| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The putative PI3K inhibitor , wortmannin , decreased L [ 3H ] glutamate uptake activity by > 50 % within minutes . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Additionally , the mitogen activated protein ( MAP ) kinase inhibitor PD 98059 enhances BDNF induced glutamate receptor 1 ( GluR 1 ) protein expression , but a phosphatidylinositol 3 kinase ( PI3K ) inhibitor LY 294002 strongly reduces BDNF induced GluR 1 protein expression . ^^^ Taken together , glutamate receptors are important for the regulation of BDNF expression by neurotrophins , and MAP and PI3K kinases differentially modulate AMPA receptor expression in the cortical neurons . . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , FGF 1 protection against glutamate toxicity was dependent on GSK3beta inactivation by the PI3K Akt but was independent of ERK . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| A 1 h incubation of neuronal cultures with tetrodotoxin ( TTX ) , the PI3K inhibitor wortmannin , the NMDA receptor antagonist MK 801 or removal of extracellular calcium significantly reduced basal levels of phospho ( Ser 473 ) PKB , indicating that activity dependent glutamate release maintains PKB activation through an NMDA receptor PI3K pathway . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These results suggest that D 2 dopaminergic receptor activation plays an important role in neuroprotection against glutamate cytotoxicity and that the up regulation of Bcl 2 expression via the PI3K cascade is , at least partially , involved in this effect . . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Using two electrode voltage clamps , we investigated the effects of lidocaine on one type of glutamate transporter , EAAT 3 , and the role of protein kinase C ( PKC ) and phosphatidylinositol 3 kinase ( PI3K ) in mediating the lidocaine effects . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Pyrrolidine dithiocarbamate ( PDTC ) induction of the human glutamate cysteine ligase modulatory ( GCLM ) gene is dependent on activation of the mitogen activated protein kinases ( MAPKs ) extracellular regulated kinase ( Erk ) and p 38 , and is not affected by protein kinase C ( PKC ) or PI3K inhibitors . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In conclusion , TUDCA appears to modulate glutamate induced neuronal apoptosis , in part , by activating a PI3K dependent Bad signaling pathway . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate uptake was dose dependently decreased by inhibitors of protein kinase A ( PKA ) , [ N [ 2 ( p bromocinnamylamino ) ethyl ] 5 ( isoquinolinesulfonamide ) ] ( H 89 ) or phosphatidylinositol 3 kinase ( PI3K ) ( wortmannin ) , but not altered after protein kinase C ( PKC ) inhibition ( staurosporine ) or activation phorbol 12 myristate 13 acetate ( PMA ) . ^^^ These data suggest that trafficking of glutamate transporters can be differentially regulated by PKA , PKC and PI3K dependent signaling pathways and could therefore control total glutamate uptake activity . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our results support the presence of subtype dependent pathways regulating p 38 activation and deactivation : one involves NR1 / 2A / 2B receptors activating calcineurin and resulting in p 38 phosphorylation , and the other utilizes NR1 / 2B receptors binding to and activating PI3K and leading to the dephosphorylation of p 38 in a manner involving both NR1 / 2A / 2B receptor activation and tyrosine phosphorylation of NR2B . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These results suggest that carbamazepine at clinically relevant concentrations specifically enhances the affinity of EAAT 3 for glutamate to increase EAAT 3 activity via a PI3K dependent pathway . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Insulin modulates the activity of excitatory and inhibitory receptors including the glutamate and gamma aminobutyric acid receptors and activates two biochemical pathways : the shc ras mitogen activated protein kinase pathway and the PI3K ( phosphoinositide 3 kinase ) / PKC pathway , both of which are involved in memory processing . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These data indicate that moderate stimulation of NR2B NMDAR protects against inhibition of PI3K by a Ser 9 independent inhibition of the pro apoptotic activity of GSK3beta . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This study was undertaken to investigate the role of Akt 1 , activated by the phosphatidylinositol 3 kinase ( PI 3 K ) signaling pathway , in mediating glutamate excitotoxicity and lithium protection in cerebellar granule cells . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Recent evidence suggests that the activity and cell surface expression of a neuronal subtype of glutamate transporter , EAAC 1 , are rapidly increased by direct activation of protein kinase C and are decreased by wortmannin , an inhibitor of phosphatidylinositol 3 kinase ( PI 3 K ) . ^^^ Other growth factors , including insulin , nerve growth factor , and epidermal growth factor had no effect on glutamate transport nor did they increase PI 3 K activity . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These results suggest that PI 3 K mediates the neuroprotective effect of 17beta estradiol against glutamate induced neurotoxicity . . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We used cultured cerebellar granule cells to examine whether native group 3 metabotropic glutamate ( mGlu ) receptors are coupled to the mitogen activated protein kinase ( MAPK ) and phosphatidylinositol 3 kinase ( PI 3 K ) pathways . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We investigated the effects of ethanol on a neuronal glutamate transporter , excitatory amino acid transporter type 3 ( EAAT 3 ) , and the role of protein kinase C ( PKC ) and phosphatidylinositol 3 kinase ( PI 3 K ) in mediating these effects . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Furthermore , the neuroprotective effects of minocycline were blocked by phosphatidylinositol 3 kinase ( PI 3 K ) inhibitors LY 294002 and wortmannin , while pharmacologic inhibition of glycogen synthase kinase 3beta ( GSK3beta ) attenuated glutamate induced apoptosis . ^^^ In addition , immunoblots revealed that minocycline reversed the suppression of phosphorylated Akt and GSK3beta caused by glutamate , as were abolished by PI 3 K inhibitors . ^^^ These results demonstrate that minocycline prevents glutamate induced apoptosis in CGNs by directly inhibiting p 38 activity and maintaining the activation of PI 3 K / Akt pathway , which offers a novel modality as to how the drug exerts protective effects . . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We studied the role of the phosphatidylinositol 3 kinase ( PI 3 K ) and Ras / mitogen activated protein kinase ( MAPK ) pathways in the protection of cultured hippocampal neurons from glutamate induced apoptotic cell death , characterized by nuclear condensation and activation of caspase 3 like enzymes . ^^^ Pre incubation with the neurotrophin brain derived neurotrophic factor ( BDNF ) , for 24 h , reduced glutamate evoked apoptotic morphology and caspase 3 like activity , and transiently increased the activity of the PI 3 K and of the Ras / MAPK pathways . ^^^ Inhibition of the PI 3 K and of the Ras / MAPK signaling pathways abrogated the protective effect of BDNF against glutamate induced neuronal death and similar effects were observed upon inhibition of protein synthesis . ^^^ The results indicate that the protective effect of BDNF in hippocampal neurons against glutamate toxicity is mediated by the PI 3 K and the Ras / MAPK signaling pathways , and involves a long term change in protein synthesis . . ^^^ |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P42336 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|