| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Internalization assays reveal that like PSD 95 , both SAP 97 and PSD 93 inhibit NR2B mediated endocytosis . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We now show that SAP 97 , a SAP whose function at the synapse has been unclear , is associated with alpha amino 3 hydroxy 5 methylisoxazole 4 propionic acid ( AMPA ) type glutamate receptors . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The NR2B subunit interacts with post synaptic density protein 95 ( PSD 95 ) , SAP 97 and members of the membrane associated guanylate like kinase ( MAGUK ) family of proteins . ^^^ This interaction occurs through the binding of the C terminal tSXV intracellular motif of the NR2B subunit to the N terminal PDZ ( PSD 95 , discs large , ZO 1 ) domains of the PSD 95 and SAP 97 proteins . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this report , we demonstrate that glutamate receptors and PKA are recruited into a macromolecular signaling complex through direct interaction between the MAGUK proteins , PSD 95 and SAP 97 , and AKAP79 / 150 . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In vivo , SAP 90 tightly binds kainate receptor subunits , while SAP 97 is only weakly associated , suggesting that this glutamate receptor differentially associates with SAP90 / PSD 95 family members . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synaptic glutamate receptor clustering in mice lacking the SH 3 and GK domains of SAP 97 . ^^^ As SAP 97 has been implicated in the early intracellular processing of the glutamate receptor GluR 1 , we studied biochemical maturation and subcellular localization of GluR 1 in the mutants . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this regard , SAP 97 has been suggested to regulate the synaptic localization of glutamate receptor type 1 subunits of the AMPA type glutamate receptors . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synapse associated protein 97 ( SAP 97 ) , a member of membrane associated guanylate kinase protein family , has been implicated in the processes of targeting ionotropic glutamate receptors at postsynaptic sites . ^^^ Here we show that SAP 97 is enriched at the postsynaptic density where it co localizes with both ionotropic glutamate receptors and downstream signaling proteins such as Ca2+ / calmodulin dependent protein kinase 2 ( CaMKII ) . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synapse associated protein 97 ( SAP 97 ) has been involved in the correct delivery and clustering of glutamate ionotropic receptors to the postsynaptic compartment . ^^^ Further , CaMKII dependent SAP 97 Ser 39 phosphorylation determined a redistribution of the glutamate receptor subunit ( GluR 1 ) of the AMPA receptor . ^^^ In conclusion , our data show that CaMKII dependent SAP 97 Ser 39 phosphorylation regulates the association of SAP 97 with the postsynaptic complex , thus providing a fine molecular mechanism responsible for the synaptic delivery of SAP 97 interacting proteins , i . e . ionotropic glutamate receptor subunits . . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Importantly , we find that sv / sv hippocampal neurons display a significant deficit in the stimulation induced internalization of alpha amino 3 hydroxy 5 methyl 4 isoxazole propionic acid type glutamate receptors ( AMPARs ) , and that Myo 6 exists in a complex with the AMPAR , AP 2 , and SAP 97 in brain . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To determine whether gene expression of AMPARs and / or AMPAR binding proteins , which control response / sensitivity of AMPAR bearing neurons to glutamate , are altered in schizophrenia , mRNA expression and abundance of AMPAR subunits ( GluR 1 4 ) and several AMPAR binding proteins ( SAP 97 , PICK 1 , GRIP , ABP ) were measured in the dorsolateral prefrontal cortex ( DLPFC ) and the occipital cortex of elderly schizophrenia patients ( n = 36 ) and matched normal controls ( n = 26 ) by quantitative real time PCR . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Chronic treatment with CX 614 gradually reduced levels of glutamate receptor ( GluR ) 1 and GluR2 / 3 AMPAr subunits and of their anchoring proteins synapse associated protein 97 ( SAP 97 ) and glutamate receptor interacting protein 1 ( GRIP 1 ) through 48 h . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The synapse associated protein 97 ( SAP 97 ) is important in the proper trafficking and cell surface maintenance of the N methyl D aspartate ionotropic glutamate receptor . ^^^ The molecular scaffold / receptor interaction is mediated by the association of the C terminus of the NR2B subunit of the N methyl D aspartate receptor with the PDZ domains of SAP 97 . ^^^ Here , we characterize the binding of the C terminus of NR2B with the PDZ domains of SAP 97 and determine the structure of the PDZ 1 NR2B complex employing high resolution NMR . ^^^ Based on fluorescence anisotropy , the NR2B subunit binds to the first and second PDZ domains of SAP 97 , with higher affinity for PDZ 2 ; no appreciable binding to PDZ 3 could be measured . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In short term neocortical cultures , concentrations of epidermal growth factor and amphiregulin ( 2 9 pM ) decreased the expression of glutamate receptor interacting protein 1 ( GRIP 1 ) and synapse associated protein 97 kDa ( SAP 97 ) without affecting postsynaptic density 95 ( PSD 95 ) levels and glial proliferation . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synapse associated protein 97 ( SAP 97 ) and postsynaptic density 95 ( PSD 95 ) are closely related membrane associated guanylate kinase homologs ( Maguks ) implicated in the synaptic targeting and anchoring of alpha amino 5 methyl 3 hydroxy 4 isoxazolepropionic acid ( AMPA ) selective glutamate receptors . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Expression of SAP 97 recruited a complex of additional postsynaptic proteins to synapses including glutamate receptor 1 , Shank1a , SPAR ( spine associated RapGAP ) , and proSAP 2 . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In cerebral heterotopia , the NR2A and NR2B downregulation was accompanied by less evident reduction of the SAP 97 and PSD 95 proteins of the MAGUK family , thus suggesting that NMDA impairment was associated with altered molecular structure of the postsynaptic membrane . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In contrast , other AMPA receptor interacting proteins , such as synapse associated protein 97 , glutamate receptor interacting protein 1 , protein kinase Calpha binding protein , N ethylmaleimide sensitive fusion protein , AP 2 , and protein 4 . 1N , do not show significant association with AMPA receptor complexes on native gels . ^^^ |
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| Interacting proteins: Q12959 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These events are paralleled by profound modifications of NMDA receptor NR2B subunit association with interacting elements , i . e . , members of the membrane associated guanylate kinase ( MAGUK ) protein family postsynaptic density 95 , synapse associated protein 97 and synapse associated protein 102 . ^^^ |
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