| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| MEKK 3 directly regulates MEK 5 activity as part of the big mitogen activated protein kinase 1 ( BMK 1 ) signaling pathway . ^^^ Through utilization of a yeast two hybrid screen , we have identified MEKK 3 as a molecule that physically interacts with MEK 5 . ^^^ This interaction appears to take place in mammalian cells as evidenced by the fact that cellular MEK 5 and MEKK 3 co immunoprecipitate . ^^^ In addition , we show that a dominant active form of MEKK 3 stimulates BMK 1 activity through MEK 5 . ^^^ Taken together , these results identify MEKK 3 as a kinase that regulates the activity of MEK 5 and BMK 1 during growth factor induced cellular stimulation . . ^^^ |
|
| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| MEKK 2 and MEKK 3 are differentially associated with signaling from specific upstream receptor systems , whereas both activate the MEK 5 BMK1 / ERK5 pathway . . ^^^ |
|
| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| The Phox and Bem1p ( PB 1 ) domain constitutes a recently recognized protein protein interaction domain found in the atypical protein kinase C ( aPKC ) isoenzymes , lambda / iota and zeta PKC ; members of mitogen activated protein kinase ( MAPK ) modules like MEK 5 , MEKK 2 , and MEKK 3 ; and in several scaffold proteins involved in cellular signaling . ^^^ |
|
| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| PB 1 domains of MEKK 2 and MEKK 3 interact with the MEK 5 PB1 domain for activation of the ERK 5 pathway . ^^^ MEKK 2 and MEKK 3 are MAPK kinase kinases that activate the ERK 5 pathway by phosphorylating and activating the MAPK kinase , MEK 5 . ^^^ A PB 1 domain is encoded within the N terminal portion of MEKK 2 , MEKK 3 , and MEK 5 . ^^^ Herein , we analyze the functional role of MEKK 2 , MEKK 3 , and MEK 5 PB1 domains in the ERK 5 activation pathway . ^^^ The PB 1 domains of MEKK 2 and MEKK 3 bind the PB 1 domain of MEK 5 but do not significantly homo or heterodimerize with one another in vitro . ^^^ |
|
| Interacting proteins: Q13163 and Q99759 |
Pubmed |
SVM Score :0.0 |
| Here , we show that MEK 5 and big MAP kinase 1 ( BMK 1 ) function downstream of MEKK 3 in a signaling cascade that induces calcineurin activity through phosphorylation of MCIP 1 . ^^^ |
|