| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Functional expression and pharmacological characterization of the human EAA 4 ( GluR 6 ) glutamate receptor : a kainate selective channel subunit . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In contrast , the oocytes injected with RNAs for AMPA selective glutamate receptors ( GluR 1 , GluR 3 , GluR1+GluR2 and GluR2+GluR3 ) scarcely responded to NAAG , and the oocytes injected with RNA for kainate receptor ( GluR 6 ) did not respond to NAAG . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our data show that the GluR 6 and GluR 7 subunits have a rank order of agonist affinity ( domoate greater than kainate much greater than L glutamate , quisqualate much greater than AMPA , NMDA ) and a dissociation constant for kainate ( 95 and 77 nM , respectively ) characteristic of the low affinity kainate binding sites described in the brain . . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here we report the cloning and expression of a functional rat glutamate receptor subunit cDNA , GluR 6 , which has a very different pharmacology from that of the GluR 1 GluR4 class . ^^^ When expressed in Xenopus oocytes the homomeric GluR 6 receptor is activated by kainate , quisqualate and L glutamate but not by AMPA , and the apparent affinity for kainate is higher than for receptors from the GluR 1 GluR4 class . ^^^ The homomeric GluR 6 glutamate receptor exhibits an outwardly rectifying current voltage relationship . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This property and our present observation together suggest that the glutamate receptors previously studied electrophysiologically by others in horizontal cells may contain GluR 6 . mGluR 1 alpha is found mostly in the inner plexiform layer ; its localization partially overlaps with that of the inositol trisphosphate receptor in the retina . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our results provide evidence for the existence of functional glutamate receptors of the kainate type in nerve cells , which are likely to be native homomeric GluR 6 receptors . . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We now show by reverse transcriptase polymerase chain reaction and Southern blotting that these neurons transcribe each of the nine known non NMDA glutamate receptor genes ( GluR 1 7 , Ka 1 , and Ka 2 ) and that four of these genes ( GluR 2 , GluR 6 , GluR 7 , and Ka 1 ) are also transcribed by undifferentiated NT 2 cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RNA editing and subunit assembly of ionotropic glutamate receptors ( GluRs ) were examined in an oligodendrocyte progenitor cell line , CG 4 , which expresses GluR 2 GluR4 , GluR 6 , GluR 7 , KA 1 , and KA 2 . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RNA editing of the glutamate receptor subunits GluR 2 and GluR 6 in human brain tissue . ^^^ Editing of mRNA in the coding region of the second transmembrane domain of glutamate receptor subunits GluR 2 , GluR 5 , and GluR 6 involves a change of the base A in genomic DNA to the base G in mRNA as described in rat brain . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| By exchanging portions of the AMPA receptor subunit GluR 3 and the kainate receptor subunit GluR 6 , we have identified two discontinuous segments of approximately 150 amino acid residues each that control the agonist pharmacology of these glutamate receptors . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Stable expression of a functional GluR 6 homomeric glutamate receptor channel in mammalian cells . ^^^ The kainate selective glutamate receptor GluR 6 was constitutively expressed under the control of a metallothionein promoter . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , using the whole cell patch clamp recording technique , we have shown that phosphorylation at this site increases the amplitude of the GluR 6 mediated glutamate current without significantly altering its dose response , current voltage relation or desensitization kinetics . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The structure and function of glutamate receptor subunits GluR 2 , GluR 5 , and GluR 6 are changed by RNA editing . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The importance of two specific domains in ligand binding to the AMPA / kainate glutamate receptors GluR 2 and GluR 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Ca2+ permeability of unedited and edited versions of the kainate selective glutamate receptor GluR 6 . ^^^ The Ca2+ permeability of the kainate selective glutamate receptor GluR 6 depends on the editing of the RNA ( or DNA ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Regional differences in the extent of RNA editing of the glutamate receptor subunits GluR 2 and GluR 6 in rat brain . ^^^ The extent of RNA editing of the glutamate receptor subunits GluR 2 and GluR 6 was studied by using a newly developed method based on the restriction analysis of the subunit specific polymerase chain reaction ( PCR ) product with the enzyme Bbv 1 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To determine the distributions of glutamate receptors throughout the macaque hypothalamus , we utilized highly specific antipeptide antibodies to visualize alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate receptor subunits ( GluR 1 , GluR 2 and GluR 3 [ designated as GluR2 / 3 ] , and GluR 4 ) ; kainate receptor subunits ( GluR 6 and GluR 7 , [ designated as GluR6 / 7 ] ) , and a metabotropic receptor ( mGluR 1 alpha ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The dopamine D 3 receptor was stably expressed in GH 3 cells , and GluR 6 ( a glutamate receptor subunit ) was stably expressed in human embryonic kidney ( HEK 293 ) cells . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| At a moderate level were GluR 6 , NR2B , and NR2D . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An ionotropic glutamate receptor of the kainate subtype ( GluR 6 ) and a G protein coupled metabotropic glutamate receptor ( mGluR 1 alpha ) were expressed and studied in two insect cell lines : sf 9 cells from Spodoptera frugiperda and MG 1 cells from Trichoplusia ni . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The expression patterns of nine genes encoding the N methyl D aspartate ( NMDA ) receptor subunits NR 1 and NR2A , NR2B , NR2C and NR2D , and the high affinity kainate receptor subunits KA 1 , KA 2 , GluR 6 and GluR 7 , were studied in the adult rat retina by in situ hybridization . ^^^ Hybridization with [ 35S ] dATP labelled oligonucleotide probes revealed the expression of four of the NMDA receptor subunits ( NR 1 , NR2A , NR2B and NR2C ) and three of the high affinity kainate receptor subunits ( KA 2 , GluR 6 and GluR 7 ) in the retina . ^^^ The GluR 6 , NR2A , NR2B and NR2C subunits were expressed by subsets of amacrine cells . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Because neuropathological states and possibly human disorders may involve kainate preferring glutamate receptors , we have isolated a cDNA clone for the human GluR 6 kainate preferring receptor . ^^^ When the protein was overexpressed in human embryonic kidney 293 cells , it had a molecular weight , an antibody recognition , and a glutamate ligand binding profile similar to those of the rat GluR 6 receptor . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation and modulation of recombinant GluR 6 glutamate receptors by cAMP dependent protein kinase . ^^^ Here we report that the GluR 6 glutamate receptor , transiently expressed in mammalian cells , is directly phosphorylated by PKA , and that intracellularly applied PKA increases the amplitude of the glutamate response . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The effect of protein kinase C ( PKC ) activation on maximal kainate ( KA ) induced currents was studied in Xenopus oocytes expressing the glutamate receptor ( GluR ) subunits GluR 3 , GluR 1 + 3 , GluR 2 + 3 , and GluR 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| GluR 6 is a glutamate receptor of the kainate subtype that is expressed in the mammalian central nervous system . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Polymerase chain reaction studies showed that the glutamate receptor subunits GluR 1 4 and GluR 6 were all expressed in these cultures , but GluR 5 was absent . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Transmembrane topology of the glutamate receptor subunit GluR 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , the sites of N linked oligosaccharides on GluR 6 , a member of the kainate class of ionotropic glutamate receptors , were examined . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NR2A , NR2B , and GluR 6 mRNAs were undetectable . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Expression and novel subunit isoforms of glutamate receptor genes GluR 5 and GluR 6 . ^^^ Molecular heterogeneity of kainate selective glutamate receptor subunits GluR 5 and GluR 6 was revealed by identification of a human cDNA , GluR 5 1d , and a murine cDNA , GluR 6 2 , that each encode subunits with novel carboxy terminal sequences . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The following transcripts were detected : at least one member of the GluR 1 4 family , GluR 5 , GluR 6 , GluR 7 , KA 1 , KA 2 , NMDAR 1 , and NMDAR2B . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To examine subunit assembly and biochemical properties of two members of the kainate family of glutamate receptors ( GluR ) , antibodies were made to synthetic peptides corresponding to the carboxyl termini of GluR 6 and KA 2 . ^^^ Immunoblot analysis of membranes from human embryonic kidney cells transfected with glutamate receptor cDNAs showed that these antibodies are selective for their respective receptor subunit except that the antibody to GluR 6 also recognizes GluR 7 , which is expected due to the sequence homology between the two subunits at the carboxyl terminus . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The functional modulation of GluR 6 , a kainate activated glutamate receptor , by adenosine 3 ' , 5 ' monophosphate dependent protein kinase A ( PKA ) was examined with receptors expressed in human embryonic kidney cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Loss of CA 3 and hilar neurons was also induced by transducing organotypic hippocampal slice cultures with a replication defective herpes simplex virus ( HSV ) vector expressing the GluR 6 kainate subtype of the glutamate receptor ( HSVGluR 6 ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Further characterization of the murine glutamate receptor family includes mapping of Glur 1 to the same region as neurological mutants spasmodic , shaker 2 , tipsy , and vibrator on chromosome 11 ; Glur 2 near spastic on chromosome 3 ; Glur 6 near waltzer and Jackson circler on chromosome 10 ; and Glur 7 near clasper on chromosome 4 . . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization was used to document the distribution of mRNA encoding six subunit isoforms of non N methyl D aspartic acid ( NMDA ) glutamate receptors ( GluR 1 , GluR 2 , GluR 3 , GluR 4 , GluR 5 and GluR 6 ) in the inner ears of embryonic , postnatal and adult rats . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The G protein coupled metabotropic glutamate receptor mGluR 1 alpha and the ionotropic glutamate receptor GluR 6 were examined for posttranslational palmitoylation . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We describe the isolation of a molluscan ( Lymnaea stagnalis ) full length complementary DNA that encodes a mature polypeptide ( which we have named Lym eGluR 2 ) with a predicted molecular weight of 105 kDa that exhibits 44 48 % identity to the mammalian kainate selective glutamate receptor GluR 5 , GluR 6 , and GluR 7 subunits . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Patch clamp methods have been used to examine single channel properties of recombinant GluR 5 and GluR 6 kainate preferring glutamate receptors which differ in a single amino acid residue as a result of RNA editing at the Q / R ( glutamine / arginine ) site . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In contrast to GABAA receptors , glutamate receptors expressed from mouse cortical mRNA or from cRNAs encoding AMPA ( GluR 3 ) or kainate ( GluR 6 ) selective subunits were much less sensitive to longer chain alcohols . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The isolated GFP streptavidin fusion protein , which possessed fluorescence properties identical to those of the native GFP , was capable of binding biotin as shown by using biotinylated beads as well as biotinylated antibody complexes decorating surface expressed GluR 6 glutamate receptor in live and fixed insect cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Structural models have been produced for three types of non NMDA inotropic glutamate receptors : an AMPA receptor , GluR 1 , a kainate receptor , GluR 6 ; and a low molecular weight kainate receptor from goldfish , GFKAR alpha . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In addition to the clinical anesthetics enflurane , isoflurane and halothane , we tested novel halogenated compounds , which are anesthetic or nonanesthetic in vivo , on glutamate receptor ( GluR ) subunits . these volatile compounds as well as pentobarbital and phenobarbital were tested on kainate induced currents in Xenopus oocytes expressing GluR 1 , GluR 3 , GluR2+3 or GluR 6 subunits . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Concentration response data were obtained for KA and glutamate activation of homomeric GluR 6 ( R ) channels and fitted with Hill type equations to give values for the agonist concentration at half maximal activation ( EC 50 ) , the Hill coefficient ( nH ) , and the maximum current ( Imax ) . ^^^ The Imax values obtained for KA and glutamate in the same cells were similar , suggesting that both KA and glutamate are full agonists at homomeric GluR 6 ( R ) channels . 3 . ^^^ Spectral density analysis of current noise evoked by KA and glutamate in GluR 6 ( R ) expressing cells , or in outside out patches from these cells , was used to obtain estimates of the apparent unitary conductance ( gamma noise ) of homomeric GluR 6 ( R ) channels . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kinetics of homomeric GluR 6 glutamate receptor channels . ^^^ We studied the kinetics of the unedited version of rat GluR 6 glutamate ( glu ) receptor channels , GluR6Q , in outside out patches using a system for submillisecond solution exchange . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Lack of evidence for close linkage of the glutamate GluR 6 receptor gene with schizophrenia . ^^^ To test this hypothesis the authors sought to detect linkage between the GluR 6 glutamate receptor gene and schizophrenia . ^^^ METHOD : Twenty three English and Icelandic families containing multiple cases of schizophrenia were genotyped with a microsatellite trinucleotide repeat polymorphism localized at the GluR 6 glutamate receptor locus . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RNA editing of glutamate receptor subunits GluR 2 , GluR 5 and GluR 6 in transient cerebral ischemia in the rat . ^^^ Total RNA was extracted from the cortex , striatum , and hippocampus in order to analyze the extent of mRNA editing of the glutamate receptor subunits GluR 2 , GluR 5 , and GluR 6 . ^^^ Results indicate that mRNA editing is regulated differently in each of the glutamate receptor subunits GluR 2 , GluR 5 , and GluR 6 after transient cerebral ischemia . ^^^ Studying ischemia induced changes in mRNA editing of glutamate receptor subunits GluR 5 and GluR 6 may help to elucidate the molecular mechanisms of ischemic cell damage . . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In contrast , we demonstrate herein that EB potently inhibits glutamate evoked currents mediated by the kainate type receptor GluR 6 ( IC 50 150 nM ) as well as the AMPA type receptor GluR 1 ( IC 50 = 220 nM ) in whole cell patch clamp recordings from transfected human embryonic kidney 293 cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Developmental changes of RNA editing of glutamate receptor subunits GluR 5 and GluR 6 : in vivo versus in vitro . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Distribution of desensitization time constants of mouse embryonic like nicotinic and homomeric GLUR 6 glutamate receptor channels . ^^^ In response to application of saturating concentrations of acetylcholine ( ACh ) or glutamate ( Glu ) . the peak current was reached in a submillisecond range and decayed monexponentially in the presence of the agonist , due to desensitization . tauD varied from 10 ms to 100 ms with a mean value of 55 . 0 + / 22 . 6 ms ( n = 133 ) in response to pulses of 10 ( 4 ) M ACh for embryonic like nAChR channels and from 2 . 6 ms to 8 . 9 ms with a mean value of 5 . 0 + / 1 . 9 ms ( n = 35 ) in response to pulses of 10 ( 2 ) M Glu for homomeric GluR 6 receptor channels . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PEPA ( 1 200 microM ) dose dependently potentiated glutamate evoked currents in Xenopus oocytes expressing AMPA ( GluRA GluRD ) , but not kainate ( GluR 6 and GluR6+KA2 ) or NMDA ( zeta 1 + epsilon 1 epsilon4 ) , receptor subunits . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The potencies of kainate , glutamate and diastereomers of 4 methylglutamate were determined for activation and steady state desensitization of GluR 6 and dorsal root ganglion type kainate receptors using whole cell voltage clamp . ^^^ The EC 50 for receptor activation by 2S , 4R 4MG ( 1 . 0 microM ) was similar to that for kainic acid ( 1 . 8 microM ) , but 2S , 4R 4MG was significantly more potent than kainate , glutamate or the other diastereomers of 4 methylglutamate at producing steady state desensitization of GluR 6 receptors . ^^^ For GluR 6 , recovery from desensitization displayed a similar time course for kainate and glutamate ( tau = 3 4 s ) but was roughly 20 fold slower for 2S , 4R 4MG , which suggests that the rate of recovery is not entirely dependent on the affinity of ligand for the desensitized receptor . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Permeation and block of rat GluR 6 glutamate receptor channels by internal and external polyamines . 1 . ^^^ Polyamine block of rat GluR 6 ( Q ) glutamate receptor channels was studied in outside out patches from transiently transfected HEK 293 cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To investigate possible reasons for the apparent lack of ion channel function we transplanted the ion channel domains of five KBPs into glutamate receptors GluR 6 and GluR 1 . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Control of rat GluR 6 glutamate receptor open probability by protein kinase A and calcineurin . 1 . ^^^ We have used non stationary variance analysis to examine the single channel conductance and the probability of channel opening at the peak of the homomeric GluR 6 response ( Po , peak ) to 100 200 ms application ( 10 90 % exchange time , 0 . 3 ms ) of glutamate onto excised membrane patches from transiently transfected human embryonic kidney cells ( HEK 293 ) . 2 . ^^^ We conclude that the binding of glutamate to homomeric GluR 6 receptors is associated with a high probability of channel opening , which is under the control of two signalling systems that are known to be co localized at the neuronal membrane : PKA ( Po , peak near 1 . 0 ) and calcineurin ( Po , peak near 0 . 5 ) . . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Characterization of RNA editing of the glutamate receptor subunits GluR 5 and GluR 6 in granule cells during cerebellar development . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Characterization of the kainate binding domain of the glutamate receptor GluR 6 subunit . ^^^ Recombinant fragments of the kainate selective glutamate recepto subunit GluR 6 were expressed in insect cells and analysed for [ 3H ] kainate binding activity in order to characterize the structural determinants responsible for ligand recognition . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The major excitatory neurotransmitter in the central nervous system is glutamate , and recent studies found that volatile anesthetics inhibit the function of the alpha amino 3 hydroxyisoxazolepropionic acid subtype of glutamate receptors ( e . g . glutamate receptor 3 ( GluR 3 ) ) , but enhance kainate ( GluR 6 ) receptor function . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Primary rat cortical neurons were found to express GluR 1 to GluR 3 and NR 1 , NR2A , and NR2B by both immunocytochemistry and RT PCR and KA 1 , KA 2 , GluR 5 , GluR 6 , and GluR 7 by RT PCR . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| IW potently elicited currents from glutamate receptor 5 ( GluR 5 ) expressing cells , but showed no activity on homomeric GluR 6 or GluR 7 receptors . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An analysis of philanthotoxin block for recombinant rat GluR 6 ( Q ) glutamate receptor channels . 1 . ^^^ The action of philanthotoxin 343 ( PhTX ) on rat homomeric GluR 6 ( Q ) recombinant glutamate receptor channels was analysed using concentration jump techniques and outside out patches from HEK 293 cells . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Editing status at the Q / R site of the GluR 2 and GluR 6 glutamate receptor subunits in the surgically excised hippocampus of patients with refractory epilepsy . ^^^ The editing status of mRNA at the Q / R site of the glutamate receptor subunits GluR 2 and GluR 6 modulates channel conductivity and ion selectivity of ionotropic AMPA / KA receptors . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Whole cell recordings from cultured rat hippocampal neurons , from freshly dissociated dorsal root ganglion ( DRG ) neurons and from human embryonic kidney ( HEK ) 293 cells expressing the glutamate receptor GluR 6 subunit were used to study the modulation of kainate receptor channels by long chain fatty acids . 2 . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We found that replacing the glutamate binding domain S 1 of GluR 3 ( an AMPA receptor ) with S 1 of GluR 6 ( a kainate receptor ) resulted in a fully active but completely nondesensitizing receptor . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In situ hybridization and immunohistochemistry were used to determine the presence of kainate preferring glutamate receptor subunits GluR 6 and GluR 7 mRNA and protein in the median eminence of the rat . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The activation inactivation properties of membrane currents induced by the rapid application of glutamate or kainate were studied in cultured hippocampal neurons and in HEK cells transfected with a cDNA encoding the GluR 6 subunit . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Within the kainate class of glutamate receptors , LY 339434 showed selectivity for GluR 5 over GluR 6 whereas ( 2S , 4R ) 4 methylglutamic acid showed high affinity for both GluR 5 and GluR 6 kainate receptors . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Block of kainate subtype glutamate receptor channels by internal polyamines was analysed using outside out patches from HEK 293 cells transiently transfected with GluR 6 ( Q ) . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The main glutamate receptor subunits detected in IS cells were GluR 1 flop and GluR 2 flop , GluR 5 and GluR 6 , and NR2B and NR2D for the alpha amino 3 hydroxyl 5 methyl 4 isoxazolepropionic acid ( AMPA ) , kainate and N methyl D aspartic acid ( NMDA ) subtypes , respectively . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Agonist induced changes in substituted cysteine accessibility reveal dynamic extracellular structure of M 3 M4 loop of glutamate receptor GluR 6 . ^^^ To test this hypothesis , we mutated Ser 684 , a putative cAMP dependent protein kinase site in the kainate type glutamate receptor GluR 6 , to Cys . ^^^ However , we find it unlikely that Cys 684 undergoes membrane translocation , because the addition of SA to Cys biotinylated GluR 6 ( S684C ) has no effect on peak glutamate evoked current and only a small effect on macroscopic desensitization . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The ionotropic glutamate receptor GluR 6 exhibits strongly and rapidly desensitizing current responses . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| However , in vitro , high levels of glutamate and potassium induced depolarizations have no effect on GluR 5 and GluR 6 Q / R editing . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| By exchanging ion pore domains between functional glutamate receptors ( GluR 1 , GluR 6 and NMDAR 1 ) with known pore properties we first tested the feasibility of the domain swapping method . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An increase in the intracellular concentration of cAMP and protein kinase A potentiates kainate activated currents in alpha motoneurons of the spinal cord by increasing the affinity of the ligand ( glutamate ) for the phosphorylated receptor protein ( GluR 6 and 7 ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RNA editing of the codon that encodes the glutamine / arginine ( Q / R ) site in the second membrane domain ( MD 2 ) of glutamate receptor 5 ( GluR 5 ) and GluR 6 kainate receptor subunits produces receptors with reduced calcium permeabilities and single channel conductances . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The effect on polyamine block of mutations at the Q / R site and the conserved negative charge +4 site in AMPA and kainate receptors was studied using the rat glutamate receptor GluR 6 expressed in Xenopus oocytes and human embryonic kidney ( HEK ) cells . 2 . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our results indicate that although GluR 6 is primarily expressed by pyramidal cells and dentate granule neurons and GluR 5 is prominently expressed in nonpyramidal cells , there is a significant population of GABAergic interneurons that coexpress the two glutamate receptor subunits . ^^^ Responses evoked by rapid application of either glutamate , ( RS ) alpha amino 3 hydroxy 5 tert butyl 4 isoxazolepropionic acid ( ATPA ) the selective agonist of GluR 5 receptors ) , and AMPA in cells cotransfected with GluR 6 ( R ) and GluR 5 ( Q ) presented a similar degree of outward rectification . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , we use gene targeted mice lacking glutamate receptor 5 ( GluR 5 ) or GluR 6 kainate receptor subunits to identify the receptor subunits that comprise the kainate receptors responsible for presynaptic modulation of CA 3 transmission . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kainate receptor glutamate receptor 6 ( GluR 6 ) subunit deficient and c Jun N terminal kinase 3 ( JNK 3 ) null mice share similar phenotypes including resistance to kainite induced epileptic seizures and neuronal toxicity ( Yang , D . ^^^ |
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| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In GluR 6 , glutamate and kainate evoked maximal currents are of the same magnitude when desensitization is inhibited with the lectin concanavalin A . ^^^ Our data show that EC ( 50 ) values for glutamate ( but not for kainate ) in GluR 7 mutants or chimeras tend to be increased in comparison to the EC ( 50 ) values in GluR 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Immunocytochemical localization of kainate selective glutamate receptor subunits GluR 5 , GluR 6 , and GluR 7 in the cat retina . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The ionotropic glutamate receptor subunit GluR 6 undergoes developmentally and regionally regulated Q / R site RNA editing that reduces the calcium permeability of GluR 6 containing kainate receptors . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This region contains the glutamate receptor 6 ( GluR 6 or GRIK 2 ) gene , a functional candidate for the syndrome . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We have generated transgenic mice expressing the kainate receptor subunit glutamate receptor 6 ( GluR 6 ) bearing an extracellular myc epitope ( myc GluR 6 ) , in forebrain neurons , in which it assembles with endogenous kainate receptor subunits . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , neurons isolated from KA receptor subunit deficient mice were used to evaluate the contribution of glutamate receptor subunit 5 ( GluR 5 ) and GluR 6 to the presynaptic control of transmitter release and to KA receptor mediated whole cell currents in these two cell populations [ corrected ] . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the activation of GluR 5 and GluR 6 kainate receptor subtypes by endogenous glutamate during seizures may be associated with the drug resistance phenomenon . . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| For glutamate receptor 6 ( GluR 6 ) kainate receptors , two unrelated proteins , concanavalin A ( Con A ) and postsynaptic density protein 95 ( PSD 95 ) , bind to extra and intracellular domains , respectively , but are reported to exert similar effects on GluR 6 desensitization behaviour . ^^^ The rate of desensitization elicited by 10 mM L glutamate was similar in control ( taufast = 5 . 5 + / 0 . 4 ms ) , Con A treated patches ( taufast = 6 . 1 + / 0 . 5 ms ) and patches containing PSD 95 and GluR 6 receptors ( taufast = 4 . 7 + / 0 . 6 ms ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The ionotropic glutamate receptor ( GluR ) subunits GluR 2 , GluR 5 and GluR 6 are subject to RNA editing at their Q / R sites , resulting in significant alterations in the channel properties of the receptors . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The chimeras were constructed between the C . elegans glutamate receptor pore domains and either the rat kainate receptor subunit GluR 6 , the alpha amino 3 hydroxy 5 methyl 4 isoxazole propionate ( AMPA ) receptor subunit GluR 1 , or the N methyl d aspartate ( NMDA ) receptor subunit NMDAR 1 1a . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| However , we show here that in contrast to AMPA receptor mediated responses ( native or recombinant GluR 3 receptor ) , the response of native and recombinant ( GluR 6 ) kainate receptors to glutamate was drastically reduced in the absence of extracellular Na+ ( i . e . , when replaced by Cs+ ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate receptor RNA editing : a molecular analysis of GluR 2 , GluR 5 and GluR 6 in human brain tissues and in NT 2 cells following in vitro neural differentiation . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| GluR 6 is an ionotropic glutamate receptor subunit of the kainate subtype . ^^^ Prior to laser photolysis , the caged glutamate did not activate the GluR 6 channel , nor did it inhibit or potentiate the glutamate response . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In addition , reverse transcription polymerase chain reaction technique and sequencing analysis revealed that glutamate transporters ( GLT 1 and EAAC 1 ) and ionotropic glutamate receptors ( NR 1 , NR2B , GluR 6 , and KA 2 ) existed in mouse sperm as well as in human sperm . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this report , we define a critical forward trafficking motif that is necessary for surface expression of the glutamate receptor 6 ( GluR 6 ) kainate receptor as well as chimeric proteins containing only the GluR 6 C terminal domain . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In addition , RT PCR results revealed that glutamate transporters ( GLT 1 and EAAC 1 ) and ionotropic glutamate receptors ( NR 1 , NR2B , GluR 6 and KA 2 ) were expressed in mouse testis . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kynurenic acid was also found to differentiate between GluR 6 and GluR6 / KA2 receptors , antagonizing glutamate at GluR 6 ( IC 50 = 0 . 4 mM ) , while having no effect at GluR6 / KA2 channels . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Among the genes located in this region is the glutamate receptor ionotropic kainate 2 gene ( GRIK 2 or GLUR 6 ) , a functional candidate for susceptibility to schizophrenia . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Recently , Jamain et al . reported that the glutamate receptor 6 ( GluR 6 or GRIK 2 ) is in linkage disequilibrium with autism . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Using KAR knock out mice , we show that subunits glutamate receptor ( GluR ) 5 and GluR 6 play distinct roles in kainate induced gamma oscillations and epileptiform burst activity . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| For example , expression of GLT 1 and GluR 6 mRNAs was enhanced , whereas diminished expression of the neuronal glutamate transporter EAAC 1 , GABAAalpha 2 , GABAAgamma 2 , GABAAgamma 3 , NMDA2B , GluR 1 , GluR 2 , GluR 4 , and GluR 5 subunits occurred . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Altered behavioral responses to noxious stimuli and fear in glutamate receptor 5 ( GluR 5 ) or GluR 6 deficient mice . ^^^ Here we show that responses to capsaicin or inflammatory pain were significantly reduced in mice lacking glutamate receptor 5 ( GluR 5 ) but not GluR 6 subunits . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To identify NTD subdomains involved in this process we generated AMPA glutamate receptor 3 ( GluR 3 ) mutants having intra NTD substitutions with the corresponding regions of the kainate receptor GluR 6 and tested their ability to form functional heteromers with wild type subunits . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , most glutamate induced cobalt stained cells showed GluR 6 and KA 1 like immunoreactivity . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Crystal structures of the GluR 5 and GluR 6 kainate receptor ligand binding cores in complexes with glutamate , 2S , 4R 4 methylglutamate , kainate , and quisqualate have now been solved . ^^^ Strikingly , the extent of domain closure produced by the GluR 6 partial agonist kainate is only 3 degrees less than for glutamate and 11 degrees greater than for the GluR 2 kainate complex . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Time dependent effect of kainate induced seizures on glutamate receptor GluR 5 , GluR 6 , and GluR 7 mRNA and Protein Expression in rat hippocampus . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The affinity of 2 for GluR 6 glutamate receptors was 240 fold lower than for 1 , indicating low neurotoxic potential . . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kainate preferring glutamate receptor subunits ( GluR 5 , GluR 6 , GluR 7 , KA 1 , and KA 2 ) form one of the three ionotropic receptor families . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In radioligand binding assays , neoDH displayed a 15 to 25 fold lower affinity relative to that of DH for glutamate receptor ( GluR ) 5 and GluR 6 kainate receptor subunits but a 7 fold higher affinity for kainate ( KA ) 2 subunits , whereas MSVIII 19 displaced [ ( 3 ) H ] kainate only from GluR 5 subunits but not GluR 6 or KA 2 subunits . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The present study examined whether the hypothalamic expression of three key ionotropic glutamate receptor subunits ( NMDAR 1 , GluR 1 and GluR 6 ) fluctuates significantly on proestrus in the rat , and whether treatment with the antiprogestin , RU 486 affected glutamate receptor subunit expression . ^^^ As a whole , the studies suggest that glutamate receptor expression fluctuates little on proestrus in the hypothalamus , but that expression of the kainate GluR 6 receptor subunit may be modulated by progesterone and aging . . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Genomic sequences for the glutamate receptor 2 ( GluR 2 ) subunit of AMPA receptors and the GluR 5 and GluR 6 subunits of kainate receptors all encode a neutral glutamine ( Q ) residue within the channel pore that can be converted by RNA editing to a positively charged arginine ( R ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kainate receptor glutamate receptor 6 ( GluR 6 ) binds to the postsynaptic density protein 95 ( PSD 95 ) , which in turn anchors mixed lineage kinase 3 ( MLK 3 ) via SH 3 domain in rat brain tissue . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In contrast , mutant mice showed altered response in mRNA levels of N methyl D aspartate , GLUR 5 and GLUR 6 glutamate receptor subunits as well as of enkephalin following cocaine administration . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Heteromeric kainate receptors ( KARs ) containing both glutamate receptor 6 ( GluR 6 ) and KA 2 subunits are involved in KAR mediated EPSCs at mossy fiber synapses in CA 3 pyramidal cells . ^^^ In GluR 6 ( / ) mice , both ionotropic synaptic transmission and inhibition of 1 ( sAHP ) by endogenous glutamate released from mossy fibers was lost . ^^^ We propose a model in which KARs could operate in two modes at mossy fiber synapses : through a direct ionotropic action of GluR 6 , and through an indirect G protein coupled mechanism requiring the binding of glutamate to KA2 . . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| When GluR 6 KA receptors ( KARs ) were pre incubated with Con A , equilibrium responses evoked by the full agonist , l glutamate ( l Glu ) , increased almost 30 fold . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The crystal structures reveal the structural basis for the high selectivity for GluR 5 observed in radiolabel displacement assays for the isolated ligand binding cores of the GluR 2 , GluR 5 , and GluR 6 subunits and during inhibition of glutamate activated currents in studies on full length ion channels . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Previous studies have suggested that glutamate receptor 6 ( GluR 6 ) subunit and JNK deficient mice can resist kainate induced epileptic seizure and neuronal toxicity ( Yang , D . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , CaM kinase 2 enhanced kainate currents of expressed glutamate receptor 6 in 293 cells and of wild type glutamate receptor 1 , but not the Ser 627 to Ala mutant , in Xenopus oocytes . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PCREB IR and c fos gene expression in the PKC alpha positive rod bipolar cells were lost in mice lacking metabotropic glutamate receptor 6 ( mGluR 6 ) . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The AMPA receptor antagonist GYKI 52466 failed to block ionotropic glutamate receptor mediated facilitation , but the ionotropic glutamate receptor 6 kainate receptor subunit antagonist NS 102 was a potent blocker . ^^^ Taken together , our results indicate that , in the cerebral cortex , both kainate and AMPA may be facilitating glutamate release through the activation of a high affinity kainate receptor containing glutamate receptor 6 kainate subunits . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Antibodies raised against group 1 ( metabotropic glutamate receptor 1alpha , metabotropic glutamate receptor 5 ) , group 2 ( metabotropic glutamate receptor 2 / 3 ) and group 3 ( metabotropic glutamate receptor 6 ) metabotropic glutamate receptor subtypes were used to label acutely dissociated horizontal , bipolar and Mller cells . ^^^ Results from immunostaining provide evidence that cone horizontal cells express group 1 ( metabotropic glutamate receptor 1alpha , metabotropic glutamate receptor 5 ) and group 3 ( metabotropic glutamate receptor 6 ) , but not group 2 ( metabotropic glutamate receptor 2 / 3 ) receptor subtypes , consistent with our electrophysiological results . ^^^ There was no evidence for a group of bipolar cells that did not stain with the antimetabotropic glutamate receptor antibodies , although the densest immunostaining occurred when bipolar cells were incubated with the anti metabotropic glutamate receptor 6 antibody . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| ON bipolar neurons in retina detect the glutamate released by rods and cones via metabotropic glutamate receptor 6 ( mGluR 6 ) , whose cascade is unknown . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| An intriguing finding was the presence of GluR2 / 3 and GluR 4 subunits on dendrites of putative rod bipolar cells , which are thought to signal through the sign inverting metabotropic glutamate receptor 6 , mGluR 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Identification of novel alternatively spliced mRNA isoforms of metabotropic glutamate receptor 6 gene in rat and human retina . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Amino acid residues involved in glutamate receptor 6 kainate receptor gating and desensitization . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A retinal specific regulator of G protein signaling interacts with Galpha ( o ) and accelerates an expressed metabotropic glutamate receptor 6 cascade . ^^^ In retina , Galpha ( o 1 ) is obligatory in mediating the metabotropic glutamate receptor 6 ( mGluR 6 ) initiated ON response . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our previous studies have demonstrated that the JNK signaling pathway plays an important role in ischemic brain injury and is mediated via glutamate receptor 6 . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In conclusion , our data demonstrate that the metabotropic glutamate receptor 6 mRNA levels are altered in the young and adult RCS rat retina and suggest that the genetically induced degeneration of photoreceptors affects the expression of this receptor by the INL retinal neurons . . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Mice lacking the metabotropic glutamate receptor 6 ( Grm 6 ) have a defect in signal transmission from the photoreceptors to ON bipolar cells . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To elucidate the mechanism of translocation and activation , we administered N acetylcysteine , an antioxidant reagent , and a glutamate receptor 6 C terminus containing peptide ( Tat GluR 6 9c ) to rats . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Frequency and transmission of glutamate receptors GRIK 2 and GRIK 3 polymorphisms in patients with obsessive compulsive disorder . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Using a native chromatin immunoprecipitation assay , we studied histone methylation marks at proximal promoters of 16 ionotropic and metabotropic glutamate receptor genes ( GRIN 1 , 2A D ; GRIA 1 , 3 , 4 ; GRIK 2 , 4 , 5 ; GRM 1 , 3 , 4 , 6 , 7 ) in cerebellar cortex collected across a wide age range from midgestation to 90 years old . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Interestingly , only genes for the kainate 2 subunit of ionotropic glutamate receptor ( Grik 2 , also known as KA 2 ) and the 5 hydroxytryptamine ( serotonin ) receptor 7 ( Htr 7 ) ( but not GABA ( A ) subunits and adrenergic receptor alpha1b ) were still upregulated in adulthood . cAMP responsive element binding protein and Homer 1a transcripts were modulated only as a long term effect . ^^^ |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13002 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|