| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| Rac 1 exerts its effects in the epidermis by negatively regulating c Myc through p 21 activated kinase 2 ( PAK 2 ) phosphorylation . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| The dissociation constants of the p 21 binding domains of PAK 1 , PAK 2 , and the RasGAP related domain of IQGAP 1 , which all cause significant reduction of the intrinsic rate of GTP hydrolysis upon binding to Rac 1 GTP , are found to be 0 . 71 , 0 . 26 , and 2 . 13 microM for Rac 1 GTP , compared with that determined for Cdc 42 GTP at 2 . 9 , 20 . 5 , and 0 . 39 microM , respectively , under similar conditions . ^^^ These results suggest that p50RhoGAP , p 190 , Bcr , and 3BP 1 are all capable of acting as a negative regulator for Rac 1 mediated signaling , and that , although PAK 1 and IQGAP 1 can couple tightly with both Rac 1 and Cdc 42 , PAK 2 is likely to be a specific effector for Rac 1 instead of Cdc42 . . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| We show that the small GTPase Cdc 42 is required for maintenance of active endogenous 10 PAK 2 in resting stage 6 oocytes , whereas Rac 1 is not involved in this regulation . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| Inhibition of ERK or PAK 2 , the kinases upstream of p 85 betaPIX in the bFGF signaling , prevents Rac 1 activation , suggesting that phosphorylation of p 85 betaPIX functions upstream of Rac 1 activation . ^^^ Both wild type and mutant p 85 betaPIX displaying negative GEF activity ( L238R / L239S ) are similarly recruited to growth cones , suggesting that Rac 1 activation is not essential for translocation of the PIX complex ( PAK 2 p85 betaPIX Rac 1 ) . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| Furthermore , we show that TGF beta stimulated PAK 2 activity is regulated by Rac 1 and Cdc 42 and dominant negative PAK 2 or morpholino antisense oligonucleotides to PAK 2 prevent the morphological alteration observed following TGF beta addition . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| In agreement , silencing of Rac 1 by shRNA blocks PAK 2 activity and inhibits RANTES / CCL5 induced macrophage polarization and directional migration . ^^^ Our results thus demonstrate a chemokine specific signaling pathway in which Gi and PI3Kgamma coordinate to drive Rac 1 and PAK 2 activation that eventually controls the chemotactic response . . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| Interestingly , unlike PAK 65 , HPK 1 does not contain the small GTPase Rac1 / Cdc42 binding domain and does not bind to either Rac 1 or Cdc 42 , suggesting that HPK 1 . activation is Rac1 / Cdc42 independent . ^^^ |
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| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P63000 |
Pubmed |
SVM Score :0.0 |
| NA |
|