| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| When indirect responses were blocked by adding tetrodotoxin ( 0 . 2 microM ) or manganese chloride ( 2 mM ) to the normal Ringer solution , AMBD ( 0 . 01 0 . 5 mM ) selectively antagonized taurine , beta alanine , hypotaurine and kojic amine evoked depolarizations of primary afferents at their intramedullary part ( dorsal root terminals , DRT ) and on dorsal root ganglia ( DRG ) , without significantly affecting responses to glutamate ( on DRT ) , glycine ( on DRT ) or GABA ( on DRT and DRG ) . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Stimulation of the DRt was performed by injecting glutamate ( 100 nmol / microliters ) unilaterally , which was followed 1 min later by a significant decrease in the tail flick latency compared to saline injected controls . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| DRt blocking by lidocaine results in a decrease of the nociceptive activity of spinal dorsal horn neurones , whereas stimulation by glutamate has the opposite effect . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Replacement by glutamate rendered the kinase capable of being activated by ERK activator , while replacement by alanine did not . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The chronic morphine induced increases in ERK activity and TH expression in the VTA also were blocked by local infusion of NMDA glutamate receptor antagonists , suggesting a role for glutamate in mediating these drug effects . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Conversion of L 12 of p 38 to an `` ERK like ' ' structure was accomplished in several ways : ( 1 ) by replacing glycine with glutamate in the dual phosphorylation site , ( 2 ) by placing a six amino acid sequence present in L 12 of ERK ( but absent in p 38 ) into p 38 , and ( 3 ) by mutations of amino acid residues in loop 12 . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These latter bring about on the one hand a raising of [ Ca2+ ] 1 partly due to the potentiation of the NMDA receptor response to endogenous glutamate and on the other hand the activation of certain MAP kinases ( ERK and JNK ) which lead to the initiation of the cell death program . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In cultured hippocampal neurons , simulation of glutamate receptors can activate ERK signaling , for which elevation of intracellular Ca2+ is required . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate treatment leads to a robust , progressive activation of the ERK and JNK / SAPK MAPK cascades . ^^^ ERK and Elk 1 phosphorylation are blocked by the MAPK kinase inhibitor PD 98059 , indicating the primary role of the ERK cascade in mediating glutamate signaling to Elk 1 in the rat striatum in vivo . ^^^ Interestingly , KN 62 , which interferes with calcium calmodulin kinase ( CaM K ) activity , leads to a reduction of glutamate induced ERK activation and of CREB phosphorylation . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Activation of metabotropic glutamate receptors ( mGluRs ) leads to modulation of a variety of second messenger pathways probably including the mitogen activated protein kinase ( MAPK ) extracellular signal regulated protein kinases ( ERK ) . ^^^ However , glutamate stimulated ERK activation remained unaffected . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Contrasting calcium dependencies of SAPK and ERK activations by glutamate in cultured striatal neurons . ^^^ However , SAPK and ERK can also be coordinately activated in neurons in response to glutamate stimulation of NMDA receptors . ^^^ To explore the mechanisms of these MAPK activations , we compared the ionic mechanisms mediating SAPK and ERK activations by glutamate . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate stimulated calcium activation of Ras / Erk pathway mediated by nitric oxide . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Our data suggest that increased expression of genes encoding the following proteins are involved in oligodendroglial differentiation : Fyn , Erk , p 85 , G alpha 12 guanine nucleotide binding , and transducin beta 2 signal transduction molecules ; glial maturation factor ; the proteasomal subunits C 8 and C 3 ; the proteasomal targeting molecule polyubiquitin ; the cell cycle regulatory proteins Set , protein phosphatase 2A , and nuclear tyrosine phosphatase ( PRL 1 ) ; and the high affinity glutamate cotransporter EAAC 1 . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this paper , the functional effects of IL 6 on the spread of excitation visualized by dark field / infrared videomicroscopy in rat cortical slices and on glutamate release from cortical synaptosomes were analysed and correlated with the activation of the STAT 3 , mitogen activated protein kinase ERK ( MAPK / ERK ) and stress activated protein kinase / cJun NH 2 terminal kinase ( SAPK / JNK ) pathways . ^^^ We have found that IL 6 depresses the spread of excitation and evoked glutamate release in the cerebral cortex , and that these effects are accompanied by a stimulation of STAT 3 tyrosine phosphorylation , an inhibition of MAPK / ERK activity , a decreased phosphorylation of the presynaptic MAPK / ERK substrate synapsin 1 and no detectable effects on SAPK / JNK . ^^^ The inhibitory effects of IL 6 on glutamate release and on the spread of excitation in the rat cerebral cortex indicate that the protective effect of IL 6 on neuronal survival could be mediated by a downregulation of neuronal activity , release of excitatory neurotransmitters and MAPK / ERK activity . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Persistent activation of ERK contributes to glutamate induced oxidative toxicity in a neuronal cell line and primary cortical neuron cultures . ^^^ Furthermore , we find that U 0126 , a specific inhibitor of the ERK activating kinase , MEK 1 / 2 , protects both HT 22 cells and immature primary cortical neuron cultures from glutamate toxicity . ^^^ Glutamate induced ERK activation requires the production of specific arachidonic acid metabolites and appears to be downstream of a burst of reactive oxygen species ( ROS ) accumulation characteristic of oxidative stress in HT 22 cells . ^^^ However , inhibition of ERK activation reduces glutamate induced intracellular Ca ( 2+ ) accumulation . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Activation of pp 60 ( c Src ) kinase and phosphorylation of ERK were observed in response to glutamate treatment . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , we show that a novel MAPK / ERK kinase ( MEK ) specific inhibitor U 0126 profoundly protected HT 22 cells against oxidative stress induced by glutamate , which was accompanied by an inhibition of phosphorylation of ERK1 / 2 . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate receptors of NMDA subtypes also participated in ERK activation , as shown after injection of the NMDA receptor antagonist MK 801 . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The members of the mitogen activated protein ( MAP ) kinase family p44 / p42 MAP kinase ( ERK ) , c jun N terminal kinase ( JNK ) and p 38 MAP kinase ( p 38 ) are known to be important mediators of the physiological plasticity or neurotoxicity induced in the striatum by activation of ionotropic glutamate receptors . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Inhibitor analysis as well as immunochemical characterization has indicated that the MEK ( MAPK / ERK kinase ) ERK ( extracellular signal regulated kinase ) cascade plays an indispensable role in glutamate stimulated induction of Homer 1a mRNA . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These changes are accompanied by increased activation of one member of the family of mitogen activated protein kinases , extracellular signal regulated kinase ( ERK ) and the data indicate that these events play a role in modulating release of glutamate from perforant path granule cell synapses , because the Trk inhibitor K252a and the ERK inhibitor , UO 126 , both inhibited the BDNF induced enhancement of release . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| DA D 2 and glutamate receptors of NMDA subtypes also participate , albeit to a lesser extent , to THC induced ERK activation in the striatum , as shown after injection of selective antagonists ( raclopride and MK 801 , respectively ) . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This process follows the stimulation of both N methyl D aspartate and metabotropic glutamate receptors and involves the activation of the mitogen activated protein kinase ERK via protein kinase C . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To evaluate putative roles of group 1 metabotropic glutamate receptors ( mGluRs ) in CREB , Elk 1 , and ERK phosphorylation , the group 1 selective agonist , 3 , 5 dihydroxyphenylglycine ( DHPG ) , was infused into the dorsal striatum at doses of 125 , 250 , or 500 nmol in freely moving rats . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors control phosphorylation of CREB , Elk 1 and ERK via a CaMKII dependent pathway in rat striatum . ^^^ In vivo activation of group 1 metabotropic glutamate receptors ( mGluRs ) upregulates phosphorylation of cyclic AMP response element binding protein ( CREB ) , Elk 1 and extracellular signal regulated kinases ( ERK ) in striatal neurons . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Stimulation of glutamate receptors with 100 microM kainate or 100 microM glutamate for 2 min was sufficient to induce the activation of the extracellular signal regulated kinase ( ERK ) . ^^^ Inhibition of the ERK activation with the MEK inhibitors U 0126 and PD 98059 increased the toxicity induced by kainate but was without effect on the toxicity induced by glutamate . ^^^ These results indicate that , although stimulation with both glutamate receptor agonists increased ERK phosphorylation , only kainate induced ERK activation correlates with the activation of a survival signaling pathway . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In order to investigate a role for the extracellular signal regulated kinases 1 and 2 ( ERK1 / 2 ) on hippocampal neurotransmitter release , we studied the effect of commonly used MEK ( mitogen activated protein kinase [ MAPK ] / ERK kinase ) inhibitors , PD 098 , 059 and U 0126 , on depolarization induced glutamate release . ^^^ U 0126 , however , did not significantly affect KCl evoked glutamate release at concentrations shown to inhibit ERK activity . ^^^ PD 098 , 029 and U 0126 showed a small dose dependent inhibitory effect on ionomycin induced glutamate release , at concentrations shown to inhibit ionomycin stimulated ERK phosphorylation . ^^^ These findings uncover new unspecific actions for both MEK inhibitors and suggest a minor role for ERK in modulating glutamate release in the hippocampus . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate release was also enhanced , and the data suggest that this may be a consequence of increased activation of TrkB and ERK . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Reintroduction of wild type Tob and mutant Tob with serine to alanine but not to glutamate mutations on the Erk phosphorylation sites in these cells restores the suppression of cyclin D 1 expression . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Moreover , FGF 1 protection against glutamate toxicity was dependent on GSK3beta inactivation by the PI3K Akt but was independent of ERK . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors , mGlu1a and mGlu5a , couple to extracellular signal regulated kinase ( ERK ) activation via distinct , but overlapping , signalling pathways . ^^^ The coupling of the group 1 metabotropic glutamate receptors , mGlu1a and mGlu5a , to the extracellular signal regulated protein kinase ( ERK ) pathway has been studied in Chinese hamster ovary cell lines where receptor expression is under inducible control . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We used an immunocytochemical approach to examine ERK activation by muscarinic acetylcholine ( mAChR ) , metabotropic glutamate ( mGluR ) , and beta adrenergic ( beta AR ) receptors in CA 1 neurons of mouse hippocampal slices . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Finally , the effects of cannabinoids on ERK activation were dependent on the activity of glutamate NMDA receptors in vivo , but not in hippocampal slices , indicating the existence of several pathways linking CB 1 R to the ERK cascade . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Erk activation is required for Nrf 2 nuclear localization during pyrrolidine dithiocarbamate induction of glutamate cysteine ligase modulatory gene expression in HepG 2 cells . ^^^ Pyrrolidine dithiocarbamate ( PDTC ) induction of the human glutamate cysteine ligase modulatory ( GCLM ) gene is dependent on activation of the mitogen activated protein kinases ( MAPKs ) extracellular regulated kinase ( Erk ) and p 38 , and is not affected by protein kinase C ( PKC ) or PI3K inhibitors . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We have recently found that Alzheimer ' s disease amyloid beta protein ( Abeta ) activates the extracellular signal regulated kinase ( ERK ) and promotes L glutamate uptake in astrocytes . ^^^ To elucidate the relationship between the Abeta induced ERK phosphorylation and promotion of L glutamate uptake , we investigated the effects of U 0126 and PD 98059 , specific inhibitors of the ERK activating enzyme MEK , in cultured rat cortical astrocytes . ^^^ Abeta induced ERK phosphorylation was completely blocked by the MEK inhibitors , while Abeta induced promotion of extracellular L glutamate clearance was enhanced by the presence of the MEK inhibitors . ^^^ The effective concentrations of MEK inhibitors in enhancing Abeta induced promotion of glutamate clearance and GLAST expression were consistent with those in blocking Abeta induced ERK phosphorylation . ^^^ These results suggest that the MEK / ERK signal functions to suppress Abeta induced upregulation of a glutamate uptake system in astrocytes . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Exogenous nitric oxide ( NO ) donors ( S nitroso N acetyl DL penicillamine and ( E ) 4 ethyl 2 [ ( E ) hydroxyimino ] 5 nitro 3 hexenamide ) and simultaneous application of high potassium and glutamate led to the phosphorylation of extracellular signal regulated kinase ( ERK ) 1 / 2 in cerebellar Purkinje cells . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of ERK1 / 2 induced by TPA and co application of high potassium and glutamate was greatly attenuated by preincubating Purkinje cells with the MEK1 / 2 ( MAPK ERK kinase 1 / 2 ) inhibitor PD 98059 . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Glutamate transmission via NMDA and mGluR 1 but not AMPA receptors was critical to this ERK activation . ^^^ In conclusion , glutamate and BDNF are the important C fiber signaling components for ERK activation in dorsal horn neurons . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The NMDA receptor is coupled to the ERK pathway by a direct interaction between NR2B and RasGRF 1 . ^^^ The specific association of RasGRF 1 with the NR2B subunit and study of ERK activation in neurons with varied content of NR2B suggests that NR2B containing channels are the dominant activators of the NMDA dependent ERK pathway . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We have previously determined that glutamate induced oxidative toxicity is accompanied by a robust increase in activation of the mitogen activated protein kinase ( MAPK ) member extracellular signal regulated kinase ( ERK ) and that this activation is essential for neuronal cell death . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Developmentally regulated role for Ras GRFs in coupling NMDA glutamate receptors to Ras , Erk and CREB . p 140 Ras GRF 1 and p 130 Ras GRF 2 constitute a family of calcium / calmodulin regulated guanine nucleotide exchange factors that activate the Ras GTPases . ^^^ Studies on mice lacking these exchange factors revealed that both p 140 Ras GRF 1 and p 130 Ras GRF 2 couple NMDA glutamate receptors ( NMDARs ) to the activation of the Ras / Erk signaling cascade and to the maintenance of CREB transcription factor activity in cortical neurons of adult mice . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These results suggest that glutamate released from corticostriatal afferents modulates the ability of amphetamine to engage striatopallidal neurons through an ERK / MAPK signaling dependent mechanism . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In the present study we found that the epidermal growth factor activated ERK 2 in cerebellar granule neurons and that this activation prohibited glutamate induced subcellular translocation of NGFI B . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In young rats , BDNF LTP was accompanied by increased activation of the BDNF receptor TrkB , and extracellular signal regulated kinase ( ERK ) , as well as enhanced evoked release of glutamate in synaptosomes prepared from DG . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here we investigated the interaction between NMDA receptors and metabotropic glutamate receptor 5 ( mGluR 5 ) in the integral regulation of extracellular signal regulated protein kinase ( ERK ) and gene expression in cultured rat striatal neurons . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Regulation of a protein phosphatase cascade allows convergent dopamine and glutamate signals to activate ERK in the striatum . ^^^ Here , we show in mouse that d amphetamine activates ERK in a subset of medium size spiny neurons of the dorsal striatum and nucleus accumbens , through the combined action of glutamate NMDA and D 1 dopamine receptors . ^^^ Thus , activation of ERK , by a multilevel protein phosphatase controlled mechanism , functions as a detector of coincidence of dopamine and glutamate signals converging on medium size striatal neurons and is critical for long lasting effects of drugs of abuse . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Influx of calcium , mediated either by L type voltage sensitive calcium channels or glutamate receptors , is associated with the suppression of brain derived neurotrophic factor ( BDNF ) activation of Ras and its effectors Erk and Akt . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NMDA and TrkB receptor activation thus converge on the extracellular signal regulated kinase ( ERK ) 1 / 2 signaling pathway to protect neurons against glutamate mediated excitotoxicity . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To examine the intracellular signaling pathways involved in this NR2B gene transcription , we have subjected fetal cortical neurons to long term treatment with ethanol and studied its effect on cAMP response element binding protein ( CREB ) and extracellular signal regulated kinase ( ERK ) levels by Western blot and enzyme linked immunosorbent assay . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Neuroprotection by BDNF against glutamate induced apoptotic cell death is mediated by ERK and PI 3 kinase pathways . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Of interest , N methyl d aspartate ( NMDA ) , non NMDA and metabotropic glutamate receptor antagonists all blocked Hcy induced ERK activation . ^^^ Thus , altogether these data support a role of Hcy on ERK activation , via complex mechanisms , starting with a control of glutamate release , which in turn activates ionotropic and metabotropic receptor subtypes and produces increases in intracellular calcium levels . . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Differential roles of NR2A and NR2B containing NMDA receptors in Ras ERK signaling and AMPA receptor trafficking . ^^^ In mature neurons , NR2B is coupled to inhibition rather than activation of the Ras ERK pathway , which drives surface delivery of GluR 1 . ^^^ Moreover , the synaptic Ras GTPase activating protein ( GAP ) SynGAP is selectively associated with NR2B NMDARs in brain and is required for inhibition of NMDAR dependent ERK activation . ^^^ Preferential coupling of NR2B to SynGAP could explain the subtype specific function of NR2B NMDARs in inhibition of Ras ERK , removal of synaptic AMPARs , and weakening of synaptic transmission . . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RESULTS : ( 1 ) Par 4 AS ODN significantly suppressed up regulation of the par 4 protein levels induced by glutamate in PC 12 cells . ( 2 ) Par 4 AS ODN could resist the decrease of phosphorylated ERK ( 1 / 2 ) ( Thr202 / Tyr204 ) induced by glutamate in PC 12 cells . ( 3 ) Par 4 AS ODN could inhibit apoptosis of PC 12 cells induced by glutamate . ^^^ CONCLUSION : Par 4 AS ODN may inhibit apoptosis of PC 12 cells induced by glutamate , and its inhibition effects may be medicated by the activation of ERK ( 1 / 2 ) . . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We propose two independent neuronal death pathways by tributyltin ; one is glutamate receptor dependent cell death via ERK phosphorylation , and the other may be glutamate receptor independent cell death via p 38 activation . . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Age dependent participation of Ras GRF proteins in coupling calcium permeable AMPA glutamate receptors to Ras / Erk signaling in cortical neurons . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Here , we demonstrate that glutamate and substance P ( SP ) , two principal mediators of sensory information between primary afferent fibers and the spinal cord , activate Erk in dorsal horn neurons of both adult rat and mouse spinal cord . ^^^ In genetic knock out mice of calcium calmodulin stimulated adenylyl cyclase subtypes 1 ( AC 1 ) and 8 ( AC 8 ) , activation of Erk in dorsal horn neurons were significantly reduced or blocked , either after peripheral tissue inflammation or by glutamate or SP in spinal cord slices . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This procedure also abolished the phosphorylation of ERK and glutamate receptor 1 observed in the ventral and dorsal striatum , 24 h later , during CPP test . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The small effect of BDNF on [ ( 3 ) H ] glutamate release correlated with a modest increase in phospholipase Cgamma ( PLCgamma ) phosphorylation , and with the lack of effect of BDNF on extracellular signal regulated kinase ( ERK ) and Akt phosphorylation . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Group 1 metabotropic glutamate receptors activate the p70S6 kinase via both mammalian target of rapamycin ( mTOR ) and extracellular signal regulated kinase ( ERK 1 / 2 ) signaling pathways in rat striatal and hippocampal synaptoneurosomes . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| As a result , simultaneous activation of both extrasynaptic and synaptic NMDAR using bath application of NMDA or glutamate ( a typical protocol explored in the majority of studies ) produced ERK activation that depended on the concentration of agonists and was always significantly weaker than those mediated by synaptic NMDARs . ^^^ Since the activation of the extrasynaptic NMDA is attributed mainly to global release of glutamate occurring at pathological conditions including hypoxic / ischaemic insults , traumas and epileptic brain damage , the reported differential regulation of ERK cascade by NMDARs provides a unique mechanism for an early identification of the physiological and / or pathophysiological consequences of NMDAR activation . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Involvement of ERK and CREB signaling pathways in the protective effect of PACAP in monosodium glutamate induced retinal lesion . ^^^ |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Furthermore , Numb formed a complex with EphB 2 receptor type tyrosine kinase and NMDA type glutamate receptors . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Expression of the cefG gene from the promoters of ( 1 ) the glyceraldehyde 3 phosphate dehydrogenase ( gpd ) gene of Aspergillus nidulans , ( 2 ) the glucoamylase ( gla ) gene of Aspergillus niger , ( 3 ) the glutamate dehydrogenase ( gdh ) and ( 4 ) the isopenicillin N synthase ( pcbC ) genes of Penicillium chrysogenum , led to very high steady state levels of cefG transcript and to increased deacetylcephalosporin C acetyltransferase protein concentration ( as shown by immunoblotting ) and enzyme activity in the transformants . ^^^ |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P29323 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|