| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.8540145 |
| Surprisingly , PAK 2 directly binds to ERK , and its activation is dependent on ERK . p 85 betaPIX specifically localizes to the lamellipodia at neuronal growth cones in response to bFGF . 0.8540145^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| This event was marked by the induction of several protein kinases such as phosphatidylinositol 3 kinase ( PI3K ) , phosphorylated protein kinase B ( PKB ; also known as Akt ) , p 21 activated kinase 2 ( PAK 2 ) , and their downstream effector ( ERK ) as well as an increase in PKB intrinsic activity . ^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| We find that overexpression of the Ste 20 related enzymes p 21 activated kinase 1 ( PAK 1 ) and PAK 2 in 293 cells is sufficient to activate JNK / SAPK and to a lesser extent p 38 MAP kinase but not ERK 2 . ^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| Inhibition of ERK or PAK 2 , the kinases upstream of p 85 betaPIX in the bFGF signaling , prevents Rac 1 activation , suggesting that phosphorylation of p 85 betaPIX functions upstream of Rac 1 activation . ^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| This effort has led to nanomolar to micromolar inhibitors of 11 new targets including p90RSK , KDR , c Kit , Fes , MAPK 1 , PAK 2 , PDK 1 , PKCtheta , PKD 2 , Rsk 1 , and SGK . ^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation of Erk 2 activated Mnk 1 by Pak 2 has no effect on phosphorylation of eIF4E but reduces phosphorylation of eIF4G by Mnk 1 by up to 50 % . ^^^ |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13177 and P28482 |
Pubmed |
SVM Score :0.0 |
| NA |
|