Pubmed abstracts for Protein-Protein Interaction search result :

Interacting proteins: Q13131 and P07900	Pubmed	SVM Score :0.0
However , inhibition of AMPK did not alter estradiol induced eNOS phosphorylation at serine 1177 or threonine 495 but decreased eNOS interaction with HSP 90 . ^^^ CONCLUSIONS : Taken together , these data indicate that AMPK activity is essential for estradiol induced eNOS activation via the promotion of eNOS interaction with HSP 90 . ^^^ These data point to a novel role for AMPK in modulating endothelial cell NO bioactivity and HSP 90 function . . ^^^
Interacting proteins: Q13131 and P07900	Pubmed	SVM Score :0.0
Furthermore , administration of metformin as well as 5 aminoimidazole 4 carboxamide ribonucleoside , an AMPK agonist , significantly increased eNOS Ser 1179 phosphorylation , NO bioactivity , and coimmunoprecipitation of eNOS with hsp 90 in wild type C57BL6 mice but not in AMPK alpha 1 knockout mice , suggesting that AMPK is required for metformin enhanced eNOS activation in vivo . ^^^ Taken together , our results indicate that metformin might improve vascular endothelial functions in diabetes by increasing AMPK dependent , hsp 90 mediated eNOS activation . . ^^^