| Interacting proteins: Q13177 and P00519 |
Pubmed |
SVM Score :1.0210701 |
| Functional interaction between c Abl and the p 21 activated protein kinase gamma PAK . 1.0210701^^^ We report herein that gamma PAK is associated in vivo with the nonreceptor protein tyrosine kinase c Abl . gamma PAK phosphorylates c Abl on sites located in the kinase domain , in a region that is implicated in protein protein interactions and in subcellular localization . 0.98097891^^^ In summary , we describe a functional interaction between gamma PAK and c Abl in which gamma PAK stimulates c Abl tyrosine kinase activity and c Abl phosphorylates and down regulates gamma PAK , suggesting the existence of a negative feedback loop between c Abl and gamma PAK . . 0.80877723^^^ |
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| Interacting proteins: Q13177 and P00519 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta ( TGF beta ) is the single most important cytokine promoting renal fibrogenesis . p 21 activated kinase 2 ( PAK 2 ) and activation of abelson nonreceptor tyrosine kinase ( c abl ) have been shown recently to be smad independent , fibroblast specific targets downstream of the activated TGF beta receptor . ^^^ In the current study we show that in cultured NRK49F renal fibroblasts ( but not in tubular or mesangial cells ) TGF beta similarly activates PAK 2 as well as c abl and induces cell proliferation . ^^^ Inhibition of the c abl kinase with imatinib mesylate prevents increased proliferation after TGF beta addition without affecting PAK 2 . ^^^ In obstructed kidneys , PAK 2 and c abl activity were increased but only c abl activation was blocked by imatinib . ^^^ |
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| Interacting proteins: Q13177 and P00519 |
Pubmed |
SVM Score :0.0 |
| Transforming growth factor beta activation of c Abl is independent of receptor internalization and regulated by phosphatidylinositol 3 kinase and PAK 2 in mesenchymal cultures . ^^^ Although c Abl activation by TGF beta is independent of Smad 2 or Smad 3 , it is prevented by inhibitors of phosphatidylinositol 3 kinase or PAK 2 . ^^^ Thus , c Abl represents a target downstream of phosphatidylinositol 3 kinase activated PAK 2 , which differentiates TGF beta signaling in fibroblasts and epithelial cell lines and integrates serine / threonine receptor kinases with tyrosine kinase pathways . . ^^^ |
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