| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 2 , a novel member of the neuropilin family , is a high affinity receptor for the semaphorins Sema E and Sema 4 but not Sema 3 . ^^^ Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Sema K 1 does not bind to neuropilin 1 or neuropilin 2 , the two receptors implicated in mediating the repulsive action of several secreted semaphorins , and thus it likely acts through a novel receptor . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Here , we show that neuropilin 2 is a receptor for the secreted semaphorin Sema 4 and acts selectively to mediate repulsive guidance events in discrete populations of neurons . neuropilin 2 and semaIV are expressed in strikingly complementary patterns during neurodevelopment . ^^^ The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NrCAM , an immunoglobulin superfamily adhesion molecule of the L 1 subfamily , associates with neuropilin 2 and is a component of a receptor complex for Sema3B and Sema3F . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 2 ( NRP 2 ) is a receptor for the vascular endothelial growth factor ( VEGF ) and the semaphorin ( SEMA ) families , 2 unrelated ligand families involved in angiogenesis and neuronal guidance . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| SemA and SemE seem to have a newly discovered protein antagonist capacity at NP 1 receptors , whereas they act as agonists at receptors containing NP 2 . . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| By contrast , VEGF 121 , a VEGF variant that lacks binding to neuropilin ( NP ) 1 or NP 2 receptors , was not expressed in tumor cells and had no effect on SEMA3B growth suppressing activities . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| The embryonic septum expressed np 1 and np 2 mRNAs , and the striatum and cerebral cortex expressed sema 3A and sema 3F . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that the temporal up regulation of Npn 1 and Sema 3A mRNA expressions in the non infarcted parietal cortex on the lesion side is insufficient to induce neuronal cell death possibly because the up regulated mRNA molecules are not fully translated and that the overexpression of Npn 1 and / or Npn 2 in the ischemic core with degenerating neurons enables activated microglial cells to contact the damaged neurons in situ for phagocytosis . . ^^^ |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: O60462 and Q13214 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 2 , a novel member of the neuropilin family , is a high affinity receptor for the semaphorins Sema E and Sema 4 but not Sema 3 . ^^^ Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Sema K 1 does not bind to neuropilin 1 or neuropilin 2 , the two receptors implicated in mediating the repulsive action of several secreted semaphorins , and thus it likely acts through a novel receptor . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| SemA and SemE seem to have a newly discovered protein antagonist capacity at NP 1 receptors , whereas they act as agonists at receptors containing NP 2 . . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| These findings suggest that the temporal up regulation of Npn 1 and Sema 3A mRNA expressions in the non infarcted parietal cortex on the lesion side is insufficient to induce neuronal cell death possibly because the up regulated mRNA molecules are not fully translated and that the overexpression of Npn 1 and / or Npn 2 in the ischemic core with degenerating neurons enables activated microglial cells to contact the damaged neurons in situ for phagocytosis . . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| The embryonic septum expressed np 1 and np 2 mRNAs , and the striatum and cerebral cortex expressed sema 3A and sema 3F . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 2 ( NRP 2 ) is a receptor for the vascular endothelial growth factor ( VEGF ) and the semaphorin ( SEMA ) families , 2 unrelated ligand families involved in angiogenesis and neuronal guidance . ^^^ Neuropilin 2 ( NRP 2 ) is a receptor for the vascular endothelial growth factor ( VEGF ) and the semaphorin ( SEMA ) families , 2 unrelated ligand families involved in angiogenesis and neuronal guidance . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| By contrast , VEGF 121 , a VEGF variant that lacks binding to neuropilin ( NP ) 1 or NP 2 receptors , was not expressed in tumor cells and had no effect on SEMA3B growth suppressing activities . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Here , we show that neuropilin 2 is a receptor for the secreted semaphorin Sema 4 and acts selectively to mediate repulsive guidance events in discrete populations of neurons . neuropilin 2 and semaIV are expressed in strikingly complementary patterns during neurodevelopment . ^^^ The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NrCAM , an immunoglobulin superfamily adhesion molecule of the L 1 subfamily , associates with neuropilin 2 and is a component of a receptor complex for Sema3B and Sema3F . ^^^ |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O60462 |
Pubmed |
SVM Score :0.0 |
| NA |
|