| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The epidemiological data suggests a very high familial incidence of CJD in this population and a molecular genetic research elucidated that CJD segregates with a point mutation at codon 200 of the PrP gene resulting in the substitution of Lysine for Glutamate . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| CJD in this community segregates with a point mutation at codon 200 of the PrP gene which causes the substitution of lysine for glutamate . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In Libyan Jews , CJD segregates with a point mutation at codon 200 of the PrP gene , resulting in the substitution of lysine for glutamate . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In PrP null mice , the kinetics of GABA and glutamate receptor mediated currents showed no significant deviation from those in control animals . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| One female patient had familial CJD with a glutamate > lysine mutation at codon 200 of the prion protein ( PrP ) gene PRNP . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| OBJECTIVE : A new variant of Gerstmann Strussler Scheinker disease ( GSS ) was reported , which had a substitution of glutamate to lysine at codon 219 ( E219K ) in addition to a P102L mutation on the same allele of the PrP gene . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Flupirtine , which has been in clinical use since 10 years ago , prevents the toxic effect of PrP , the presumed etiologic agent of the Creutzfeldt Jakob disease as well as the excitatory amino acid glutamate on cortical neurons . ^^^ In parallel with the determination of the effect of Flupirtine on the toxin ( A beta , PrP or glutamate ) induced neuronal death the effect of the drug on the intracellular Ca2+ level [ Ca2+ ] 1 , was measured . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The data obtained testify the PRP to be a neuroprotector against many toxic compounds formed in organism ( glutamate , ceramid , beta amyloid neurotoxisity , etc . ) . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To study the mechanism underlying the selective degeneration of Purkinje cells in the cerebellum of the Nagasaki ( Ngsk ) prion protein deficient ( PrP ( / ) ) mice , the mRNA levels of glutamate transporter EAAT 4 , the marker highly specific for Purkinje cell synapses , were analyzed by semi quantitative reverse transcription polymerase chain reaction . ^^^ These results indicate that Purkinje cell degeneration found in the cerebellum of PrP ( / ) mice is not primarily caused by glutamate neurotoxicity , although it remains to be investigated whether preserved expression of EAAT 4 might represent a compensatory mechanism for protecting against Purkinje cell degeneration in the PrP ( / ) mice cerebellum . . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| PsENOD 2 is expressed in nodule parenchyma tissue during nodule organogenesis and encodes a protein with distinctive PRP motifs that are rich in glutamate and basic amino acids . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , PACAP showed neuroprotection against glutamate , human prion protein fragment 106 126 [ PrP ( 106 126 ) ] and C 2 ceramide . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Mice lacking the cellular prion protein ( PrP ( c ) ) gene ( Prnp ) present a decreased astrocytic glutamate uptake in cultures , higher neuronal excitability in vitro and sensitivity to pro convulsant drugs in vivo , and age dependent memory impairment . ^^^ Here , we investigate if PrP ( c ) might be involved in neuronal uptake and release of glutamate . ^^^ Although we observed differences in synaptosomal glutamate release and uptake regarding the age of mice and the brain structure studied , these differences were similar for PrP ( c ) null mice and their respective wild type controls . ^^^ Therefore , despite a possible correlation between neuronal glutamate transporters , excitability , and neuronal damage , our results suggest that PrP ( c ) expression is not critical for neuronal glutamate transport . . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RESULTS : 18 protein spots were differentially expressed as compared with age matched nondemented control brains which were identified as glyceraldehyde 3 phosphate dehydrogenase , uracil DNA glycosylase , human superoxide dismutase , isocitrate dehydrogenase subunit , synaptotagmin 1 , thioredoxin peroxidase 1 , glial fibrillary acidic protein , p 25 alpha , enoyl coenzyme A hydratase short chain 1 , pyridoxine 5 ' phosphate oxidase , Mn superoxide dismutase and alpha enolase , antioxidant protein 2 , ferritin heavy chain , glutamate dehydrogenase precursor , peptidyl prolyl cis trans isomerase A , serum albumin precursor and dihydropyrimidinase related protein 2 . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The covalent association of TSA , the group B polysaccharide , and the peptidoglycan was demonstrated by the presence of N acetylmuramic acid , rhamnose , alanine , glutamate , and lysine in mutanolysin extracted TSA material purified by DEAE Sephacel anion exchange and Sepharose 4B gel chromatography . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Comparison of the TSA and TSA transition state analogue structures with the crystal structure of BX 1 suggests that the faster catalytic rate of BX 1 may be due to a stabilization of the active conformation : loop alphaL 6 is closed and the catalytic glutamate is in the active conformation . ^^^ |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P32119 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|