| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.62764848 |
| The inability of MKP 2 to dephosphorylate ERK in vivo is also not due to the inability of Flag MKP 2 to bind both ERK and JNK ; phosphorylated forms of each kinase are co precipitated with both WT and CI MKP 2 . 0.62764848^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| PAC 1 , MKP 2 , and MKP 1 recognize ERK and p 38 , ERK and JNK , and ERK , p 38 , and JNK , respectively . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| In this study , we examined the actions of MKP 1 and MKP 2 on JNK 1 and JNK 2 . ^^^ JNK 1 phosphorylation and activation was inhibited by expression of both MKP 1 and MKP 2 , although MKP 1 selectivity toward JNK 1 appeared significantly higher than that of MKP 2 . ^^^ Both MKP 1 and MKP 2 were highly effective at blocking the activation of the physiological target of JNK activation , the transcription factor c Jun . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| Although MKP 2 preferentially inactivates extracellular signal regulated kinase ( ERK ) and c Jun NH ( 2 ) terminal kinase ( JNK ) MAP kinase subfamilies , the mechanisms underlying its own regulation remain unclear . ^^^ We found that the catalytic activity of MKP 2 was enhanced dramatically by ERK and JNK but was affected only minimally by p 38 . ^^^ By contrast , p 38 and ERK bound MKP 2 with comparably strong affinities , whereas JNK and MKP 2 interacted very weakly . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| Maximum induction of MKP 1 mRNA and nuclear protein levels by TNF alpha or IL 1beta were noted at 60 min and their expression correlated with the termination of JNK kinase activity , whereas nuclear levels of MKP 2 were not significantly affected by treatment with TNF alpha or IL 1beta . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| Furthermore , whilst expression of WT MKP 2 , NLS 1 or NLS 2 reduced both sorbitol or UV stimulated nuclear c Jun N terminal kinase ( JNK ) activity in HEK 293 cells , this effect was absent in cells expressing DNLS MKP 2 . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| Elevated activity of MKP 2 in alphaT 3 1 cells , through either overexpression or activation of the endogenous MKP 2 gene , was correlated with inhibition of GnRH induced activation of ERK and JNK , as well as the expression of ERK and JNK dependent proto oncogenes . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| The mitogen activated protein kinase ( MAPK ) phosphatase MKP 2 [ inactivates extracellular regulated kinase ( ERK ) = Jun N terminal kinase ( JNK ) > p 38 MAPK ] completely abrogates MMP 1 activation , whereas PAC 1 ( inactivates ERK = p 38 > JNK ) attenuates but does not completely prevent induction . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| This delayed repression of JNK was preceded by phosphorylation of the MKP 2 phosphatase , and both MKP 2 induction and JNK dephosphorylation were under the control of MEK , the upstream kinase of ERK . ^^^ ERK and MKP 2 stimulate the EBS / AP1 dependent transcriptional response to SF / HGF , but not JNK , which inhibits this response . ^^^ We further demonstrated that depending on cell density , the RAS ERK MKP 2 pathway controls this transrepressing effect of JNK . ^^^ Together , these data demonstrate that in a sequential manner SF / HGF activates ERK and MKP 2 , which in turn dephosphorylates JNK . ^^^ |
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| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13115 and P45983 |
Pubmed |
SVM Score :0.0 |
| NA |
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