| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| NA |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| Identification and characterization of AMPK gamma 3 mutations in the pig . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| To determine the functional role of the AMPK gamma 3 isoform , we generated transgenic mice with skeletal muscle specific expression of wild type or mutant ( 225Q ) mouse gamma 3 as well as Prkag 3 knockout mice . ^^^ Glycogen resynthesis after exercise was impaired in AMPK gamma 3 knock out mice and markedly enhanced in transgenic mutant mice . ^^^ An AMPK activator failed to increase skeletal muscle glucose uptake in AMPK gamma 3 knock out mice , whereas contraction effects were preserved . ^^^ Our results validate the muscle specific AMPK gamma 3 isoform as a therapeutic target for prevention and treatment of insulin resistance . . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| METHODS : Two genetically modified animal models were used : AMPK gamma 3 subunit knockout mice ( Prkag 3 ( / ) ) and skeletal muscle specific transgenic mice ( Tg Prkag 3 ( 225Q ) ) that express a mutant ( R225Q ) gamma 3 subunit . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| Moreover , the AMPK gamma 3 gene was only expressed in heart and skeletal muscle . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| The muscle specific isoform of the regulatory gamma subunit of the kinase , AMPK gamma 3 , has an important role in glucose uptake , glycogen synthesis , and fat oxidation in white skeletal muscle , as previously demonstrated by physiological characterization of AMPK gamma 3 mutant ( R225Q ) transgenic ( TgPrkag 3 ( 225Q ) ) and gamma 3 knock out ( Prkag 3 ( / ) ) mice . ^^^ We determined AMPK gamma 3 dependent regulation of gene expression by analyzing global transcription profiles in glycolytic skeletal muscle from gamma 3 mutant transgenic and knock out mice using oligonucleotide microarray technology . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| The bovine PRKAG 3 gene encodes the AMPK gamma 3 subunit , one isoform of the regulatory gamma subunit of the AMP activated protein kinase ( AMPK ) . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| Here , it is shown that the mutation is a nonconservative substitution ( R200Q ) in the PRKAG 3 gene , which encodes a muscle specific isoform of the regulatory gamma subunit of adenosine monophosphate activated protein kinase ( AMPK ) . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| PRKAA 1 mapped to BTA 20 , PRKAA 2 and PRKAB 2 to BTA 3 , PRKAB 1 to BTA 17 , PRKAG 1 to BTA 5 , PRKAG 2 to BTA 4 , and PRKAG 3 to BTA 2 . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| The PRKAG 3 gene encodes the gamma 3 chain of AMP activated protein kinase ( AMPK ) . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| The PRKAG 3 gene encodes a muscle specific isoform of the regulatory gamma subunit of AMP activated protein kinase ( AMPK ) . ^^^ Comparative sequence analysis of horse , pig , mouse , human , Fugu , and zebrafish was performed to establish the exon / intron organization of horse PRKAG 3 and to study the homology among different isoforms of AMPK gamma genes in vertebrates . ^^^ |
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| Interacting proteins: Q9UGI9 and Q13131 |
Pubmed |
SVM Score :0.0 |
| A dominant mutation , denoted RN ( ) , in the porcine PRKAG 3 gene , encoding the regulatory gamma 3 subunit of AMPK , results in hyperaccumulation of glycogen in glycolytic skeletal muscle cells . ^^^ |
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