| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These vesicles were characterised by [ 3H ] glutamate and [ 3H ] dopamine uptake and by immunoblot analysis , using glial and synaptic markers : glutamate synthase , SNAP 25 and synaptobrevin . [ 3H ] 5 HT was taken up into glial plasmalemmal vesicles in a high affinity ( Km approximately 40 nM ) , Na+ dependent , paroxetine sensitive manner . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These results provide new insights into the role of SNAP 25 in membrane remodelling in relation to specific cell types and functions , and into intraretinal regulatory mechanisms that seem to be independent of the levels of glutamate and the influence of retinal ganglion cells . . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This presynaptic modulation requires SNARE proteins because cleavage of SNAP 25 with the botulinum neurotoxin A strongly reduced the desipramine induced glutamate release . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Seven days after exposure , GAP 43 decreased to 15 % and SNAP 25 to 30 % in the glutamate injured , untreated neurons . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| With botulinum toxin type E , < 10 % of intact SNAP 25 remained and K ( + ) evoked release of glutamate and GABA was inhibited . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| SNAP 25 functional domains in SNARE core complex assembly and glutamate release of cerebellar granule cells . ^^^ In this report , we have generated SNAP 25 mutants and assayed their functions in SNARE complex formation and glutamate release from cultured rat cerebellar granule cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Immunofluorescent localizations reveal peripheral SNAP 25 expression on osteoblastic cells , particularly at intercellular contact sites , colocalizing with immunoreactive glutamate and the synaptic vesicle specific protein , synapsin 1 . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Botulinum neurotoxin A specifically removes 9 amino acids from the C terminus of SNAP 25 and efficiently blocks KCl evoked glutamate release from synaptosomes . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Blockade of glutamate release was linked to selective proteolysis of one of the following synaptic proteins : synaptobrevin ( BoNT / D , BoNT / F ) ; SNAP 25 ( BoNT / A , BoNT / E ) , or HPC 1 / syntaxin ( BoNT / C1 ) . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Using a cell free , lysed synaptosomal membrane preparation , we show that Ca2+ alone is sufficient to trigger secretion of glutamate and furthermore that Ca ( 2+ ) signaled exocytosis is effectively blocked by antibodies and peptides to SNAP 25 , a key constituent of the vesicle docking complex . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| While we were not able to demonstrate the presence of SNAP 25 or syntaxin immunoreactivity in cultured astrocytes , pretreatment with BoTx A ( which cleaves SNAP 25 ) and BoTx C ( which cleaves syntaxins ) result in a decrease in the baseline release of glutamate and diminish the bradykinin evoked release of glutamate from cultured astrocytes . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Single or double mutations of glutamine to glutamate or to arginine in the central zero layer residues of SNAP 25 did not impair the extent , time course or Ca2+ dependency of exocytosis in PC 12 cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Both truncated SNAP 25 products inhibited depolarization dependent glutamate release from hippocampal cultures and depressed synaptic transmission in Aplysia buccal ganglion cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| After proteolytic cleavage of native SNAP 25 by botulinum neurotoxin E ( BoNT / E ) , synaptic transmission was restored in a subset of transfected CA 3 pyramidal cells with a toxin resistant form of SNAP 25 containing unaltered S 187 ( Swt ) , S 187 mutated to alanine ( SA ) or S 187 mutated to glutamate ( SE ) . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Overexpression of dysbindin induced the expression of two pre synaptic proteins , SNAP 25 and synapsin 1 , and increased extracellular basal glutamate levels and release of glutamate evoked by high potassium . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Calpain inhibitors abolished the Ca2+ dependent cleavage of SNAP 25 and markedly facilitated Ca2+ dependent glutamate ( Glu ) release from cerebellar granule cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , we show that in transgenic mice overexpressing the human AD gene APPswe ( Tg 2576 ) , safflower oil induced n 3 PFA deficiency caused a decrease in N methyl D aspartate ( NMDA ) receptor subunits , NR2A and NR2B , in the cortex and hippocampus with no loss of the presynaptic markers , synaptophysin and synaptosomal associated protein 25 ( SNAP 25 ) . n 3 PFA depletion also decreased the NR 1 subunit in the hippocampus and Ca2+ / calmodulin dependent protein kinase ( CaMKII ) in the cortex of Tg 2576 mice . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Synaptosome associated protein of 25 kDa ( SNAP 25 ) is a plasma membrane Q ( containing glutamate ) SNARE essential for Ca2+ dependent secretory vesicle plasma membrane fusion in neuroendocrine cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here we studied whether GLT 1 down regulation induced by chronic clozapine treatment is associated with changes in the expression of synaptophysin , synaptosome associated protein of 25 kDa ( SNAP 25 ) and vesicular glutamate transporter 1 ( VGLUT 1 ) , three major presynaptic proteins involved in neurotransmitter release . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The g . c . chromatogram and mass spectrum of ammonia derived N trifluoroacetyl dibutylglutamate ( TAB glutamate ) are shown in Supplementary Publication SUP 50170 ( 4 pages ) , which has been deposited at the British Library Document Supply Centre , Boston Spa , Wetherby , West Yorkshire , U . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The hyperalgesic response to glutamate and NMDA injected i . t . was antagonized by the intraplantar ( i . pl . ) injection of either MPH or SNAP . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The NO release inducing substances S nitrosoacetylpenicillamine ( SNAP ) , S nitrosoglutathione ( SNOG ) , and sodium nitroprusside ( SNP ) increased extracellular concentrations of aspartate ( Asp ) , glutamate ( Glu ) , gamma aminobutyric acid ( GABA ) , taurine ( Tau ) , acetylcholine ( ACh ) , and serotonin ( 5 HT ) . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Diameter of pial arterioles was measured before and during application of glutamate or SNAP . ^^^ Topical application of glutamate ( 0 . 1 and 1 . 0 mmol / L ) and SNAP ( 10 mumol / L ) produced an increase in clearance of FITC dextran 10K and in diameter of pial arterioles . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The exposure of chick retina from 9 day old embryos to NO generating compounds , S nitroso N acetylpe nicillamine ( SNAP ) and sodium nitroprusside ( SNP ) produced a dose dependent increase in GABA , glutamine , and glutamate release . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In hyperammonemic rats , the formation of cGMP induced by NMDA and SNAP was reduced by ca . 60 and 41 % , respectively , indicating that chronic hyperammonemia in the animal in vivo also impairs the glutamate nitric oxide cGMP pathway . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Although the NMDA stimulated release of glutamate in cerebellar granule cells prepared from lead exposed first generation pups was not different from that of the control group , the S nitroso N acetylpenicillamine ( SNAP ) stimulated release of glutamate in cerebellar granule cells obtained from lead treated pups was less elevated than that in the control . ^^^ Furthermore , in cerebellar granule cells obtained from lead exposed second generations pups , glutamate release did not respond to both NMDA and SNAP stimulation . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We activated the pathway at different steps using glutamate , SNAP , or YC 1 . ^^^ In ammonia treated neurons formation of cGMP induced by glutamate , SNAP , and YC 1 was reduced by 50 % , 56 % , and 52 % , respectively , indicating that hyperammonemia impairs activation of guanylate cyclase . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Extracellular glutamate also blocked SNAP mediated elevation of cytosolic GSH . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Application of the metabotropic glutamate receptor agonist APB , the ionotropic glutamate blocker CNQX , 8 bromo cGMP , and the nitric oxide donor SNAP all showed differential effects on the various center mediated responses displayed by dark and light adapted AII cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The co injection of S nitroso N acetyl D , L penicillamine ( SNAP ) ( 0 . 22 micromol ) or 8 bromo cGMP ( 22 . 5 nmol ) with glutamate ( 10 nmol ) , via either i . t . or i . c . v . routes , also significantly enhanced glutamate induced hyperalgesia . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| On the other hand , SNAP did not cause significant effects on EPSCs mediated by non NMDA glutamate receptors . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The SNAP induced [ 3H ] purine release was calcium dependent , but not affected by the glutamate receptor antagonists MK 801 ( ( + ) 5 methyl 10 , 11 dihydro 5H dibenzo [ a , d ] cyclohepten 5 , 10 imine ; 100 nM ) and CNQX ( 6 cyano 7 nitroquinoxaline 2 , 3 dione ; 10 microM ) . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , application of the NO donors 3 morpholinosydnonimine ( SIN 1 ) and s nitroso n acetylpenicillamine ( SNAP ) mimicked cytokine inhibition of glutamate uptake . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We used glutamate , S nitroso N acetyl DL penicillamine ( SNAP ) , and staurosporine to induce excitatory damage , oxidative stress , and apoptosis , respectively , because these mechanisms are thought to participate in various disease processes leading to degeneration of cells . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The agents used were ( 1 ) staurosporine , which induces apoptotic death via inhibition of protein kinases ; ( 2 ) kainate , which activates non NMDA glutamate receptors ; ( 3 ) thapsigargin , which releases intracellular calcium stores ; and ( 4 ) SNAP , which releases active NO species and causes necrotic cell death . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Exocytosis of glutamate receptors to the dendritic surface occurs via a SNARE [ soluble n ethylmaleimide sensitive factor attachment protein ( SNAP ) receptor ] dependent SNAP 23 mediated mechanism . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This effect was not overcome by the subsequent addition of SNAP despite a two fold increase in glutamate release . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Perfusion of an inhibitor of synaptotagmin soluble n ethylmaleimide sensitive factor attachment protein ( SNAP ) receptor SNARE mediated exocytosis depressed basal EPSC amplitudes , whereas a peptide that inhibits GluR2 / 3 interactions with postsynaptic density 95 ( PDZ ) domain proteins glutamate receptor interacting protein ( GRIP ) / protein interacting with C kinase 1 ( PICK 1 ) enhanced basal synaptic transmission . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| When S nitroso N acetylpenicillamine ( SNAP ) , a nitric oxide ( NO ) donor , was infused into the hippocampus , an increase in glutamate , a decrease in glutamine and no change in arginine were recorded . ^^^ The effect of SNAP on extracellular glutamine levels was reversed by prior infusion of the guanylate cyclase inhibitor oxadiazolo [ 4 , 3 alpha ] quinoxalin 1 one ( ODQ ) , however its effect on glutamate release was unchanged . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| When NO donors , S nitroso N acetyl DL penicillamine ( SNAP ; 1 mM ) or ( Z ) 1 [ 2 ( 2 aminoethyl ) N ( 2 ammonioethyl ) amino ] diazen 1 ium 1 , 2 diolate ( NOC 18 ; 1 mM ) , were retrodialysed for 15 min , acetylcholine ( ACh ) , serotonin ( 5 HT ) , glutamate ( Glu ) , gamma aminobutyric acid ( GABA ) , and taurine levels were significantly increased , whereas those of dopamine ( DA ) , dihydroxyphenylacetic acid ( DOPAC ) , and 5 hydroxyindoleacetic acid ( 5 HIAA ) were decreased . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| S nitroso N acetyl D , L penicillamine ( SNAP ) , given i . pl . , greatly potentiated glutamate induced nociception and oedema formation . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To investigate where 5 HT acts in the glutamate ionotropic receptors / nitric oxide / guanosine 3 ' , 5 ' cyclic monophosphate ( cGMP ) pathway , in the present study 5 HT modulation of the cGMP response to the nitric oxide donor S nitroso penicillamine ( SNAP ) was studied in adult rat cerebellar slices . ^^^ While cGMP elevation produced by high micromolar SNAP was insensitive to 5 HT , 1 microM SNAP , expected to release nitric oxide in the low nanomolar concentration range , elicited cGMP production and endogenous glutamate release both of which could be prevented by activating presynaptic 5 HT1D receptors . ^^^ Released nitric oxide appeared responsible for cGMP production and glutamate release evoked by 1 microM SNAP , as both the effects were mimicked by the structurally unrelated nitric oxide donor 2 ( N , N diethylamino ) diazenolate 2 oxide ( 0 . 1 microM ) . ^^^ Dependency of the 1 microM SNAP evoked release of glutamate on external Ca2+ , sensitivity to presynaptic release regulating receptors and dependency on ionotropic glutamate receptor functioning , suggest that nitric oxide stimulates exocytotic like , activity dependent glutamate release . ^^^ Activation of ionotropic glutamate receptors / nitric oxide synthase / guanylyl cyclase pathway by endogenously released glutamate was involved in the cGMP response to 1 microM SNAP , as blockade of NMDA / non NMDA receptors , nitric oxide synthase or guanylyl cyclase , abolished the cGMP response . ^^^ |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P60880 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|