| Interacting proteins: Q13177 and P16333 |
Pubmed |
SVM Score :0.0 |
| The small GTPase Cdc 42 , its inhibitory subunit Rho GDI , the adapter protein Nck , gamma p 21 activated protein kinase ( gamma Pak ) , and cofilin were found to undergo rapid association with the developing phagosomes in these cells . ^^^ |
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| Interacting proteins: Q13177 and P16333 |
Pubmed |
SVM Score :0.0 |
| Human immunodeficiency virus type 1 Nef selectively associates with a catalytically active subpopulation of p 21 activated kinase 2 ( PAK 2 ) independently of PAK 2 binding to Nck or beta PIX . ^^^ Binding of PAK 2 with the adapter protein Nck or beta PIX was found to be dispensable for the assembly of the Nef PAK 2 complex , whereas an intact Cdc 42 Rac1 interactive binding motif was required . ^^^ |
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| Interacting proteins: Q13177 and P16333 |
Pubmed |
SVM Score :0.0 |
| Phosphorylation within the activation loop ( Thr ( 402 ) ) and inhibitory domain ( Ser ( 141 ) ) is known to increase the activity of Pak in vitro , whereas phosphorylation within the Nck ( Ser ( 20 ) ) and Pak interacting guanine nucleotide exchange factor ( Ser ( 192 ) and Ser ( 197 ) ) binding sites blocks the interactions of Pak 2 with these proteins . ^^^ |
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| Interacting proteins: Q13177 and P16333 |
Pubmed |
SVM Score :0.0 |
| Treatment of 1 LN cells with alpha2M * caused translocation of PAK 2 in association with NCK to the cell surface as evidenced by the co immunoprecipitation of PAK 2 and NCK in the GRP 78 immunoprecipitate from plasma membranes . alpha2M * induced activation of PAK 2 was inhibited by prior incubation of the cells with specific inhibitors of tyrosine kinases and phosphatidylinositol 3 kinase . ^^^ |
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| Interacting proteins: Q13177 and P16333 |
Pubmed |
SVM Score :0.0 |
| Receptor tyrosine phosphorylation upon binding of alpha2M * to GRP 78 , recruits PAK 2 to the plasma membrane via the adaptor protein NCK . ^^^ Consistent with this hypothesis , silencing of GRP 78 gene expression greatly attenuated the levels of membrane associated PAK 2 and NCK . ^^^ |
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