| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| All transfectants showed a reduced sensitivity to tumor necrosis factor ( TNF ) induced apoptosis , which correlated with the amount of transgene expressed and with an enhanced basal transcription rate of NF kappaB driven genes including the inhibitor of apoptosis protein 2 ( cIAP 2 ) and TNF receptor associated protein 1 ( TRAF 1 ) . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NF kappaB antiapoptosis : induction of TRAF 1 and TRAF 2 and c IAP 1 and c IAP 2 to suppress caspase 8 activation . ^^^ TRAF 1 ( TNFR associated factor 1 ) , TRAF 2 , and the inhibitor of apoptosis ( IAP ) proteins c IAP 1 and c IAP 2 were identified as gene targets of NF kappaB transcriptional activity . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In normal tissue , expression of the known NF kappaB regulated antiapoptotic factors , TRAF 1 , TRAF 2 , c IAP 1 , and c IAP 2 , is most pronounced in outer epidermis . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Although c IAP 1 bound TRAF 2 and TRAF 1 in vitro , it ubiquitinated only TRAF 2 . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A RNase protection analysis showed that PMA stimulated the expression of several known anti apoptotic genes ( TRAF 1 , TRAF 4 , c IAP 1 , c IAP 2 , Bfl 1 , Bcl xl ) . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Cellular inhibitor of apoptosis protein 1 ( c IAP 1 ) can regulate apoptosis through its interaction with downstream TNF receptor effectors ( TRAF 1 and TRAF 2 ) , by binding to and inhibiting certain caspases , and by controlling the levels of specific proapoptotic stimuli ( e . g . , Smac / DIABLO ) within the cell . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| RESULTS : Multiple survival factor genes , including cellular inhibitor of apoptosis protein ( c IAP 1 ) , c IAP 2 , TNF receptor associated factor 1 ( TRAF 1 ) , TRAF 2 , B cell leukemia / lymphoma 2 ( Bcl 2 ) , Bcl 10 , A 1 , and cellular Fas associated death domain ( FADD ) like interleukin 1beta converting enzyme like inhibitory protein ( c FLIP ) , were expressed in basal conditions in both cultured RPE cells and RPE cells in situ , whereas survivin was expressed only by cultured cells . ^^^ TNF alpha upregulated expression of TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 . ^^^ TRAF 1 , c FLIP , and to a lesser extent c IAP 2 protein levels were increased by TNF alpha in a time dependent manner , whereas c IAP 1 , survivin , Bcl 10 ( L ) , and TRAF 2 protein levels were not influenced by TNF alpha treatment at any time point tested . ^^^ Overexpression of mutant IkappaB blocked TNF alpha induced TRAF 1 , TRAF 2 , c IAP 1 , c IAP 2 , c FLIP , and A 1 gene expression and downregulated TRAF 1 protein levels . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Activated TRAF 1 ( / ) T cells , but not TRAF 1 ( + / + ) T cells , responded to TNF by proliferation and activation of the NF kappa B and AP 1 signaling pathways . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| We have previously reported that tumor necrosis factor receptor associated factor 1 ( TRAF 1 ) , an intracellular protein , which binds to a range of molecules , including tumor necrosis factor ( TNF ) receptor family members , regulates TNF induced NF kappaB and AP 1 signaling as well as TCR triggered proliferative responses in T cells . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| RIP 2 interacted with other members of the TNFR 1 signaling complex , including inhibitor of apoptosis protein cIAP 1 and with members of the TNFR associated factor ( TRAF ) family , specifically TRAF 1 , TRAF 5 , and TRAF 6 , but not with TRAF 2 , TRAF 3 , or TRAF 4 . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Tumor necrosis factor ( TNF ) receptor ( TNFR ) associated factors 1 and 2 ( TRAF 1 and TRAF 2 ) and inhibitor of apoptosis proteins cIAP 1 ( MIHB ) and cIAP 2 ( MIHC ) were recently identified as proteins that associate with the TNF alpha receptors TNFRI ( p 55 ) and TNFRII ( p 75 ) and inhibit TNF alpha induced programmed cell death or apoptosis . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| Alteration of the transcription of anti apoptotic proteins , including inhibitor of apoptosis protein 1 , 2 ( cIAP 1 , 2 ) , TNF receptor associated factor 1 ( TRAF 1 ) , nuclear factor kappa B 1 protein ( NFkappaB 1 ) , and FLICE inhibitory protein ( FLIP ) was assessed by real time reverse transcriptase polymerase chain reaction ( RT PCR ) . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| A diminished induction of NF kappaB dependent target genes conveying either anti apoptotic or pro inflammatory functions , such as cIAP 1 , TRAF 1 , IL 6 , or IL 8 is observed . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| In the normal rat cortex , a portion of TNFR 1 was present in lipid raft microdomains , where it associated with the adaptor proteins TRADD ( TNF receptor associated death domain ) , TNF receptor associated factor 2 ( TRAF 2 ) , the Ser / Thr kinase RIP ( receptor interacting protein ) , TRAF 1 , and cIAP 1 ( cellular inhibitor of apoptosis protein 1 ) , forming a survival signaling complex . ^^^ |
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| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| As MIHB and MIHC were able to bind to the tumor necrosis factor receptor associated factors TRAF 1 and TRAF 2 in yeast two hybrid assays , these results suggest that IAP proteins that inhibit apoptosis may do so by regulating signals required for activation of ICE like proteases . . ^^^ |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|
| Interacting proteins: Q13490 and Q13077 |
Pubmed |
SVM Score :0.0 |
| NA |
|