| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here we report that disruption of the gene encoding Jnk 3 in mice caused the mice to be resistant to the excitotoxic glutamate receptor agonist kainic acid : they showed a reduction in seizure activity and hippocampal neuron apoptosis was prevented . ^^^ These data indicate that the observed neuroprotection is due to the extinction of a Jnk 3 mediated signalling pathway , which is an important component in the pathogenesis of glutamate neurotoxicity . . ^^^ |
|
| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Kainate receptor glutamate receptor 6 ( GluR 6 ) subunit deficient and c Jun N terminal kinase 3 ( JNK 3 ) null mice share similar phenotypes including resistance to kainite induced epileptic seizures and neuronal toxicity ( Yang , D . ^^^ |
|
| Interacting proteins: P53779 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Importantly , JNK 3 is also mandatory for the intact differentiation of neurons since the functional deletion of JNK 3 caused apoptotic features such as activation of caspase 3 in untreated P 0 primary hippocampal neurons and following glutamate excitotoxicity . ^^^ |
|