| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , FGF 1 protection against glutamate toxicity was dependent on GSK3beta inactivation by the PI3K Akt but was independent of ERK . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Critical in the ability to foster cell survival during oxidative stress is the modulation of the metabotropic glutamate system , cell cycle regulation in post mitotic neurons , and control of GSK 3beta activity and presenilin integrity . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the neuroprotective effects of minocycline were blocked by phosphatidylinositol 3 kinase ( PI 3 K ) inhibitors LY 294002 and wortmannin , while pharmacologic inhibition of glycogen synthase kinase 3beta ( GSK3beta ) attenuated glutamate induced apoptosis . ^^^ In addition , immunoblots revealed that minocycline reversed the suppression of phosphorylated Akt and GSK3beta caused by glutamate , as were abolished by PI 3 K inhibitors . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The observed abnormalities included overexpression of Wnt 1 , Frizzled 1 and 2 receptors , Dishevelled 1 , downregulation of Secreted frizzled related protein 1 , GSK 3beta inactivation , microsatellite instability at the Axin locus as well as induction of beta catenin target genes , such as glutamine synthetase , glutamate transporter 1 , and Wisp 1 . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NMDA triggered GSK3beta activation was mediated by NMDAR that contained the NR2B subunit . ^^^ Conversely , overexpression of GSK3beta abolished non NR2B mediated activation of CRE driven transcription . ^^^ These data suggest that cross talk between GSK3beta and PP 1 contributes to NR2B NMDAR induced inhibition of CREB signaling by non NR2B NMDAR . ^^^ The excessive activation of NR2B PP 1 GSK3beta PP 1 circuitry may contribute to the deficits of CREB dependent neuronal plasticity in neurodegenerative diseases . . ^^^ |
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| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These data indicate that moderate stimulation of NR2B NMDAR protects against inhibition of PI3K by a Ser 9 independent inhibition of the pro apoptotic activity of GSK3beta . ^^^ Hence , the activation of NR2B and the Ser 9 independent inhibition of GSK3beta are two newly identified elements of the signaling network that mediates the pro survival effects of NMDA . . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Striata from mice that are not dopamine supersensitive did not reveal elevated D2High states ; these include mice with knockouts of adenosine A2A receptors , glycogen synthase kinase GSK3beta , metabotropic glutamate receptor 5 , dopamine D 1 or D 3 receptors , histamine H 1 , H 2 , or H 3 receptors , and rats treated with ketanserin or aD 1 antagonist . ^^^ |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P49841 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|