expressed in AV 12 cells , now offers the possibility of discriminating between these two receptor subtypes in order to distinguish which is involved in thalamic responses . ^^^ These results suggest that excitatory responses of thalamic neurons to 1S , 3R aminocyclopentane 1 , 3 dicarboxylate and S 3 , 5 dihydroxyphenylglycine may be mediated by metabotropic glutamate receptor 1 . ^^^ Furthermore , the reduction of nociceptive responses by S 2 methyl 4 carboxy phenylglycine indicates that metabotropic glutamate receptor 1 is involved in thalamic nociceptive processing and that such antagonists may have analgesic properties . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Expression of metabotropic glutamate receptor 1 isoforms in the substantia nigra pars compacta of the rat . ^^^ Of the eight known metabotropic glutamate receptors , metabotropic glutamate receptor 1 is the most abundant subtype in the substantia nigra pars compacta . ^^^ Metabotropic glutamate receptor 1 is alternatively spliced at the carboxy terminal region to yield five variants : 1a , 1b , 1c , 1d and a form recently identified in human brain , 1g . ^^^ We used an antibody recognizing metabotropic glutamate receptor 1 , and another recognizing the splice form la only , to study the localization of these receptors in dopaminergic neurons identified by the presence of tyrosine hydroxylase . ^^^ The 1a splice form specific antibody , however , did not label these cells , suggesting that they express a metabotropic glutamate receptor 1 splice form different from 1a . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
CPCCOEt , a noncompetitive metabotropic glutamate receptor 1 antagonist , inhibits receptor signaling without affecting glutamate binding . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The effect of treatment with the D 1 dopamine receptor agonist SKF 38393 on the expression of metabotropic glutamate receptor 1 , 3 , 4 and 5 receptor subtypes and of the glutamate N methyl D aspartate ionotropic receptor subunits NRI , NR2A and NR2B was analysed using in situ hybridization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Three splice variants of the mouse metabotropic glutamate receptor 1 , mGluR1E55 , mGluR1a and mGluR1b , have been isolated from mouse brain cDNA libraries . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunolocalization of the mGluR1b splice variant of the metabotropic glutamate receptor 1 at parallel fiber Purkinje cell synapses in the rat cerebellar cortex . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This effect was counteracted by 1 aminoindan 1 , 5 dicarboxylic acid ( 100 microM ) , an antagonist of metabotropic glutamate receptor 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Assignment of the gene GRM 1 coding for metabotropic glutamate receptor 1 to human chromosome band 6q24 by in situ hybridization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The G protein coupled receptor kinase GRK 4 mediates homologous desensitization of metabotropic glutamate receptor 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Knockdown of spinal metabotropic glutamate receptor 1 ( mGluR ( 1 ) ) alleviates pain and restores opioid efficacy after nerve injury in rats . 1 . ^^^ With the aim of assessing its therapeutic potential , we examined the effect of antisense oligonucleotide knockdown of spinal metabotropic glutamate receptor 1 ( mGluR ( 1 ) ) in neuropathic rats . 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In double labeling experiments , most metabotropic glutamate receptor 1 positive cell bodies in the inner nuclear layer also label with anti GABA antibodies . ^^^ GABAergic amacrine cells in culture were also labeled by metabotropic glutamate receptor 1 and 5 antibodies . ^^^ Cytosolic Ca ( 2+ ) elevations were enhanced by metabotropic glutamate receptor 1 selective antagonists , suggesting that metabotropic glutamate receptor 1 activity might normally inhibit the Ca ( 2+ ) signaling activity of metabotropic glutamate receptor 5 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of metabotropic glutamate receptor 1 accelerates NMDA receptor trafficking . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of metabotropic glutamate receptor 1 inhibits glutamatergic transmission in the substantia nigra pars reticulata . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor 1 ( mGluR ( 1 ) ) plays a fundamental role in postnatal development and plasticity of ionotropic glutamate receptor mediated synaptic excitation of cerebellar Purkinje cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor 1 immunoreactive product was localized mostly in dendrites , while most of the metabotropic glutamate receptors 2 / 3 immunoreactive product was deposited in axon terminals containing synaptic vesicles of different shapes , suggesting that glutamate receptors 2 / 3 may control the release of both excitatory and inhibitory neurotransmitters . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here , we demonstrate that both the metabotropic gamma aminobutyric acid receptor B ( GABA ( B ) receptor ) and the metabotropic glutamate receptor 1 from rat cerebellum are insoluble in the non ionic detergent Triton 10 100 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Neither the metabotropic glutamate receptor 1 nor delta 2 glutamate receptor in flocculus and uvula / nodulus was affected by a hypergravity load for 2 h to 1 week . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Amino acid mutagenesis of the ligand binding site and the dimer interface of the metabotropic glutamate receptor 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Role of G protein coupled receptor kinase 4 and beta arrestin 1 in agonist stimulated metabotropic glutamate receptor 1 internalization and activation of mitogen activated protein kinases . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Physical mapping identified multiple tandem insertions of the transgene into intron 3 of Grm 1 ( encoding metabotropic glutamate receptor 1 ) with concomitant deletion of 70 kb of intronic sequence . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Atomic structures of the ligand binding core of the original metabotropic glutamate receptor 1 obtained using 10 ray crystallography provide a foundation for determining the initial receptor activation of this important family of G protein coupled receptors . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Unprecedented selectivity in trimethylenemethane cycloadditions with this building block allowed an efficient synthesis of a novel metabotropic glutamate receptor 1 antagonist in development by the Bayer corporation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Involvement of metabotropic glutamate receptor 1 , a G protein coupled receptor , in melanoma development . ^^^ This review focuses on the recent report of a mouse melanoma model , TG 3 , which has implicated the ectopic expression of the metabotropic glutamate receptor 1 ( Grm 1 ) , a G protein coupled receptor ( GPCR ) , in melanomagenesis and metastasis . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Pharmacological antagonism of metabotropic glutamate receptor 1 regulates long term potentiation and spatial reference memory in the dentate gyrus of freely moving rats via N methyl D aspartate and metabotropic glutamate receptor dependent mechanisms . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The astrocyte K+ current was dependent on AMPA and NMDA receptors in mitral / tufted cells as well as on a previously undescribed metabotropic glutamate receptor 1 component . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Phosphorylation independent regulation of metabotropic glutamate receptor 1 signaling requires g protein coupled receptor kinase 2 binding to the second intracellular loop . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The purpose of the present study was to compare anxiolytic activity of the metabotropic glutamate receptor 1 ( mGlu ) antagonist , EMQMCM ( ( 3 ethyl 2 methyl quinolin 6 yl ) ( 4 methoxy cyclohexyl ) methanone methanesulfonate ) and the mGlu 5 receptor antagonist MTEP ( [ ( 2 methyl 1 , 3 thiazol 4 yl ) ethynyl ] pyridine ) and MPEP ( 2 methyl 6 ( phenylethynyl ) pyridine ) in animal models of anxiety . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
CCL 2 increased resting Ca ( 2+ ) levels , enhanced the Ca ( 2+ ) response evoked by activation of metabotropic glutamate receptor 1 and depressed action potential generation in the cultured Purkinje neurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor 1 blockade impairs acquisition and retention in a spatial Water maze task . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Surface clustering of metabotropic glutamate receptor 1 induced by long Homer proteins . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We found that cultured melanocytes expressed the ionotropic glutamate receptors GluR 2 and 4 [ alpha amino 3 hydroxy 5 methyl 4 isoxsazolepropionic acid ( AMPA ) receptors ] and N methyl d aspartate ( NMDA ) receptors 2A and 2C and possibly the metabotropic glutamate receptor 1 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
However , the ligand specificity of each of the proposed umami receptors [ taste metabotropic glutamate receptor 4 , truncated metabotropic glutamate receptor 1 , or taste receptor 1 ( T1R1 ) and T1R3 dimers ] , taken alone , did not appear to explain the taste responses observed in mouse taste cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We discovered that aberrant expression of metabotropic glutamate receptor 1 ( Grm 1 ) in melanocytes promotes melanoma development in vivo . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We found that brief bursts of PF activity evoke calcium signals in BGs that are triggered by the activation of metabotropic glutamate receptor 1 and purinergic receptors and mediated by calcium release from IP 3 sensitive internal stores . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate receptor subtype genes ( gene symbol , GRM ) GRM 1 , GRM 2 , GRM 3 , GRM 4 , GRM 5 , and GRM 6 have been assigned to Chr 1 , 8 , 4 , 20 , 1 , and 10 , respectively . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Using a native chromatin immunoprecipitation assay , we studied histone methylation marks at proximal promoters of 16 ionotropic and metabotropic glutamate receptor genes ( GRIN 1 , 2A D ; GRIA 1 , 3 , 4 ; GRIK 2 , 4 , 5 ; GRM 1 , 3 , 4 , 6 , 7 ) in cerebellar cortex collected across a wide age range from midgestation to 90 years old . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
DL AP 3 antagonized mGlu 1 alpha and mGlu 5 responses , but antagonism was overcome at high glutamate concentrations consistent with competitive inhibition ( IC 50 = 2 . 1 mM for mGlu 1 alpha ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Cloned human metabotropic glutamate receptors , mGlu 1 alpha and mGlu 5 alpha , were functionally expressed in Xenopus oocytes . ^^^ Cyclothiazide dose dependently inhibited glutamate stimulated human mGlu 1 alpha responses ( IC 50 = 18 microM ) in a non competitive manner . ^^^ GYKI 52466 ( 1 ( 4 amino phenyl ) 4 methyl 7 , 8 methyl endioxyl 5H 2 , 3 benzodiazepinehydrochloride ) did not alter glutamate stimulated human mGlu 1 alpha or human mGlu 5 alpha responses , either in the presence or absence of cyclothiazide . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A novel splice variant , hmGlu1d , of the human mGlu 1 metabotropic glutamate receptor has been isolated from a human brain library . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A novel splice variant , hmGlu1d , of the human mGlu 1 metabotropic glutamate receptor has been isolated from a human brain library . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Pharmacological characterization of desensitization in a human mGlu 1 alpha expressing non neuronal cell line co transfected with a glutamate transporter . 1 . ^^^ Stimulation of phosphoinositide hydrolysis by human mGlu 1 alpha ( HmGlu 1 alpha ) was examined in a non neuronal cell line ( AV 12 664 ) co expressing both HmGlu 1 alpha and a rat glutamate / aspartate transporter ( GLAST ) . 2 . ^^^ These studies demonstrate desensitization of recombinant human mGlu 1 alpha receptor in a non neuronal cell line in which the receptor can be regulated by direct activation or by manipulation of glutamate transporter activity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The type 1 metabotropic glutamate receptor ( mGlu 1 ) messenger RNA and protein are known to be widely expressed in rat brain , but knowledge of the regional expression of splice variants other than mGlu1a is limited . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Finally , ( S ) ( + ) 2 ( 3 ' Carboxybicyclo [ 1 . 1 . 1 ] pentyl ) glycine ( UPF 596 ; 30 300 microM ) , a potent mGlu 1 antagonist with modest agonist activity on mGlu 5 , antagonised 1S , 3R ACPD induced glutamate release . ^^^ In conclusion , our data showed that 1S , 3R ACPD induced glutamate release in the parietal cortex is mediated by mGlu 1 receptors and that , under basal conditions , these receptors are not tonically activated . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have studied the effects in three rodent models of generalised convulsive or absence epilepsy of two antagonists of group 1 metabotropic glutamate receptors that are selective for the mGlu 1 receptor . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Glutamate , the principal excitatory neurotransmitter in the brain , acts on three families of ionotropic receptor AMPA ( alpha amino 3 hydroxy 5 methyl isoxazole 4 propionic acid ) , kainate and NMDA ( N methyl D aspartate ) receptors and three families of metabotropic receptor ( Group 1 : mGlu 1 and mGlu 5 ; Group 2 : mGlu 2 and mGlu 3 ; Group 3 : mGlu 4 , mGlu 6 , mGlu 7 and mGlu 8 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The role of group 1 metabotropic glutamate receptors ( mGlu 1 and 5 ) in neurodegeneration is still controversial . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In order to study the role of metabotropic glutamate 1 ( mGlu 1 ) receptors in ischemic neuronal death , we examined the effects of the recently characterized and relatively selective mGlu 1 receptor antagonists 1 aminoindan 1 , 5 dicarboxylic acid ( AIDA ) and ( S ) ( + ) 2 ( 3 ' carboxybicyclo [ 1 . 1 . 1 ] pentyl ) glycine ( CBPG ) in murine cortical cell cultures and rat organotypic hippocampal slices exposed to oxygen glucose deprivation ( OGD ) and in vivo , following transient global ischemia in gerbils . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
On the basis of a new sequence alignment between the amino terminal domains of mGlu 1 and mGlu 5 receptor subtypes and leucine / isoleucine / valine binding protein ( LIVBP ) , three dimensional models of the binding sites of the two group 1 metabotropic glutamate receptor subtypes were constructed . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
RT PCR combined with immunoblotting showed the expression of group 1 ( mGlu 1 and 5 ) and group 2 ( mGlu 2 and 3 ) metabotropic glutamate receptors in whole mouse thymus , isolated thymocytes and TC 1S thymic stromal cell line . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The nociceptive responses of rat ventrobasal thalamus neurons can be reduced by N methyl D aspartate antagonists and by selective metabotropic glutamate receptor mGlu 1 antagonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Synaptic activation of the group 1 metabotropic glutamate receptor mGlu 1 on the thalamocortical neurons of the rat dorsal lateral geniculate nucleus in vitro . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
It is known that metabotropic glutamate receptors of the subtypes mGlu 1 and mGlu 5 participate in nociceptive processing in the thalamus , an area of prime importance in supra spinal sensory processing . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of group 1 metabotropic glutamate receptors ( mGlu 1 or 5 receptors ) is known to either enhance or attenuate excitotoxic neuronal death depending on the experimental conditions . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Selective antagonists of mGlu 1 ( LY 367385 and CPCCOEt ) and mGlu 5 ( MPEP ) metabotropic glutamate receptors were neuroprotective against NMDA toxicity when either applied to mixed cortical cultures or locally infused into the caudate nucleus . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Finally , because metabotropic glutamate ( mGlu ) receptors modulate transmitter release in striatal preparations , we evaluated , with negative results , kynurenic acid ( 1 100 nM ) effects in cells transfected with mGlu 1 , mGlu 2 , mGlu 4 or mGlu 5 receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have applied subtype selective antagonists of metabotropic glutamate ( mGlu ) receptors mGlu 1 or mGlu 5 [ 7 ( hydroxy imino ) cyclopropa [ b ] chromen 1a carboxylate ethyl ester ( CPCCOEt ) or 2 methyl 6 ( phenylethynyl ) pyridine ( MPEP ) ] to mixed rat cerebellar cultures containing both Purkinje and granule cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We have identified two chemical series of compounds acting as selective positive allosteric modulators ( enhancers ) of native and recombinant metabotropic glutamate 1 ( mGlu 1 ) receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate mGlu 1 receptor mRNA expression in dorsal root ganglia of rats after peripheral nerve injury . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Recent drug discovery programs aimed at identifying selective metabotropic mGlu receptor ligands by high throughput functional screening efforts have revealed subtype selective allosteric modulators of mGlu 1 and mGlu 5 receptors that are structurally unrelated to glutamate . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Pre exposure of hmGlu1a receptor expressing cells to the mGlu 1 receptor antagonists ( S ) 4 carboxy 3 hydroxyphenylglycine and 7 ( hydroxyimino ) cyclo propa [ b ] chromen 1a carboxylate ethyl ester dramatically enhanced subsequent glutamate induced phosphoinositide hydrolysis and intracellular [ Ca ( 2+ ) ] rise . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The novel and systemically active metabotropic glutamate 1 ( mGlu 1 ) receptor antagonist 3 MATIDA reduces post ischemic neuronal death . ^^^ We examined the pharmacological properties of 3 methyl aminothiophene dicarboxylic acid ( 3 MATIDA ) by measuring second messenger responses in baby hamster kidney cells stably transfected with mGlu1a , mGlu 2 , mGlu4a or mGlu5a receptors and ionotropic glutamate receptor agonist induced depolarizations in mouse cortical wedges . 3 MATIDA was a potent ( IC ( 50 ) =6 . 3 microM , 95 % confidence limits 3 15 ) and relatively selective mGlu 1 receptor antagonist . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Several potent and group selective agonists of metabotropic glutamate receptors ( mGluRs ) have been docked at mGlu 1 , 2 , 4R binding sites in the closed conformation of the bilobate extracellular domain . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Activation of mGlu 1 but not mGlu 5 metabotropic glutamate receptors contributes to postischemic neuronal injury in vitro and in vivo . ^^^ In order to investigate the involvement of mGlu 1 and mGlu 5 metabotropic glutamate receptors in the development of postischemic neuronal death , we examined the effects of selective agonists and antagonists in models of cerebral ischemia in vitro and in vivo . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Recently , the structure of the dimer of mGlu 1 VFTMs revealed two important conformational changes resulting from glutamate binding . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We demonstrated previously that the group 1 metabotropic glutamate receptors ( mGluRs ) mGlu 1 and mGlu 5 are expressed in the peripheral terminals of sensory neurons and that activation of group 1 mGluRs in the skin increases thermal sensitivity . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Metabotropic glutamate 1 ( mGlu 1 ) receptor antagonists enhance GABAergic neurotransmission : a mechanism for the attenuation of post ischemic injury and epileptiform activity . ^^^ Selective antagonists of mGlu 1 metabotropic glutamate receptors attenuate neuronal death in models of cerebral ischemia . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
R 214127 was shown to be a potent and noncompetitive metabotropic glutamate 1 ( mGlu 1 ) receptor selective antagonist . ^^^ Inhibition experiments showed that [ ( 3 ) H ] R 214127 binding was completely blocked by 2 quinoxaline carboxamide N adamantan 1 yl ( NPS 2390 ) , ( 3aS , 6aS ) 6a naphtalan 2 ylmethyl 5 methyliden hexahydro cyclopenta [ c ] furan 1 on ( BAY 36 7620 ) , and 7 ( hydroxyimino ) cyclo propa [ b ] chromen 1a carboxylate ethyl ester ( CPCCOEt ) , but was not displaced by competitive mGlu 1 receptor ligands such as glutamate and quisqualate , suggesting that R 214127 , NPS 2390 , BAY 36 7620 , and CPCCOEt bind to the same site or mutually exclusive sites . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In motoneurons in spinal cord slices the activation of group 1 metabotropic glutamate ( mGlu 1 ) receptors leads to facilitation of CaV1 . 3 L type calcium channels . ^^^ We conclude that glutamate released during spinal motor network activity excites motoneurons by parallel activation of ionotropic and mGlu 1 receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In a three dimensional model of the NR2B LIVBP like domain based on the 10 ray crystal structure of the amino terminal domain of the mGlu 1 receptor , the critical residues are located in the central cleft where interaction with RO 25 6981 may stabilize the closed structure of the domain . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We used the selective metabotropic glutamate ( mGlu ) 1 receptor antagonist [ 3H ] 1 ( 3 , 4 dihydro 2H pyrano [ 2 , 3 b ] quinolin 7 yl ) 2 phenyl 1 ethanone ( [ 3H ] R 214127 ) to investigate the distribution of mGlu 1 receptor binding sites in rat brain . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Selective antagonists of mGlu 1 , mGlu 5 , NMDA and NR2B subunit containing NMDA glutamate receptors , as well as NK 1 , and NK 3 receptors , and a non selective blocker of all tachykinin receptors , were assessed for their effects on the magnitude and duration of the increase in reflexes induced by mustard oil . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Effects of mGlu 1 and mGlu 5 metabotropic glutamate antagonists to reverse morphine tolerance in mice . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Allosteric modulators of metabotropic glutamate receptors : lessons learnt from mGlu 1 , mGlu 2 and mGlu 5 potentiators and antagonists . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Second , two CaR mGlu chimeric receptor constructs that retained the VFT domain of CaR , one containing the extracellular Cys rich region of CaR and the other containing the Cys rich region of the rat metabotropic glutamate type 1 ( mGlu 1 ) receptor , together with the rat mGlu 1 transmembrane region and C terminal tail , retained amino acid sensing . ^^^ The findings support the concept that the mGlu 1 amino acid binding site for L glutamate is conserved as an L amino acid binding site in its homolog , the CaR . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
RATIONALE : Group 1 metabotropic glutamate receptor antagonists , which block both the mGlu 1 and mGlu 5 receptors , have been shown to have anxiolytic effects in the lick suppression test in rats . ^^^ CONCLUSION : Our data suggest that the anxiolytic like effects induced by group 1 metabotropic glutamate receptor antagonists are mediated through both mGlu 1 and mGlu 5 receptors . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
T 7 ( hydroxyimino ) cyclopropa [ b ] chromen 1alpha carboxylate ethyl ester ( CPCOOE / 50 nmol / rat ) and ( S ) ( + ) alpha amino 4 carboxy 2 methylbenzeneacetic acid ( LY 367385 , 20 nmol / rat ) , selective mGlu 1 glutamate receptor antagonists , were ineffective in preventing the WIN induced effects . ^^^ Moreover , the physiological stimulation of PAG mGlu 5 , but not mGlu 1 glutamate receptors , seems to be required for the cannabinoid mediated effect . . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Several lines of evidence suggest that mGlu 1 metabotropic glutamate receptors may be involved in seizure disorders such as epilepsy . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Group 1 metabotropic glutamate receptors stimulate the activity of poly ( ADP ribose ) polymerase in mammalian mGlu 1 transfected cells and in cortical cell cultures . ^^^ Group 1 metabotropic glutamate ( mGlu ) receptors ( i . e . mGlu 1 and mGlu 5 ) coupled to phospholipase C have been widely investigated for their possible role in excitotoxic and post ischemic neuronal death . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A selective metabotropic glutamate 1 receptor ( mGlu 1 ) antagonist was labeled with the positron emitting radioisotope carbon 11 and evaluated in ex vivo biodistribution studies and micro positron emission tomography ( micro PET ) imaging experiments in rats . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Post anoxic rats showed a reduction in the expression of group 1 metabotropic glutamate receptors ( i . e . mGlu 1 and mGlu 5 receptors ) in the hippocampus and cerebral cortex , whereas expression of the mGlu 2 / 3 receptors , the NR 1 subunit of NMDA receptors , and the GluR 1 subunit of alpha amino 3 hydroxy 5 methylisoxazole 4 propionate ( AMPA ) receptors was unchanged . mGlu 1 and mGlu 5 receptor signalling was also impaired in postanoxic rats , as revealed by a reduced efficacy of the agonist ( 1S , 3R ) 1 Aminocyclopentane 1 , 3 dicarboxylic acid ( 1S , 3R ACPD ) to stimulate polyphosphoinositide hydrolysis in hippocampal slices . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate ( mGlu ) receptors mGlu 1 and mGlu 5 mediate distinct inositol 1 , 4 , 5 trisphosphate ( IP ( 3 ) ) and Ca ( 2+ ) signaling patterns , governed in part by differential mechanisms of feedback regulation after activation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Effects of bromohomoibotenate on metabotropic glutamate receptors . ( S ) Bromohomoibotenic acid [ ( S ) BrHIbo ] stereoselectively antagonized glutamate stimulated phosphoinositide ( PI ) hydrolysis in baby hamster kidney ( BHK ) cells expressing mGluR1a in a competitive manner with an IC 50 of 250 microM . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
L glutamate uptake inhibitors may stimulate phosphoinositide hydrolysis in baby hamster kidney cells expressing mGluR1a via heteroexchange with L glutamate without direct activation of mGluR1a . ^^^ The functional efficacies of inhibitors of L glutamate uptake for altering second messenger formation in baby hamster kidney cells expressing subtypes mGluR1a , mGluR 2 , and mGluR 4 of the metabotropic glutamate receptor family were examined . ^^^ L Cysteine sulfinate , 1 aminocyclobutane trans 1 , 3 dicarboxylate , L cysteine , and DL threo 3 methylaspartate stimulated phosphoinositide hydrolysis in mGluR1a cells with EC 50 values of 43 , 64 , 463 , and 488 microM , respectively , and displaced L [ 3H ] glutamate binding from membranes prepared from these cells with respective IC 50 values of 48 , 44 , 79 , and 139 microM . ^^^ However , D aspartate , L trans pyrrolidine 2 , 4 dicarboxylate , L threo 3 hydroxyaspartate , and L aspartate beta hydroxamate stimulated phosphoinositide hydrolysis in mGluR1a cells ( respective EC 50 values of 73 , 54 , 57 , and 430 microM ) but did not displace L [ 3H ] glutamate binding . ^^^ These compounds inhibited Na ( + ) dependent L glutamate uptake into baby hamster kidney cells with IC 50 values similar to those for stimulation of phosphoinositide hydrolysis in mGluR1a cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The shortened mRNA , revealed in the clone , apparently encoded a functional mGluR that was sensitive to glutamate , but unlike the mGluR1a , it did not respond to 1S , 3R ACPD ( 1S , 3R aminocyclopentane 1 , 3 dicarboxylic acid ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Polyamines modulate the function of transfected glutamate receptor mGluR1a . ^^^ Metabotropic glutamate receptor mGluR1a was expressed in human embryonic kidney 293 cells . 1S , 3R aminocyclopentane 1 , 3 dicarboxylic acid ( 1S , 3R ACPD ) stimulated dose dependently , phosphoinositide ( PI ) hydrolysis in transfected , but not in non transfected cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The pharmacological profile of ( 2S , 1 ' S , 2 ' S , 3 ' R ) 2 ( 2 ' Carboxy 3 ' phenylcyclopropyl ) glycine ( PCCG 4 ) at metabotropic glutamate receptor ( mGluR ) subtypes mGluR1a , mGluR 2 , mGluR4a , and mGluR 5 was examined . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunocytochemical visualization of the mGluR1a metabotropic glutamate receptor at synapses of corticothalamic terminals originating from area 17 of the rat . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The coupling of subtype mGluR1a of the metabotropic glutamate receptor family to phosphoinositide hydrolysis , cAMP formation and arachidonic acid release was characterized when the receptor was expressed in baby hamster kidney ( BHK ) cells . 2 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunocytochemical localization of mGluR1a metabotropic glutamate receptor in inhibitory interneurons of the cerebellar cortex . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In cells transfected with mGluR1a , AIDA competitively antagonized the stimulatory responses of glutamate and ( 1S , 3R ) 1 aminocyclopentane 1 , 3 dicarboxylic acid [ ( 1S , 3R ) ACPD ] on phosphoinositide hydrolysis ( pA 2 = 4 . 21 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we describe changes in metabotropic glutamate receptor 1a ( mGluR1a ) immunoreactivity 3 , 7 or 14 days after unilateral aciatic transection . mGluR1a immunoreactivity was distributed throughout the somatic cytoplasm and somatodendritic membrane of uninjured motoneurons and was significantly reduced in axotomized motoneurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptor type 1a ( mGluR1a ) is expressed at a high level in the molecular layer of the cerebellar cortex , where it is localized mostly in dendritic spines of Purkinje cells , innervated by parallel fibers . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Immunohistochemical localization of metabotropic glutamate receptors mGluR1a and mGluR2 / 3 in the rat basal ganglia . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Two color immunofluorescence histochemistry and immunohistochemistry in combination with retrograde tract tracing techniques were used to examine the distribution of metabotropic glutamate receptor subtypes 1a and 5 ( mGluR1a and mGluR 5 ) among identified subpopulations of striatal projection neurons and interneurons . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Significantly , these compounds did not affect responses elicited by the homologous metabotropic glutamate receptors , mGluR1a , mGluR 2 , or mGluR 8 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Differential localisation of the metabotropic glutamate receptor mGluR1a and the ionotropic glutamate receptor GluR2 / 3 in neurons of the human cerebral cortex . ^^^ Specimens of human cerebral cortex were obtained during neurosurgical operations and studied by immunocytochemistry and electron microscopy , using antibodies to the metabotropic glutamate receptor subunit mGluR1a and the ionotropic glutamate receptor GluR2 / 3 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
We show here that metabotropic glutamate receptors are differentially targeted when expressed from defective viral vectors in cultured hippocampal neurons ; mGluR1a and mGluR 2 are targeted to dendrites and excluded from axons , whereas mGluR 7 is targeted to axons and dendrites . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In this study , Chinese hamster ovary ( CHO ) cells permanently transfected with rat mGluR1a , mGluR 2 and mGluR 4 were employed as a model to examine the activation of MAPK by glutamate through mGluRs . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
A light and electron microscopic study of the metabotropic glutamate receptor mGluR1a in the normal and kainate lesioned rat hippocampus . ^^^ The distribution of the metabotropic glutamate receptor mGluR1a was studied in the normal and kainate lesioned rat hippocampus using a monoclonal ( MAb ) and a polyclonal antibody to mGluR1a . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The effect of chronic imipramine ( IMI ) or electroconvulsive shock ( ECS ) treatment on the expression of group Ia metabotropic glutamate receptors ( mGluR1a ) was studied in the rat hippocampus by an immunohistochemical method , using a specific monoclonal antibody . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
This constitutive activity was not diminished when the mutations were transferred to a chimeric receptor Ca / 1a consisting of the amino terminal domain of the CaR and the 7 transmembrane and intracellular domains of the metabotropic glutamate receptor mGluR1a . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The postnatal developmental distribution pattern of metabotropic glutamate receptor ( mGluR1a ) immunoreactive unipolar brush cells ( UBCs ) was studied in the cerebellar cortex of kittens . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The effects of axotomy or TTX block on motoneuron expression of the metabotropic glutamate receptor mGluR1a were also studied . mGluR1a ir was also strongly decreased after axotomy but not after TTX treatment . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The distribution of glutamate receptors in the monkey subthalamic nucleus was studied using affinity purified polyclonal antibodies to GluR 1 , phosphorylated GluR 1 , GluR2 / 3 , NMDAR 1 , mGluR1a and mGluR 5 . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Such agonist independent ( constitutive ) activity has been observed for the glutamate GPCRs ( the metabotropic glutamate receptors mGluR1a and mGluR 5 ) when they are overexpressed in heterologous cells . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate receptors ( mGluR ) , mGluR1a and mGluR5a , are G protein coupled receptors that couple via G ( q ) to the hydrolysis of phosphoinositides , the release of Ca ( 2+ ) from intracellular stores , and the activation of protein kinase C ( PKC ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Following stimulation with glutamate ( 10 microM ; 30 min ) the HA mGluR1a underwent internalization to endosomes . ^^^ Expression of either dominant negative mutant constructs with receptor strongly inhibited glutamate induced ( 10 microM ; 30 min ) HA mGluR1a internalization . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Three Homer genes regulate the activity of metabotropic glutamate receptors mGluR1a and mGluR 5 and their coupling to releasable intracellular Ca2+ pools and ion channels . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we show , however , that by activating the metabotropic glutamate receptor ( mGluR ) , mGluR1a , cortical inputs can recruit intricate cellular mechanisms that enable the generation of an intrinsic slow oscillation in TC neurons in vitro with identical properties to those observed in vivo . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In the present study , a single and double immunohistochemical staining techniques were used in order to visualize CRF , NPY and metabotropic glutamate receptors ( mGluR1a ) in rat amygdala . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
For this purpose , we expressed in HeLa cells aequorin based Ca ( 2+ ) sensitive probes targeted to different intracellular compartments and studied the effect of two agonists : histamine , acting on endogenous H ( 1 ) receptors , and glutamate , acting on co transfected metabotropic glutamate receptor ( mGluR1a ) , which rapidly inactivates through protein kinase C dependent phosphorylation and thus causes transient inositol 1 , 4 , 5 trisphosphate production . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Therefore , we used immunocytochemistry to examine the effect of unilateral 6 hydroxydopamine lesions of SNc on the expression of metabotropic glutamate receptors ( mGluR1a , 2 / 3 , 5 , 4 , 8 ) and tyrosine hydroxylase ( TH ) . 6 Hydroxydopamine causes a fall in the number of mGluRs and TH in the lesioned lateral substantia nigra . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Here we show that , in slices of the lateral geniculate nucleus maintained in vitro , activation of the metabotropic glutamate receptor ( mGluR ) mGluR1a induces synchronized oscillations at alpha and theta frequencies that share similarities with thalamic alpha and theta rhythms recorded in vivo . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
All three antagonists inhibited glutamate induced internalization of mGluR1a and mGluR1b . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Seven in absentia homolog 1A ( Siah1A ) is a member of the RING finger containing E 3 ubiquitin ligases and has been shown to bind to the Siah interacting domain ( SID ) at the carboxyl terminal tails of the long splice forms of group 1 metabotropic glutamate receptors ( mGluR1a and mGluR 5 ) . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
To characterize the developmental changes in the substantia nigra pars reticulata ( SNr ) associated with the expression of group 1 metabotropic glutamate receptors ( mGluRs ) , we used the immunoperoxidase and immunogold methods at the electron microscope level to determine whether the subcellular and subsynaptic patterns of distribution of mGluR1a and mGluR 5 differ between young ( P 14 P18 ) and adult ( > 2 months ) rats . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
Class 1 metabotropic glutamate receptors ( mGluRs ) mGluR1a and mGluR5a , which are coupled with the hydrolysis of phosphoinositides , are essential for modulating excitatory neurotransmission at glutamatergic synapses . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
O / A cells can also coexpress CP AMPARs , Ca2+ impermeable AMPARs ( CI AMPARs ) , and group I / II metabotropic glutamate receptors ( mGluRs ) ( including mGluR1a ) , in the same cell . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The constitutive internalization of metabotropic glutamate receptor 1a ( mGluR1a ) has been described , but in general little attention has been dedicated to this important aspect of receptor regulation . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
In oocytes co injected with mRNA for GirK 2 and the mGluR1a metabotropic receptor , exposure to glutamate potentiated currents evoked by a high potassium solution . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The metabotropic glutamate G protein coupled receptors mGluR 3 and mGluR1a are voltage sensitive . ^^^ Here we examine whether two metabotropic glutamate receptors , mGluR 3 and mGluR1a , both involved in fundamental physiological processes , exhibit , by themselves , voltage sensitivity . ^^^ Measuring mGluR 3 induced K ( + ) currents and mGluR1a induced Ca ( 2+ ) activated Cl ( ) currents in Xenopus oocytes , we show that the apparent affinity toward glutamate decreases ( mGluR 3 ) or increases ( mGluR1a ) upon depolarization . ^^^ Measurements of binding of [ ( 3 ) H ] glutamate to oocytes expressing either mGluR 3 or mGluR1a corroborated the electrophysiological results . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
The role of protein interaction motifs in regulating the polarity and clustering of the metabotropic glutamate receptor mGluR1a . ^^^ When expressed in cultured hippocampal neurons , the metabotropic glutamate receptor mGluR1a is polarized to dendrites and concentrated at postsynaptic sites . ^^^
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
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Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA
Interacting proteins: Q13255 and Q13224	Pubmed	SVM Score :0.0
NA