| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We also identify multiple accessory proteins associated with vesicle trafficking , including munc 18 , rSec 8 , DOC 2 , syntaxin 6 , and synaptophysin , which have varied roles in regulated glutamate exocytosis . mRNA for the putative Ca ( 2+ ) dependent regulators of vesicle recycling activity , synaptotagmin 1 ( specialized for fast Ca ( 2+ ) dependent exocytosis as seen in synaptic neurotransmission ) , and the GTP binding protein Rab3A are also identified by northern blot analysis . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Consistent with this hypothesis , three vesicle proteins critical for calcium mediated exocytosis , synaptotagmin 1 , cysteine string protein , and neuronal synaptobrevin , are all mislocalized to the extrasynaptic axonal regions along with Dap 160 , an active zone marker ( nc 82 ) , and glutamate receptors in the mutant . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| RESULTS : 18 protein spots were differentially expressed as compared with age matched nondemented control brains which were identified as glyceraldehyde 3 phosphate dehydrogenase , uracil DNA glycosylase , human superoxide dismutase , isocitrate dehydrogenase subunit , synaptotagmin 1 , thioredoxin peroxidase 1 , glial fibrillary acidic protein , p 25 alpha , enoyl coenzyme A hydratase short chain 1 , pyridoxine 5 ' phosphate oxidase , Mn superoxide dismutase and alpha enolase , antioxidant protein 2 , ferritin heavy chain , glutamate dehydrogenase precursor , peptidyl prolyl cis trans isomerase A , serum albumin precursor and dihydropyrimidinase related protein 2 . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Interestingly , the properties of basal neurotransmission are normal in the Mecp 2 null mice , consistent with our observations that the levels of expression of synaptic and cytoskeletal proteins , including glutamate receptor subunits GluR 1 and GluR 2 , PSD 95 , synaptophysin 1 , synaptobrevin 2 , synaptotagmin 1 , MAP 2 , betaIII tubulin and NF 200 , are not significantly altered . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We now show that in cultured cortical neurons stimulated at low frequency ( < or . 1 Hz ) , deletion of synaptotagmin 1 blocks synchronous GABA and glutamate release without significantly increasing asynchronous release . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We then show that podocytes possess structures resembling synaptic vesicles , which contain glutamate , coexpress Rab3A and synaptotagmin 1 , and undergo spontaneous and stimulated exocytosis and recycling , with glutamate release . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Reduction of Syt 4 in astrocytes by RNA interference decreases Ca ( 2+ ) dependent glutamate release , a gliotransmission pathway that regulates synaptic transmission . ^^^ Mutants of the C2B domain , the only putative Ca ( 2+ ) binding domain in Syt 4 , act in a dominant negative fashion over Ca ( 2+ ) regulated glial glutamate release , but not gliotransmission induced by changes in osmolarity . ^^^ |
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| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P21579 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|