| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The primary structure showed a high homology with the metabotropic glutamate receptors ( mGluR ) , and a limited homology with the Ca2+ / polyvalent cation receptors ( CaR ) . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| GDNF also protected striatal CaR positive neurons against glutamate toxicity . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| The calcium sensing receptor ( CaR ) is a G protein coupled receptor that displays 19 25 % sequence identity to the gamma aminobutyric acid type B ( GABAB ) and metabotropic glutamate ( mGlu ) receptors . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In addition , the role of dopamine ( DA ) D 2 , serotonin ( 5 HT ) 2A / 2C , alpha 1 , 5 HT1A , DA D 4 , muscarinic and glutamate receptors in the suppression of CAR induced by various classes of drugs is evaluated . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Structurally , the CaR is a novel member of a growing G protein coupled receptor superfamily , which includes metabotropic glutamate receptors ( mGluRs ) [ 1 ] , [ gamma ] aminoisobutyric acid ( GABA B ) receptors [ 2 ] and vomeronasal organ receptors [ 3 ] . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| This constitutive activity was not diminished when the mutations were transferred to a chimeric receptor Ca / 1a consisting of the amino terminal domain of the CaR and the 7 transmembrane and intracellular domains of the metabotropic glutamate receptor mGluR1a . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| We also made use of truncation and deletion mutants of the CaR and CaR / metabotropic glutamate receptor type 1 ( mGluR 1 ) chimeras to study both the site of action of R 568 and the effect of the Leu125Pro activating mutation . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Calcium sensing ( CaR ) and Group 1 metabotropic glutamate receptors exhibit overlapping expression patterns in brain , and share common signal transduction pathways . ^^^ To determine whether CaR and Group 1 metabotropic glutamate receptors ( mGluRs ) ( mGluR1alpha and mGluR 5 ) can form heterodimers , we immunoprecipitated CaR from bovine brain and observed co precipitation of mGluR1alpha . ^^^ CaR becomes sensitive to glutamate mediated internalization when present in CaR : mGluR1alpha heterodimers . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined whether conserved amino acid residues involved in the binding of glutamate to metabotropic glutamate receptors ( mGluRs ) also participate in the potentiation of the activity of CaR by l phenylalanine . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Metabotropic glutamate receptors ( mGluRs ) and calcium receptors ( CaR ) are closely related G protein coupled receptors ( GPCRs ) . ^^^ The similar structural and functional properties of mGluRs and CaRs include conserved amino acid residues involved in glutamate binding in mGluRs and Ca2+ binding in the CaR . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| These traits , along with a significant homology to the human calcium sensing receptor ( CaR , 34 % aa sequence identity ) , the taste receptor 1 ( T1R1 , 28 % ) , and the metabotropic glutamate receptor 1 ( mGluR 1 , 24 % ) , places GPRC6A in family C of the GPCRs . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| Second , two CaR mGlu chimeric receptor constructs that retained the VFT domain of CaR , one containing the extracellular Cys rich region of CaR and the other containing the Cys rich region of the rat metabotropic glutamate type 1 ( mGlu 1 ) receptor , together with the rat mGlu 1 transmembrane region and C terminal tail , retained amino acid sensing . ^^^ The findings support the concept that the mGlu 1 amino acid binding site for L glutamate is conserved as an L amino acid binding site in its homolog , the CaR . . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| To gain an insight into the long term molecular changes involved in the above described long term nociceptive effects of neonatal noxious insult at the spinal level , we performed DNA microarray analysis ( using microarrays containing oligo probes for 205 genes encoding receptors and transporters for glutamate , GABA , and amine neurotransmitters , precursors and receptors for neuropeptides , and neurotrophins , cytokines and their receptors ) to compare gene expression profiles in the lumbar spinal dorsal horn ( LDH ) of adult ( P 60 ) male rats that received neonatal CAR treatment within ( at postnatal day 3 ; P 3 ) and outside ( at postnatal 12 ; P 12 ) of the sensitive period . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| In mammals , the CNC family members nuclear factor erythroid 2 p 45 related factors 1 and 2 ( Nrf 1 and Nrf 2 ) have been shown to be involved in the transcriptional up regulation of cytoprotective genes including those encoding glutamate cysteine ligase , NAD ( P ) H : quinone oxidoreductase , glutathione S transferases and aldo keto reductases . ^^^ |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: P10644 and Q13224 |
Pubmed |
SVM Score :0.0 |
| NA |
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