| Binding of activated alpha 2 macroglobulin to its cell surface receptor GRP 78 in 1 LN prostate cancer cells regulates PAK 2 dependent activation of LIMK . ^^^ PAK 2 activation was accompanied by significant increases in the levels of phosphorylated LIMK and phosphorylated cofilin . ^^^ Silencing the expression of the PAK 2 gene greatly attenuated the phosphorylation of LIMK . ^^^ |