| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin ( neuropilin 1 ) was recently identified as a receptor for Collapsin 1 / Semaphorin III / D ( Sema 3 ) . ^^^ Unlike neuropilin 1 , which binds with high affinity to the three structurally related semaphorins Sema 3 , Sema E , and Sema 4 , neuropilin 2 shows high affinity binding only to Sema E and Sema 4 , not Sema 3 . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Sema K 1 does not bind to neuropilin 1 or neuropilin 2 , the two receptors implicated in mediating the repulsive action of several secreted semaphorins , and thus it likely acts through a novel receptor . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| The secreted semaphorins Sema 3 and Sema 4 and their receptors Neuropilin 1 and 2 are expressed in the hippocampal formation during appropriate stages . ^^^ An antibody against Neuropilin 1 blocks the repulsive action of Sema 3 and the entorhinal cortex , but has no effect on Sema 4 induced repulsion . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and neuropilin 2 show specificity in binding to different class 3 semaphorins , including Sema 3 , Sema E , and Sema 4 , suggesting that the specificity of action of these semaphorins is dictated by the complement of neuropilins expressed by responsive neurons . ^^^ In support of this , we show that sympathetic axons coexpress neuropilin 1 and 2 , that their responses to Sema 3 , Sema E , and Sema 4 are affected in predicted ways by antibodies to neuropilin 1 , and that neuropilin 1 and 2 can form homo and heterooligomers through an interaction involving at least partly the neuropilin MAM ( meprin , A 5 , mu ) domain . ^^^ These results support the idea that in sympathetic axons , the Sema 3 signal is mediated predominantly by neuropilin 1 oligomers , the Sema 4 signal by neuropilin 2 oligomers , and the Sema E signal by neuropilin 1 and 2 , either as homo or heterooligomers . . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Here we report the effect of peripheral nerve injury on the expression of the genes encoding sema III / coll 1 and its receptor neuropilin 1 , which are known to be expressed in adult sensory and / or motor neurons . ^^^ No changes were observed in neuropilin 1 mRNA levels after injury to sensory and motor neurons , suggesting that regenerating peripheral neurons continue to be sensitive to sema III / coll 1 . ^^^ Therefore we propose that a decreased expression of sema III / coll 1 , one of the major ligands for neuropilin 1 , during peripheral nerve regeneration is an important molecular event that is part of the adaptive response related to the success of regenerative neurite outgrowth occurring following peripheral nerve injury . . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| To explore a role for chemorepulsive axon guidance mechanisms in the regeneration of primary olfactory axons , we examined the expression of the chemorepellent semaphorin 3 ( sema 3 ) , its receptor neuropilin 1 , and collapsin response mediator protein 2 ( CRMP 2 ) during regeneration of the olfactory system . ^^^ Sema 3 mRNA is expressed in pial sheet cells and in second order olfactory neurons that are the target cells of neuropilin 1 positive primary olfactory axons . ^^^ In contrast to the transient appearance of sema 3 positive cells at the lesion site after axotomy , sema 3 positive cells increase progressively after bulbectomy , apparently preventing regenerating neuropilin 1 positive nerve bundles from growing deeper into the lesion area . ^^^ The presence of sema 3 in scar tissue and the concomitant expression of its receptor neuropilin 1 on regenerating olfactory axons suggests that semaphorin mediated chemorepulsive signal transduction may contribute to the regenerative failure of these axons after bulbectomy . . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 is a receptor for Sema 3 . ^^^ The extracellular complement binding ( CUB ) and coagulation factor domains of neuropilin 2 confer specificity to the Sema 4 repulsive response , and these domains of neuropilin 1 are necessary and sufficient for binding of the Sema 3 semaphorin ( sema ) domain . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 , a sema 3 receptor , was expressed in injured neurons with projections to the lesion site , in a subpopulation of scar associated cells and in blood vessels around the scar . ^^^ The concomitant expression of sema 3 and its receptor neuropilin 1 in the scar suggests that sema III / neuropilin 1 mediated mechanisms are involved in CNS scar formation . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( Npn 1 ) is a receptor that binds multiple ligands from structurally distinct families , including secreted semaphorins ( Sema ) and vascular endothelial growth factors ( VEGF ) . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 ( NRP 1 ) is a coreceptor to a tyrosine kinase receptor for both the vascular endothelial growth factor ( VEGF ) family and semaphorin ( Sema ) family members . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilin 1 and Plexin A 1 are cell surface proteins that form a receptor complex for Semaphorin 3A ( Sema 3A ) , a secreted molecule mediating repelling signals for axonal growth cones . ^^^ We also found that Sema 3A receptors , Neuropilin 1 and Plexin A 1 , are expressed by the nervous fibers of the proximal part of the umbilical cord , whereas Sema 3A is secreted in the umbilical cord , in the placenta , and in gestational uterine tissues . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Neuropilins ( NRP ) are membranous receptors capable of binding two disparate ligands , class 3 semaphorins ( SEMA ) and vascular endothelial growth factors ( VEGF ) , and regulating two diverse systems , neuronal guidance and angiogenesis . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| Following up on that initial observation , we have now used real time quantitative reverse transcription polymerase chain reaction to demonstrate induction of genes encoding neuropilin 1 ( NP 1 ) , which , like NP 2 , serves as a coreceptor for members of the class 3 semaphorin family of axonal guidance molecules and of five of the six known class 3 semaphorins ( Sema3A , Sema3B , Sema3C , Sema3E , and Sema3F , but not Sema3D ) in crushed or transected sciatic nerves . . ^^^ |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13214 and O14786 |
Pubmed |
SVM Score :0.0 |
| NA |
|