| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Moreover , Caf 1 was associated with cyclin dependent kinases . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Conversely , CAF 1 recruitment is reduced in a PCNA / DNA loading assay using Cdc 7 depleted extracts . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Replication dependent marking of DNA by PCNA facilitates CAF 1 coupled inheritance of chromatin . ^^^ PCNA binds directly to p 150 , the largest subunit of CAF 1 , and the two proteins colocalize at sites of DNA replication in cells . ^^^ We suggest that PCNA and CAF 1 connect DNA replication to chromatin assembly and the inheritance of epigenetic chromosome states . . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| A CAF 1 PCNA mediated chromatin assembly pathway triggered by sensing DNA damage . ^^^ The binding of both PCNA and CAF 1 to this damaged DNA was dependent on the number of DNA lesions and required ATP . ^^^ We discuss the importance of the PCNA CAF 1 interaction in the context of DNA damage processing and checkpoint control . . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Inhibitor studies and add back experiments indicated requirements of cyclin A / Cdk2 , cyclin E / Cdk2 , and protein phosphatase type 1 ( PP 1 ) activities for nucleosome assembly during DNA synthesis by chromatin assembly factor 1 ( CAF 1 ) . ^^^ The p 60 subunit of CAF 1 is a molecular target for reversible phosphorylation by cyclin / Cdk complexes and PP 1 during nucleosome assembly and DNA synthesis in vitro . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Consistent with these phenotypes , mutant CAF 1 complexes defective for PCNA binding displayed reduced nucleosome assembly activity in vitro but were stimulated by Asf1p histone complexes . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Regulation of PCNA and CAF 1 expression by the two tuberous sclerosis gene products . ^^^ We found expression of PCNA and the p 48 subunit of CAF 1 to be regulated by two tuberous sclerosis gene products . ^^^ CAF 1 and PCNA interact as major regulators of chromatin assembly during DNA repair . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Use of nucleotide excision repair ( NER ) deficient cells shows that the NER pathway specifically dual incision is required for recruitment of CAF 1 and PCNA . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| We find that replication occurs mainly at the surface of these domains where both PCNA and chromatin assembly factor 1 ( CAF 1 ) are located . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| CAF 1 mediated resistance to DNA damage is dependent on the ability of CAF 1 to bind PCNA , indicating that PCNA may recruit CAF 1 to sites of double strand DNA repair . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Here we investigate the role of chromatin assembly factor 1 ( CAF 1 ) and its interacting protein , PCNA , in the response of quiescent human cells to DNA double strand breaks ( DSBs ) . ^^^ The expression of CAF 1 and PCNA is dramatically induced in quiescent cells upon the generation of DSBs by the radiomimetic drug bleocin ( a bleomycin compound ) or by ionizing radiation . ^^^ CAF 1 and PCNA are recruited to damaged chromatin undergoing DNA repair of single and double strand DNA breaks by the base excision repair and nonhomologous end joining pathways , respectively , in the absence of extensive DNA synthesis . ^^^ |
|
| Interacting proteins: Q13112 and P12004 |
Pubmed |
SVM Score :0.0 |
| Here , we provide evidence that a pool of p 21 protein is rapidly recruited to UV induced DNA damage sites , where it colocalises with PCNA and PCNA interacting proteins involved in nucleotide excision repair ( NER ) , such as DNA polymerase delta , XPG and CAF 1 . ^^^ |
|