| Although Rit , Rin , and Ras have highly related effector domain sequences , Rit and Rin were found to interact with the known Ras binding proteins RalGDS , Rlf , and AF 6 / Canoe but not with the Raf kinases , RIN 1 , or the p 110 subunit of phosphatidylinositol 3 kinase . ^^^ These interactions were GTP and effector domain dependent and suggest that RalGDS , Rlf , and AF 6 are Rit and Rin effectors . ^^^ |